ID   S2546_XENTR             Reviewed;         416 AA.
AC   A4IIC3; Q28FB7;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Solute carrier family 25 member 46;
GN   Name=slc25a46; ORFNames=TEgg014d12.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in mitochondrial dynamics by controlling
CC       mitochondrial membrane fission. {ECO:0000250|UniProtKB:Q96AG3}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q96AG3}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAJ81828.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR762049; CAJ81828.1; ALT_INIT; mRNA.
DR   EMBL; BC135960; AAI35961.1; -; mRNA.
DR   RefSeq; NP_001016130.1; NM_001016130.2.
DR   AlphaFoldDB; A4IIC3; -.
DR   STRING; 8364.ENSXETP00000058845; -.
DR   PaxDb; A4IIC3; -.
DR   DNASU; 548884; -.
DR   GeneID; 548884; -.
DR   KEGG; xtr:548884; -.
DR   CTD; 91137; -.
DR   Xenbase; XB-GENE-5803974; slc25a46.
DR   eggNOG; KOG2954; Eukaryota.
DR   HOGENOM; CLU_047010_0_0_1; -.
DR   InParanoid; A4IIC3; -.
DR   OrthoDB; 937901at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0061564; P:axon development; IBA:GO_Central.
DR   GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090149; P:mitochondrial membrane fission; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR039158; SLC25A46.
DR   PANTHER; PTHR21252; PTHR21252; 1.
DR   Pfam; PF00153; Mito_carr; 2.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..416
FT                   /note="Solute carrier family 25 member 46"
FT                   /id="PRO_0000291835"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          94..185
FT                   /note="Solcar 1"
FT   REPEAT          309..414
FT                   /note="Solcar 2"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        59
FT                   /note="R -> C (in Ref. 1; CAJ81828)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   416 AA;  45834 MW;  9E8702CB03B36EAA CRC64;
     MQPRRPDRFD GLEYRGTSWG RGDGDVPPYQ HGFPARSFSS SGDLSQHWVT TPPDIPGSRN
     LHWGEKSPQY GADSNAGPAA VGEESSSSSS GGEHLNRFAG FGIGLASLFT ENVLAHPCIV
     LRRQCQVNYH ARNYQLSPFS IVNIMYSFTK TQGFRALWKG MGSTFIVQGI SLGAEGMLSE
     FTHLPRELNH KWNPKQIGGH LLLKGLVYVI VTPFYSASLI ETVQSEIIHD NPGILDCLKE
     GIGRVLNLGV PYSKRLLPLL VLTFPTVLHG ILHYIISSTI QKCVLFFIKK KSPAQLPGDG
     SNAVQNKLED YFPELIANFA ASLCADVLLY PLETVLHRLH IQGTRTIIDN TDLGHEVVPI
     NSQYEGLKDC INTIKREEGG LGFYKGFGAV VVQYTLHAIV LQITKIIYSS VVQTAS