S2610_MOUSE
ID S2610_MOUSE Reviewed; 676 AA.
AC Q5EBI0; A0A1Y7VKB5;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2020, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Solute carrier family 26 member 10;
GN Name=Slc26a10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Chloride/bicarbonate exchanger. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH89587.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AC144852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC089587; AAH89587.1; ALT_SEQ; mRNA.
DR CCDS; CCDS48714.2; -.
DR AlphaFoldDB; Q5EBI0; -.
DR SMR; Q5EBI0; -.
DR STRING; 10090.ENSMUSP00000092904; -.
DR PhosphoSitePlus; Q5EBI0; -.
DR MaxQB; Q5EBI0; -.
DR PaxDb; Q5EBI0; -.
DR PRIDE; Q5EBI0; -.
DR Ensembl; ENSMUST00000222911; ENSMUSP00000152871; ENSMUSG00000040441.
DR MGI; MGI:2143920; Slc26a10.
DR VEuPathDB; HostDB:ENSMUSG00000040441; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01050000244807; -.
DR InParanoid; Q5EBI0; -.
DR PhylomeDB; Q5EBI0; -.
DR PRO; PR:Q5EBI0; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5EBI0; protein.
DR Bgee; ENSMUSG00000040441; Expressed in heart and 66 other tissues.
DR ExpressionAtlas; Q5EBI0; baseline and differential.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR030324; SLC26A10.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF99; PTHR11814:SF99; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Antiport; Chloride; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..676
FT /note="Solute carrier family 26 member 10"
FT /id="PRO_0000344231"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 539..660
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 73200 MW; ADDDE2467CF5828D CRC64;
MSGPLASGTC SDPEEVSDLK SPLSSRFREP LTHARFQELF GGAEPEPELP AEPCLPCLCR
LRRRRASACS GPGAWRVLLA RLPPLRWLPQ YRWRAWLLGD AVAGVTVGVV HVPQGMAFAL
LTSVPPVFGL YTSFFPVLIY SLLGTGRHLS TGTFAVLSLM TGSVVERVVP EPLAGNLSGI
EREQLEARRV GAAAAVAFGS GALMLGMFVL QLGVLSTFLS EPVIKALTSG AALHVLVSQL
PSLLGLSLPR QIGCFSLFKT LAAVLSALSQ SSPAEVTISA LSLVLLVPVK ELNVRFRDRL
LTPIPGEVVM VLLATVLCFT SSLDTRYNVQ VVGPLPGGFP QPLLPTLDEL PRILADSLPI
SLVTFAVSTS LASIYADKYS YTIEPNQELL AHGVSNLISS LFSCFPNSAT LATTSLLVDA
GGNTQLAGLF SCAVVLAALL WLRPFFYYLP KAVLACINIS SMRQMFFQMQ ELPQLWHISH
VDFAVWIVTW VAVVTLNVDL GLAVGVVVSM MTVVCRTQRV QCLELGLAEG TELYRPIRES
RKLLQVPGLC ILSYPAPLYF ATRGQFHRIL EWHLGLGERI KPGAEPVRVA ILDFSGITFV
DAAGAREVVQ LTRRCQDDGI YLLLAQCNAL VLETLTRARL LDSVSPEQLF VSVQDAAAHA
LERLKPTGPK ICTVWV
