S2547_MOUSE
ID S2547_MOUSE Reviewed; 310 AA.
AC Q6IS41; Q3UES2; Q5FW58; Q7TPP3;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Solute carrier family 25 member 47;
DE AltName: Full=Hepatocellular carcinoma down-regulated mitochondrial carrier homolog;
GN Name=Slc25a47; Synonyms=Hdmcp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Uncoupling protein which may catalyze the physiological
CC 'proton leak' in liver. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH55027.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK149369; BAE28839.1; -; mRNA.
DR EMBL; BC055027; AAH55027.1; ALT_INIT; mRNA.
DR EMBL; BC069939; AAH69939.2; -; mRNA.
DR EMBL; BC089616; AAH89616.1; -; mRNA.
DR CCDS; CCDS26165.1; -.
DR RefSeq; NP_001012310.2; NM_001012310.2.
DR AlphaFoldDB; Q6IS41; -.
DR SMR; Q6IS41; -.
DR STRING; 10090.ENSMUSP00000050329; -.
DR iPTMnet; Q6IS41; -.
DR PhosphoSitePlus; Q6IS41; -.
DR PaxDb; Q6IS41; -.
DR PRIDE; Q6IS41; -.
DR Antibodypedia; 27517; 93 antibodies from 23 providers.
DR DNASU; 104910; -.
DR Ensembl; ENSMUST00000057026; ENSMUSP00000050329; ENSMUSG00000048856.
DR GeneID; 104910; -.
DR KEGG; mmu:104910; -.
DR UCSC; uc007pae.1; mouse.
DR CTD; 283600; -.
DR MGI; MGI:2144766; Slc25a47.
DR VEuPathDB; HostDB:ENSMUSG00000048856; -.
DR eggNOG; KOG0762; Eukaryota.
DR GeneTree; ENSGT00940000159694; -.
DR HOGENOM; CLU_015166_16_1_1; -.
DR InParanoid; Q6IS41; -.
DR OMA; HICRLRY; -.
DR OrthoDB; 1072378at2759; -.
DR PhylomeDB; Q6IS41; -.
DR TreeFam; TF351739; -.
DR BioGRID-ORCS; 104910; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Slc25a47; mouse.
DR PRO; PR:Q6IS41; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q6IS41; protein.
DR Bgee; ENSMUSG00000048856; Expressed in left lobe of liver and 159 other tissues.
DR ExpressionAtlas; Q6IS41; baseline and differential.
DR Genevisible; Q6IS41; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..310
FT /note="Solute carrier family 25 member 47"
FT /id="PRO_0000291780"
FT TRANSMEM 3..23
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..210
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..298
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 1..80
FT /note="Solcar 1"
FT REPEAT 93..208
FT /note="Solcar 2"
FT REPEAT 217..304
FT /note="Solcar 3"
FT CONFLICT 182
FT /note="K -> M (in Ref. 2; AAH89616)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 33646 MW; F5571D9E0D9431F0 CRC64;
MDFVAGAIGG VCGVAVGYPL DTVKVRIQTE AKYAGIWHCI RDTYRQERVW GFYRGLSLPV
CTVSLVSSVS FGTYHHCLAH ICRFRYGSTD AKPTKADITL SGCASGLVRV FLTSPTEVAK
VRLQTQTQAQ TQQRRSSASW TSGAPALCPT PTACLEPRPK YSGPLHCLVT VAREEGLRGL
YKGSSALLLR EGHSFATYFL SYAMLCEWLT PAGHSQPDVL GVLVAGGCAG VLAWAVATPM
DVIKSRLQAD GQGQHRYRGL LHCVVTSVRE EGPRVLFKGL ALNCCRAFPV NMVVFVAYEA
VLRLTQSLLT
