S2546_CHICK
ID S2546_CHICK Reviewed; 408 AA.
AC Q5ZIG3;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Mitochondrial outer membrane protein SLC25A46 {ECO:0000250|UniProtKB:Q96AG3};
DE AltName: Full=Solute carrier family 25 member 46 {ECO:0000250|UniProtKB:Q96AG3};
GN Name=SLC25A46 {ECO:0000250|UniProtKB:Q96AG3};
GN ORFNames=RCJMB04_26i24 {ECO:0000312|EMBL:CAG32480.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Transmembrane protein of the mitochondrial outer membrane
CC that controls mitochondrial organization. May regulate the assembly of
CC the MICOS (mitochondrial contact site and cristae organizing system)
CC complex which is essential to the biogenesis and dynamics of
CC mitochondrial cristae, the inwards folds of the inner mitochondrial
CC membrane. Through its interaction with the EMC (endoplasmic reticulum
CC membrane protein complex), could regulate mitochondrial lipid
CC homeostasis and thereby mitochondrial fission.
CC {ECO:0000250|UniProtKB:Q96AG3}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q96AG3}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AJ720821; CAG32480.1; -; mRNA.
DR RefSeq; NP_001007831.1; NM_001007830.1.
DR AlphaFoldDB; Q5ZIG3; -.
DR STRING; 9031.ENSGALP00000000331; -.
DR PaxDb; Q5ZIG3; -.
DR Ensembl; ENSGALT00000000332; ENSGALP00000000331; ENSGALG00000000253.
DR GeneID; 415610; -.
DR KEGG; gga:415610; -.
DR CTD; 91137; -.
DR VEuPathDB; HostDB:geneid_415610; -.
DR eggNOG; KOG2954; Eukaryota.
DR GeneTree; ENSGT00390000015874; -.
DR HOGENOM; CLU_047010_0_0_1; -.
DR InParanoid; Q5ZIG3; -.
DR OMA; HKWNLKQ; -.
DR OrthoDB; 937901at2759; -.
DR PhylomeDB; Q5ZIG3; -.
DR TreeFam; TF313365; -.
DR PRO; PR:Q5ZIG3; -.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000000253; Expressed in spermatocyte and 12 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0061564; P:axon development; IBA:GO_Central.
DR GO; GO:0042407; P:cristae formation; IEA:Ensembl.
DR GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR GO; GO:0090149; P:mitochondrial membrane fission; IEA:InterPro.
DR GO; GO:0055091; P:phospholipid homeostasis; IEA:Ensembl.
DR GO; GO:0008535; P:respiratory chain complex IV assembly; IEA:Ensembl.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR039158; SLC25A46.
DR PANTHER; PTHR21252; PTHR21252; 1.
DR Pfam; PF00153; Mito_carr; 2.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..408
FT /note="Mitochondrial outer membrane protein SLC25A46"
FT /id="PRO_0000291831"
FT TRANSMEM 93..113
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 86..177
FT /note="Solcar 1"
FT REPEAT 301..403
FT /note="Solcar 2"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 408 AA; 44642 MW; 4A96EDF538111C8F CRC64;
MHPRRPEGFD GLGYRGGGRE EPCPGVRPFG GGAEMGHWVT TPPDIPGSRN LHWGEKTPPY
GAGTPLGAAG LNEEPGLGAG GPGAEQLNRF AGFGIGLASL FTENVLAHPC IVLRRQCQVN
YHARNYHLTP FTIVNIMYSI NKTQGPRALW KGMGSTFIVQ GITLGTEGII SEFTPLPREL
SHKWNLKQIG GHLLLKGLTH VIAMPFYSAS LIETVQSEII RDNPGILDCV KEGIGRVVGM
GVPHSKRLLP LMVLIFPTAL HGVLHYVISS IVQKLVLLFL KRENSHSLPT ESSTSVQSML
DAYFPELIAS FAASLCADVM LYPLETVLHR LHIQGTRTII DNTDLGYEVL PINTQYEGMR
DCINTIKREE GMLGFYKGFG AVVVQYTLHV AVLQLTKIIY STLLQNVS
