S2548_MOUSE
ID S2548_MOUSE Reviewed; 306 AA.
AC Q8BW66; Q3KNJ4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Solute carrier family 25 member 48;
GN Name=Slc25a48;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Oviduct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK054181; BAC35684.1; -; mRNA.
DR EMBL; BC107250; AAI07251.1; -; mRNA.
DR EMBL; BC107251; AAI07252.1; -; mRNA.
DR CCDS; CCDS26561.1; -.
DR RefSeq; NP_808477.2; NM_177809.4.
DR RefSeq; XP_006517341.1; XM_006517278.3.
DR RefSeq; XP_011242834.1; XM_011244532.1.
DR AlphaFoldDB; Q8BW66; -.
DR SMR; Q8BW66; -.
DR STRING; 10090.ENSMUSP00000021971; -.
DR iPTMnet; Q8BW66; -.
DR PhosphoSitePlus; Q8BW66; -.
DR jPOST; Q8BW66; -.
DR PaxDb; Q8BW66; -.
DR PeptideAtlas; Q8BW66; -.
DR PRIDE; Q8BW66; -.
DR ProteomicsDB; 260768; -.
DR Antibodypedia; 7244; 39 antibodies from 12 providers.
DR DNASU; 328258; -.
DR Ensembl; ENSMUST00000021971; ENSMUSP00000021971; ENSMUSG00000021509.
DR GeneID; 328258; -.
DR KEGG; mmu:328258; -.
DR UCSC; uc007qsn.2; mouse.
DR CTD; 153328; -.
DR MGI; MGI:2145373; Slc25a48.
DR VEuPathDB; HostDB:ENSMUSG00000021509; -.
DR eggNOG; KOG0752; Eukaryota.
DR eggNOG; KOG0758; Eukaryota.
DR GeneTree; ENSGT00940000159354; -.
DR HOGENOM; CLU_015166_16_1_1; -.
DR InParanoid; Q8BW66; -.
DR OMA; YGVWFLA; -.
DR OrthoDB; 1072378at2759; -.
DR PhylomeDB; Q8BW66; -.
DR TreeFam; TF351739; -.
DR BioGRID-ORCS; 328258; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Slc25a48; mouse.
DR PRO; PR:Q8BW66; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8BW66; protein.
DR Bgee; ENSMUSG00000021509; Expressed in animal zygote and 53 other tissues.
DR Genevisible; Q8BW66; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..306
FT /note="Solute carrier family 25 member 48"
FT /id="PRO_0000325769"
FT TRANSMEM 9..29
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 3..86
FT /note="Solcar 1"
FT REPEAT 101..200
FT /note="Solcar 2"
FT REPEAT 209..296
FT /note="Solcar 3"
FT CONFLICT 177
FT /note="S -> N (in Ref. 1; BAC35684)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 306 AA; 33387 MW; D55975DE6C864826 CRC64;
MGSFQLEDFV AGWIGGVASV IVGYPLDTVK TRLQAGVGYA NTFNCIRMVY KRERVFGFFK
GMSFPLASIA IYNSVVFGVF SNTQRFLSKY RCGELEAGPG RSLSDLLLAS MLTGVVSVGL
GGPVELIKIR LQMQTQPFRE ASHGLKSRAV AAYQGPVHCI ATIVQMEGLT GLYRGASAML
LRDIPGYCFY FIPYVFLSEW ITPEACTGPS PYAAWLAGGI AGAISWGTAT PMDVVKSRIQ
ADGVYLNKYR GVVDCISQSY QQEGFKVFFR GITVNAVRGF PMSAAMFLGY ELSLKALRGE
HTVRSE
