S2611_BOVIN
ID S2611_BOVIN Reviewed; 602 AA.
AC Q58DD2; A6QPG7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Sodium-independent sulfate anion transporter;
DE AltName: Full=Solute carrier family 26 member 11;
GN Name=SLC26A11 {ECO:0000312|EMBL:AAX46512.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|EMBL:AAX46512.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2] {ECO:0000312|EMBL:AAI49314.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford {ECO:0000312|EMBL:AAI49314.1};
RC TISSUE=Fetal pons {ECO:0000312|EMBL:AAI49314.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Exhibits sodium-independent sulfate anion transporter
CC activity that may cooperate with SLC26A2 to mediate DIDS-sensitive
CC sulfate uptake into high endothelial venules endothelial cells (HEVEC).
CC {ECO:0000250|UniProtKB:Q86WA9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86WA9};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86WA9}. Lysosome
CC membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q86WA9}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000255}.
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DR EMBL; BT021665; AAX46512.1; -; mRNA.
DR EMBL; BC149313; AAI49314.1; -; mRNA.
DR RefSeq; NP_001014866.1; NM_001014866.1.
DR AlphaFoldDB; Q58DD2; -.
DR SMR; Q58DD2; -.
DR STRING; 9913.ENSBTAP00000020324; -.
DR PaxDb; Q58DD2; -.
DR PRIDE; Q58DD2; -.
DR Ensembl; ENSBTAT00000020324; ENSBTAP00000020324; ENSBTAG00000015276.
DR Ensembl; ENSBTAT00000068446; ENSBTAP00000067075; ENSBTAG00000015276.
DR GeneID; 507491; -.
DR KEGG; bta:507491; -.
DR CTD; 284129; -.
DR VEuPathDB; HostDB:ENSBTAG00000015276; -.
DR VGNC; VGNC:34776; SLC26A11.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01050000244925; -.
DR HOGENOM; CLU_003182_12_2_1; -.
DR InParanoid; Q58DD2; -.
DR OMA; VTNKFPI; -.
DR OrthoDB; 289441at2759; -.
DR TreeFam; TF323537; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000015276; Expressed in hypothalamus and 101 other tissues.
DR ExpressionAtlas; Q58DD2; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0008509; F:anion transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; ISS:UniProtKB.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Anion exchange; Cell membrane; Ion transport; Lysosome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..602
FT /note="Sodium-independent sulfate anion transporter"
FT /id="PRO_0000320685"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..300
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..370
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 392..394
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 416..438
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 460..602
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 466..580
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT CONFLICT 84
FT /note="C -> R (in Ref. 2; AAI49314)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 602 AA; 65350 MW; 8644C22A8AAE4685 CRC64;
MSPPMSPMKP PKGFAPMSCC WSTETMQKWL PFLGWLPDYT WYALKMDFIA GISVGLTVIP
QALAYAEVAG LPPQYGLYSA FMGCFVYFFL GTSRDVTLGP TAIMSLLVSF YTFHEPAYAV
LLAFLTGCIQ LGMGFLRLGL LLDFISCPVI KGFTSAAAII IGFGQIKNLL GLQHIPRQFF
LQVYYTFHNI GETRVGDAVL GLVCMVLLLV LKLMRDHVPP VHPEMPTGVR LSHGLVWTAT
TARNALVVSF AALVAYSFQV TGYQPFVLTG KTPEGLPDAH IPPFSVTTAN GTISFTEMVQ
GMGAGLVVVP LMGLLESIAV AKSFASQNNY RINSNQELLA LGFTNILGSL FSSYPVTGSF
GRTAVNAQSG VCTPAGGLMT GALVLLSLDY LTSLFYYIPK SALAAVIIMA VVPLFDTKIV
KTLWRVKRLD LLPLCVTFLL CFWEVQYGIL AGTLVSVLIL LHSVARPKIQ VSEGPMLVLQ
PASGLHFPAI ETLREALLSR ALETSPPRSV ALDCTHICSI DYTVVLGLGE LLEDFHKRGA
TLALIGLQVP VLRVLLSADL KGVLYFCTLE EAEKYLKQEP GTQPYNGSED SVPEHKIALL
KA
