S2552_HUMAN
ID S2552_HUMAN Reviewed; 297 AA.
AC Q3SY17;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A52 {ECO:0000305};
DE AltName: Full=Mitochondrial NAD(+) transporter SLC25A52 {ECO:0000305};
DE AltName: Full=Mitochondrial carrier triple repeat protein 2 {ECO:0000305};
DE AltName: Full=Solute carrier family 25 member 52 {ECO:0000303|PubMed:32906142};
GN Name=SLC25A52 {ECO:0000303|PubMed:32906142, ECO:0000312|HGNC:HGNC:23324};
GN Synonyms=MCART2 {ECO:0000312|HGNC:HGNC:23324};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-239.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, TRANSPORTER ACTIVITY, AND SUBCELLULAR LOCATION.
RX PubMed=32906142; DOI=10.1038/s41586-020-2741-7;
RA Luongo T.S., Eller J.M., Lu M.J., Niere M., Raith F., Perry C.,
RA Bornstein M.R., Oliphint P., Wang L., McReynolds M.R., Migaud M.E.,
RA Rabinowitz J.D., Johnson F.B., Johnsson K., Ziegler M., Cambronne X.A.,
RA Baur J.A.;
RT "SLC25A51 is a mammalian mitochondrial NAD+ transporter.";
RL Nature 588:174-179(2020).
CC -!- FUNCTION: Mitochondrial membrane carrier protein that mediates the
CC import of NAD(+) into mitochondria (PubMed:32906142). Compared to
CC SLC25A51, SLC25A52-mediated transport is not essential for the import
CC of NAD(+) in mitochondria (PubMed:32906142).
CC {ECO:0000269|PubMed:32906142}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:32906142}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AC022960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC103999; AAI04000.1; -; mRNA.
DR EMBL; BC104000; AAI04001.1; -; mRNA.
DR EMBL; BC104001; AAI04002.1; -; mRNA.
DR CCDS; CCDS32812.2; -.
DR RefSeq; NP_001029344.3; NM_001034172.2.
DR AlphaFoldDB; Q3SY17; -.
DR SMR; Q3SY17; -.
DR BioGRID; 127058; 9.
DR IntAct; Q3SY17; 2.
DR STRING; 9606.ENSP00000372612; -.
DR TCDB; 2.A.29.2.12; the mitochondrial carrier (mc) family.
DR iPTMnet; Q3SY17; -.
DR PhosphoSitePlus; Q3SY17; -.
DR BioMuta; SLC25A52; -.
DR DMDM; 296436436; -.
DR EPD; Q3SY17; -.
DR jPOST; Q3SY17; -.
DR MassIVE; Q3SY17; -.
DR MaxQB; Q3SY17; -.
DR PaxDb; Q3SY17; -.
DR PeptideAtlas; Q3SY17; -.
DR PRIDE; Q3SY17; -.
DR ProteomicsDB; 61835; -.
DR Antibodypedia; 54450; 85 antibodies from 16 providers.
DR DNASU; 147407; -.
DR Ensembl; ENST00000269205.7; ENSP00000372612.4; ENSG00000141437.10.
DR GeneID; 147407; -.
DR KEGG; hsa:147407; -.
DR MANE-Select; ENST00000269205.7; ENSP00000372612.4; NM_001034172.4; NP_001029344.4.
DR CTD; 147407; -.
DR DisGeNET; 147407; -.
DR GeneCards; SLC25A52; -.
DR HGNC; HGNC:23324; SLC25A52.
DR HPA; ENSG00000141437; Tissue enriched (testis).
DR MIM; 616153; gene.
DR neXtProt; NX_Q3SY17; -.
DR OpenTargets; ENSG00000141437; -.
DR PharmGKB; PA25306; -.
DR VEuPathDB; HostDB:ENSG00000141437; -.
DR eggNOG; KOG1519; Eukaryota.
DR GeneTree; ENSGT00940000155622; -.
DR InParanoid; Q3SY17; -.
DR OrthoDB; 966424at2759; -.
DR PhylomeDB; Q3SY17; -.
DR TreeFam; TF314192; -.
DR PathwayCommons; Q3SY17; -.
DR SignaLink; Q3SY17; -.
DR BioGRID-ORCS; 147407; 6 hits in 1008 CRISPR screens.
DR GenomeRNAi; 147407; -.
DR Pharos; Q3SY17; Tdark.
DR PRO; PR:Q3SY17; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q3SY17; protein.
DR Bgee; ENSG00000141437; Expressed in testis and 46 other tissues.
DR ExpressionAtlas; Q3SY17; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0051724; F:NAD transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:1990549; P:mitochondrial NAD transmembrane transport; IDA:UniProtKB.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..297
FT /note="Mitochondrial nicotinamide adenine dinucleotide
FT transporter SLC25A52"
FT /id="PRO_0000271790"
FT TRANSMEM 34..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 28..108
FT /note="Solcar 1"
FT /evidence="ECO:0000255"
FT REPEAT 116..200
FT /note="Solcar 2"
FT /evidence="ECO:0000255"
FT REPEAT 209..296
FT /note="Solcar 3"
FT /evidence="ECO:0000255"
FT VARIANT 239
FT /note="L -> I (in dbSNP:rs3859364)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060299"
SQ SEQUENCE 297 AA; 33721 MW; 8BA8EFEABA74E2FC CRC64;
MIDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITYP IQKVLFRQQL
YGIKTRDAVL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG LYEDLSCLLR KHVRAPEFAT
HGVAAVLAGT AEAIFTPLER VQTLLQNHKH HDKFTNTYQA FKALKCHGIG EYYRGLVPIL
FRNGLSNVLF FGLRGPIKEH LPTATTHSAH LVNDFIGGGL LGAMLGFLCF PINVVKTRLQ
SQIGGEFQSF PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKFI
