ID   S2547_RAT               Reviewed;         310 AA.
AC   Q6J329;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Solute carrier family 25 member 47;
DE   AltName: Full=Hepatocellular carcinoma down-regulated mitochondrial carrier homolog;
GN   Name=Slc25a47; Synonyms=Hdmcp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RX   PubMed=15322095; DOI=10.1074/jbc.m403683200;
RA   Tan M.G.K., Ooi L.L.P.J., Aw S.E., Hui K.M.;
RT   "Cloning and identification of hepatocellular carcinoma down-regulated
RT   mitochondrial carrier protein, a novel liver-specific uncoupling protein.";
RL   J. Biol. Chem. 279:45235-45244(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Uncoupling protein which may catalyze the physiological
CC       'proton leak' in liver. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AY603424; AAT35561.1; -; mRNA.
DR   EMBL; BC089874; AAH89874.1; -; mRNA.
DR   RefSeq; NP_001001509.1; NM_001001509.1.
DR   AlphaFoldDB; Q6J329; -.
DR   SMR; Q6J329; -.
DR   STRING; 10116.ENSRNOP00000004070; -.
DR   PaxDb; Q6J329; -.
DR   Ensembl; ENSRNOT00000004070; ENSRNOP00000004070; ENSRNOG00000003020.
DR   GeneID; 299316; -.
DR   KEGG; rno:299316; -.
DR   UCSC; RGD:1303247; rat.
DR   CTD; 283600; -.
DR   RGD; 1303247; Slc25a47.
DR   eggNOG; KOG0762; Eukaryota.
DR   GeneTree; ENSGT00940000159694; -.
DR   HOGENOM; CLU_015166_16_1_1; -.
DR   InParanoid; Q6J329; -.
DR   OMA; HICRLRY; -.
DR   OrthoDB; 1072378at2759; -.
DR   PhylomeDB; Q6J329; -.
DR   TreeFam; TF351739; -.
DR   PRO; PR:Q6J329; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000003020; Expressed in liver and 2 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..310
FT                   /note="Solute carrier family 25 member 47"
FT                   /id="PRO_0000291781"
FT   TRANSMEM        3..23
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..116
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1..80
FT                   /note="Solcar 1"
FT   REPEAT          93..208
FT                   /note="Solcar 2"
FT   REPEAT          217..304
FT                   /note="Solcar 3"
SQ   SEQUENCE   310 AA;  33618 MW;  9CFB1B6DC9B5C93A CRC64;
     MDFVAGAIGG VCGVAVGYPL DTVKVKIQTE AKYTSIWHCV RDTYRQERLW GFYRGLSLPV
     CTVSLVSSVS FGTYHHCLAH ICRFRYGSTD VKPTKADITL SGCASGLVRV FLTSPTEVAK
     VRLQTQAQSQ TQQRRPSASW TSVAPALCPA PTACLEPRPK YSGPLHCLVT VAREEGLRGL
     YKGSSALLLR EGHSFATYFL SYAVLSEWLT PAGQSQPDVL GVLVAGGCAG VLAWAVATPM
     DVIKSRLQAD GQGQQRYRGL LHCVVTSVRE EGPRVLFKGL ALNCCRAFPV NMVVFVAYEA
     VLRLTQGLLT