S2553_HUMAN
ID S2553_HUMAN Reviewed; 307 AA.
AC Q5H9E4; B2RTT9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Solute carrier family 25 member 53;
DE AltName: Full=Mitochondrial carrier triple repeat protein 6;
GN Name=SLC25A53; Synonyms=MCART6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; Z82254; CAI41997.1; -; Genomic_DNA.
DR EMBL; CH471120; EAX02763.1; -; Genomic_DNA.
DR EMBL; BC140812; AAI40813.1; -; mRNA.
DR EMBL; BC140814; AAI40815.1; -; mRNA.
DR CCDS; CCDS35363.1; -.
DR RefSeq; NP_001012773.2; NM_001012755.4.
DR RefSeq; XP_005262186.1; XM_005262129.4.
DR RefSeq; XP_011529254.1; XM_011530952.2.
DR RefSeq; XP_011529255.1; XM_011530953.2.
DR RefSeq; XP_016885005.1; XM_017029516.1.
DR AlphaFoldDB; Q5H9E4; -.
DR SMR; Q5H9E4; -.
DR BioGRID; 135171; 1.
DR IntAct; Q5H9E4; 1.
DR STRING; 9606.ENSP00000468980; -.
DR BioMuta; SLC25A53; -.
DR DMDM; 74755435; -.
DR MassIVE; Q5H9E4; -.
DR PaxDb; Q5H9E4; -.
DR PeptideAtlas; Q5H9E4; -.
DR PRIDE; Q5H9E4; -.
DR ProteomicsDB; 62885; -.
DR Antibodypedia; 73245; 81 antibodies from 16 providers.
DR DNASU; 401612; -.
DR Ensembl; ENST00000594199.3; ENSP00000468980.1; ENSG00000269743.3.
DR GeneID; 401612; -.
DR KEGG; hsa:401612; -.
DR MANE-Select; ENST00000594199.3; ENSP00000468980.1; NM_001012755.5; NP_001012773.2.
DR UCSC; uc022cbz.2; human.
DR CTD; 401612; -.
DR GeneCards; SLC25A53; -.
DR HGNC; HGNC:31894; SLC25A53.
DR HPA; ENSG00000269743; Tissue enhanced (lymphoid).
DR MIM; 300941; gene.
DR neXtProt; NX_Q5H9E4; -.
DR OpenTargets; ENSG00000269743; -.
DR PharmGKB; PA142671476; -.
DR VEuPathDB; HostDB:ENSG00000269743; -.
DR eggNOG; KOG1519; Eukaryota.
DR GeneTree; ENSGT00940000161713; -.
DR HOGENOM; CLU_061821_1_0_1; -.
DR InParanoid; Q5H9E4; -.
DR OMA; WPVLLRN; -.
DR OrthoDB; 1309864at2759; -.
DR PhylomeDB; Q5H9E4; -.
DR TreeFam; TF314192; -.
DR PathwayCommons; Q5H9E4; -.
DR SignaLink; Q5H9E4; -.
DR BioGRID-ORCS; 401612; 14 hits in 661 CRISPR screens.
DR ChiTaRS; SLC25A53; human.
DR GenomeRNAi; 401612; -.
DR Pharos; Q5H9E4; Tdark.
DR PRO; PR:Q5H9E4; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5H9E4; protein.
DR Bgee; ENSG00000269743; Expressed in calcaneal tendon and 96 other tissues.
DR Genevisible; Q5H9E4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0051724; F:NAD transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 2.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..307
FT /note="Solute carrier family 25 member 53"
FT /id="PRO_0000271791"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 25..105
FT /note="Solcar 1"
FT REPEAT 112..202
FT /note="Solcar 2"
FT REPEAT 210..302
FT /note="Solcar 3"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 34481 MW; 830E366B62DC87AD CRC64;
MGEQNHSPGK ELQHRTRAEA PGKKSWHSQA YALGAVSNFM STFLTFPIYK VVFRQQIHAM
AVSEAVRQLW HEGPQYFYRG IYPPLLSKTL QGTLLFGTYD SLLCFLSPVG PHTLGHRWAA
GLMSGVVEAV ALSPFERVQN VLQDGRKQAR FPSTFSILKE FNSYGLWGRL SLGYYRGFWP
VLARNSLGSA LYFSFKDPIQ DGLAEQGLPH WVPALVSGSV NGTITCLVLY PLIVLVANMQ
SHIGWQNMPS LWASAQDVWN TRGRKLLLIY RGGSLVILRS SVTWGLTTAI HDFLQRKSHS
RKELKTD
