S2551_MOUSE
ID S2551_MOUSE Reviewed; 298 AA.
AC Q5HZI9; Q3U190; Q3UCW5;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 {ECO:0000305};
DE AltName: Full=Mitochondrial NAD(+) transporter SLC25A51 {ECO:0000305};
DE AltName: Full=Mitochondrial carrier triple repeat protein 1 {ECO:0000305};
DE AltName: Full=Solute carrier family 25 member 51 {ECO:0000305};
GN Name=Slc25a51 {ECO:0000312|MGI:MGI:2684984};
GN Synonyms=Mcart1 {ECO:0000312|MGI:MGI:2684984};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Kidney, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Mitochondrial membrane carrier protein that mediates the
CC import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required
CC for glycolysis and mitochondrial respiration. Compared to SLC25A52,
CC SLC25A51-mediated transport is essential for the import of NAD(+) in
CC mitochondria. {ECO:0000250|UniProtKB:Q9H1U9}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9H1U9}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE27432.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE29497.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE30612.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE31003.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE33610.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE38106.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK146788; BAE27432.1; ALT_INIT; mRNA.
DR EMBL; AK150362; BAE29497.1; ALT_INIT; mRNA.
DR EMBL; AK151688; BAE30612.1; ALT_INIT; mRNA.
DR EMBL; AK152171; BAE31003.1; ALT_INIT; mRNA.
DR EMBL; AK156168; BAE33610.1; ALT_INIT; mRNA.
DR EMBL; AK165253; BAE38106.1; ALT_INIT; mRNA.
DR EMBL; BC089000; AAH89000.1; -; mRNA.
DR CCDS; CCDS18137.1; -.
DR RefSeq; NP_001009949.3; NM_001009949.3.
DR RefSeq; XP_006537898.1; XM_006537835.3.
DR RefSeq; XP_017175615.1; XM_017320126.1.
DR AlphaFoldDB; Q5HZI9; -.
DR SMR; Q5HZI9; -.
DR IntAct; Q5HZI9; 1.
DR MINT; Q5HZI9; -.
DR STRING; 10090.ENSMUSP00000103425; -.
DR iPTMnet; Q5HZI9; -.
DR PhosphoSitePlus; Q5HZI9; -.
DR SwissPalm; Q5HZI9; -.
DR EPD; Q5HZI9; -.
DR jPOST; Q5HZI9; -.
DR MaxQB; Q5HZI9; -.
DR PaxDb; Q5HZI9; -.
DR PeptideAtlas; Q5HZI9; -.
DR PRIDE; Q5HZI9; -.
DR ProteomicsDB; 256671; -.
DR DNASU; 230125; -.
DR Ensembl; ENSMUST00000116341; ENSMUSP00000112044; ENSMUSG00000045973.
DR Ensembl; ENSMUST00000132815; ENSMUSP00000134132; ENSMUSG00000045973.
DR GeneID; 230125; -.
DR KEGG; mmu:230125; -.
DR UCSC; uc008ssr.2; mouse.
DR CTD; 92014; -.
DR MGI; MGI:2684984; Slc25a51.
DR VEuPathDB; HostDB:ENSMUSG00000045973; -.
DR eggNOG; KOG1519; Eukaryota.
DR GeneTree; ENSGT00940000155622; -.
DR HOGENOM; CLU_061821_0_0_1; -.
DR InParanoid; Q5HZI9; -.
DR OMA; GCAFNTG; -.
DR OrthoDB; 966424at2759; -.
DR BioGRID-ORCS; 230125; 20 hits in 73 CRISPR screens.
DR ChiTaRS; Slc25a51; mouse.
DR PRO; PR:Q5HZI9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q5HZI9; protein.
DR Bgee; ENSMUSG00000045973; Expressed in fetal liver hematopoietic progenitor cell and 257 other tissues.
DR ExpressionAtlas; Q5HZI9; baseline and differential.
DR Genevisible; Q5HZI9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0051724; F:NAD transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0019646; P:aerobic electron transport chain; ISS:UniProtKB.
DR GO; GO:1990549; P:mitochondrial NAD transmembrane transport; ISS:UniProtKB.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..298
FT /note="Mitochondrial nicotinamide adenine dinucleotide
FT transporter SLC25A51"
FT /id="PRO_0000090712"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 28..108
FT /note="Solcar 1"
FT /evidence="ECO:0000255"
FT REPEAT 117..201
FT /note="Solcar 2"
FT /evidence="ECO:0000255"
FT REPEAT 214..297
FT /note="Solcar 3"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 294..298
FT /note="LLKIV -> FVKDCMMKSLCEMLFSSN (in Ref. 1; BAE33610)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 298 AA; 33689 MW; 28DF1E7411847065 CRC64;
MMDSEAHEKR PPMLTSSNQD LSPHIAGVGD MKHYLCGYCA AFNNVAITYP VQKILFRQQL
YGIKTRDAVL QLRKDGFRNL YRGILPPLMQ KTTTLALMFG LYEDLSRLLH KHVSSAPEFA
TRSVAALLAG TTEAILTPFE RVQTLLQDHK HHDKFTNTYQ AFRALRCHGI AEYYRGMVPI
LFRNGFGNVL FFGLRGPIKE SLPTATTYSA HLVNDFICGG VLGAVLGFLS FPINVVKARI
QSQIGGPFLS LPMVFKTIWI ERDRKLINLF RGAHLNYHRS LISWGIINAT YEFLLKIV
