ID   S2551_RAT               Reviewed;         298 AA.
AC   Q52KK3;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 {ECO:0000305};
DE   AltName: Full=Mitochondrial NAD(+) transporter SLC25A51 {ECO:0000305};
DE   AltName: Full=Mitochondrial carrier triple repeat protein 1 {ECO:0000305};
DE   AltName: Full=Solute carrier family 25 member 51 {ECO:0000305};
GN   Name=Slc25a51 {ECO:0000312|RGD:1305190};
GN   Synonyms=Mcart1 {ECO:0000312|RGD:1305190};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Mitochondrial membrane carrier protein that mediates the
CC       import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required
CC       for glycolysis and mitochondrial respiration. Compared to SLC25A52,
CC       SLC25A51-mediated transport is essential for the import of NAD(+) in
CC       mitochondria. {ECO:0000250|UniProtKB:Q9H1U9}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9H1U9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC094303; AAH94303.1; -; mRNA.
DR   EMBL; BC094527; AAH94527.1; -; mRNA.
DR   RefSeq; NP_001019956.1; NM_001024785.2.
DR   RefSeq; XP_003749980.1; XM_003749932.4.
DR   RefSeq; XP_006238126.1; XM_006238064.2.
DR   RefSeq; XP_006238127.1; XM_006238065.3.
DR   RefSeq; XP_006238211.1; XM_006238149.3.
DR   AlphaFoldDB; Q52KK3; -.
DR   SMR; Q52KK3; -.
DR   IntAct; Q52KK3; 2.
DR   STRING; 10116.ENSRNOP00000056892; -.
DR   jPOST; Q52KK3; -.
DR   PaxDb; Q52KK3; -.
DR   PRIDE; Q52KK3; -.
DR   Ensembl; ENSRNOT00000060149; ENSRNOP00000056892; ENSRNOG00000039278.
DR   Ensembl; ENSRNOT00000071116; ENSRNOP00000065025; ENSRNOG00000039278.
DR   Ensembl; ENSRNOT00000120005; ENSRNOP00000077579; ENSRNOG00000039278.
DR   GeneID; 313241; -.
DR   KEGG; rno:313241; -.
DR   UCSC; RGD:1305190; rat.
DR   CTD; 92014; -.
DR   RGD; 1305190; Mcart1.
DR   VEuPathDB; HostDB:ENSRNOG00000070747; -.
DR   eggNOG; KOG1519; Eukaryota.
DR   GeneTree; ENSGT00940000155622; -.
DR   HOGENOM; CLU_061821_0_0_1; -.
DR   InParanoid; Q52KK3; -.
DR   OMA; GCAFNTG; -.
DR   OrthoDB; 966424at2759; -.
DR   PhylomeDB; Q52KK3; -.
DR   TreeFam; TF314192; -.
DR   PRO; PR:Q52KK3; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000039278; Expressed in Ammon's horn and 19 other tissues.
DR   Genevisible; Q52KK3; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0051724; F:NAD transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0019646; P:aerobic electron transport chain; ISS:UniProtKB.
DR   GO; GO:1990549; P:mitochondrial NAD transmembrane transport; ISS:UniProtKB.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..298
FT                   /note="Mitochondrial nicotinamide adenine dinucleotide
FT                   transporter SLC25A51"
FT                   /id="PRO_0000271789"
FT   TRANSMEM        34..51
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..290
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          28..108
FT                   /note="Solcar 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          117..201
FT                   /note="Solcar 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          214..297
FT                   /note="Solcar 3"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   298 AA;  33774 MW;  1DE6B15948D9A197 CRC64;
     MMGSEAHDKR PPMLTSSNQD LSPHLADVGQ IKHYFCGCCA AFNNVAITYP VQKILFRQQL
     YGIKTRDAIL QLRKDGFRNL YRGILPPLMQ KTTTLALMFG LYEDLSRLLR KHVSNAPEFA
     TRSVAALLAG TTEAILTPLE RVQTLLQDHK HHDKFTNTYQ AFRALRCHGV AEYYRGLVPI
     LFRNGFSNIL FFGLRGPIKE HLPTATTNSE HLVNDFICGG VLGAMLGFLS FPVNVVKARI
     QSQIGGPFQS LPMVFKTIWI ERDRKLINLF RGAHLNYHRS LISWGIINAT YEFLLKIV