S2610_HUMAN
ID S2610_HUMAN Reviewed; 563 AA.
AC Q8NG04; A6NMJ2; B6ZDQ3; Q6ZWI7;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Solute carrier family 26 member 10;
GN Name=SLC26A10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11087667; DOI=10.1006/geno.2000.6355;
RA Lohi H., Kujala M., Kerkelae E., Saarialho-Kere U., Kestilae M., Kere J.;
RT "Mapping of five new putative anion transporter genes in human and
RT characterization of SLC26A6, a candidate gene for pancreatic anion
RT exchanger.";
RL Genomics 70:102-112(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-563 (ISOFORM 2), AND VARIANT
RP THR-193.
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=12759755; DOI=10.1007/s00424-003-1090-3;
RA Mount D.B., Romero M.F.;
RT "The SLC26 gene family of multifunctional anion exchangers.";
RL Pflugers Arch. 447:710-721(2004).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] SER-270.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Chloride/bicarbonate exchanger. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NG04-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NG04-2; Sequence=VSP_034748, VSP_034749;
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
CC -!- CAUTION: According to PubMed:12759755, it is a transcribed pseudogene.
CC They however do not provide experimental evidences to support this
CC affirmation. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC85515.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF331523; AAM92901.1; -; mRNA.
DR EMBL; AC025165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK122981; BAC85515.1; ALT_INIT; mRNA.
DR RefSeq; NP_597996.2; NM_133489.2.
DR AlphaFoldDB; Q8NG04; -.
DR SMR; Q8NG04; -.
DR BioGRID; 122374; 1.
DR STRING; 9606.ENSP00000320217; -.
DR TCDB; 2.A.53.2.13; the sulfate permease (sulp) family.
DR iPTMnet; Q8NG04; -.
DR PhosphoSitePlus; Q8NG04; -.
DR BioMuta; SLC26A10; -.
DR DMDM; 74715621; -.
DR EPD; Q8NG04; -.
DR PaxDb; Q8NG04; -.
DR PeptideAtlas; Q8NG04; -.
DR PRIDE; Q8NG04; -.
DR ProteomicsDB; 73403; -. [Q8NG04-2]
DR DNASU; 65012; -.
DR GeneID; 65012; -.
DR UCSC; uc001spe.4; human. [Q8NG04-1]
DR CTD; 65012; -.
DR DisGeNET; 65012; -.
DR GeneCards; SLC26A10; -.
DR HGNC; HGNC:14470; SLC26A10.
DR neXtProt; NX_Q8NG04; -.
DR PharmGKB; PA37887; -.
DR eggNOG; KOG0236; Eukaryota.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; Q8NG04; -.
DR OrthoDB; 690428at2759; -.
DR PhylomeDB; Q8NG04; -.
DR TreeFam; TF313784; -.
DR PathwayCommons; Q8NG04; -.
DR BioGRID-ORCS; 65012; 17 hits in 1073 CRISPR screens.
DR ChiTaRS; SLC26A10; human.
DR GenomeRNAi; 65012; -.
DR Pharos; Q8NG04; Tdark.
DR PRO; PR:Q8NG04; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NG04; protein.
DR Genevisible; Q8NG04; HS.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR030324; SLC26A10.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF99; PTHR11814:SF99; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antiport; Chloride; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..563
FT /note="Solute carrier family 26 member 10"
FT /id="PRO_0000344230"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 406..541
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT VAR_SEQ 410..454
FT /note="LLQVPGLCILSYPTPLYFGTRGQFRCNLEWHLGLGEGEKETSKPD -> AVW
FT MVTWVAVVTLSVDLGLAVGVVFSMMTVVCRTRSSSRSRGSAS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034748"
FT VAR_SEQ 455..563
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034749"
FT VARIANT 130
FT /note="M -> T (in dbSNP:rs971209)"
FT /id="VAR_045599"
FT VARIANT 193
FT /note="A -> T (in dbSNP:rs923828)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_045600"
FT VARIANT 270
FT /note="L -> S (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_045678"
FT VARIANT 546
FT /note="L -> V (in dbSNP:rs774895)"
FT /id="VAR_045601"
SQ SEQUENCE 563 AA; 60059 MW; 6C7380C7E4E2CC99 CRC64;
MRLDLASLMS APKSLGSAFK SWRLDKAPSP QHTFPSTSIP GMAFALLASV PPVFGLYTSF
FPVLIYSLLG TGRHLSTGTF AILSLMTGSA VERLVPEPLV GNLSGIEKEQ LDAQRVGVAA
AVAFGSGALM LGMFVLQLGV LSTFLSEPVV KALTSGAALH VLLSQLPSLL GLSLPRQIGC
FSLFKTLASL LTALPRSSPA ELTISALSLA LLVPVKELNV RFRDRLPTPI PGEVVLVLLA
SVLCFTSSVD TRYQVQIVGL LPGGFPQPLL PNLAELPRIL ADSLPIALVS FAVSASLASI
HADKYSYTID SNQEFLAHGA SNLISSLFSC FPNSATLATT NLLVDAGGKT QLAGLFSCTV
VLSVLLWLGP FFYYLPKAVL ACINISSMRQ VFCQMQELPQ LWHISRVDFL LQVPGLCILS
YPTPLYFGTR GQFRCNLEWH LGLGEGEKET SKPDGPMVAV AEPVRVVVLD FSGVTFADAA
GAREVVQVRE RLASRCRDAR IRLLLAQCNA LVQGTLTRVG LLDRVTPDQL FVSVQDAAAY
ALGSLLRGSS TRSGSQEALG CGK
