S2611_HUMAN
ID S2611_HUMAN Reviewed; 606 AA.
AC Q86WA9; B2RCI7; Q86VX1; Q86YX7; Q8IV11; Q8N2I1; Q8NG03;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Sodium-independent sulfate anion transporter;
DE AltName: Full=Solute carrier family 26 member 11;
GN Name=SLC26A11 {ECO:0000312|HGNC:HGNC:14471};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAD66450.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Endothelial cell {ECO:0000312|EMBL:CAD66450.1};
RX PubMed=12626430; DOI=10.1096/fj.02-0787fje;
RA Vincourt J.-B., Jullien D., Amalric F., Girard J.-P.;
RT "Molecular and functional characterization of SLC26A11, a sodium-
RT independent sulfate transporter from high endothelial venules.";
RL FASEB J. 17:890-892(2003).
RN [2] {ECO:0000312|EMBL:AAO26673.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Mount D.B.;
RT "Characterization of Homo sapiens SLC26A11, a putative anion exchanger.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4] {ECO:0000312|EMBL:BAC11496.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thyroid {ECO:0000312|EMBL:BAC11496.1};
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [5] {ECO:0000312|EMBL:AAH47451.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain {ECO:0000312|EMBL:AAH35900.2}, and
RC Hypothalamus {ECO:0000312|EMBL:AAH47451.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6] {ECO:0000305, ECO:0000312|EMBL:AAM92902.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 307-599, AND TISSUE SPECIFICITY.
RX PubMed=11087667; DOI=10.1006/geno.2000.6355;
RA Lohi H., Kujala M., Kerkelae E., Saarialho-Kere U., Kestilae M., Kere J.;
RT "Mapping of five new putative anion transporter genes in human and
RT characterization of SLC26A6, a candidate gene for pancreatic anion
RT exchanger.";
RL Genomics 70:102-112(2000).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC TISSUE=Placenta;
RX PubMed=17897319; DOI=10.1111/j.1600-0854.2007.00643.x;
RA Schroeder B., Wrocklage C., Pan C., Jaeger R., Koesters B., Schaefer H.,
RA Elsaesser H.-P., Mann M., Hasilik A.;
RT "Integral and associated lysosomal membrane proteins.";
RL Traffic 8:1676-1686(2007).
RN [8]
RP REVIEW, AND SUBCELLULAR LOCATION.
RX PubMed=20957757; DOI=10.1002/pmic.201000196;
RA Schroeder B.A., Wrocklage C., Hasilik A., Saftig P.;
RT "The proteome of lysosomes.";
RL Proteomics 10:4053-4076(2010).
RN [9]
RP VARIANT CYS-122.
RX PubMed=22521418; DOI=10.1016/j.ajhg.2012.03.012;
RA Jordan C.T., Cao L., Roberson E.D., Pierson K.C., Yang C.F., Joyce C.E.,
RA Ryan C., Duan S., Helms C.A., Liu Y., Chen Y., McBride A.A., Hwu W.L.,
RA Wu J.Y., Chen Y.T., Menter A., Goldbach-Mansky R., Lowes M.A.,
RA Bowcock A.M.;
RT "PSORS2 is due to mutations in CARD14.";
RL Am. J. Hum. Genet. 90:784-795(2012).
CC -!- FUNCTION: Exhibits sodium-independent sulfate anion transporter
CC activity that may cooperate with SLC26A2 to mediate DIDS-sensitive
CC sulfate uptake into high endothelial venules endothelial cells (HEVEC).
CC {ECO:0000269|PubMed:12626430}.
CC -!- INTERACTION:
CC Q86WA9; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-19115335, EBI-12188413;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12626430};
CC Multi-pass membrane protein {ECO:0000269|PubMed:12626430}. Lysosome
CC membrane; Multi-pass membrane protein {ECO:0000269|PubMed:12626430}.
CC -!- TISSUE SPECIFICITY: Detected in all tissues tested with highest
CC expression observed in brain, kidney, HEVEC and placenta and lowest in
CC pancreas, skeletal muscle, liver, lung and heart.
CC {ECO:0000269|PubMed:11087667, ECO:0000269|PubMed:12626430}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000255}.
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DR EMBL; AJ544073; CAD66450.1; -; mRNA.
DR EMBL; AF345195; AAO26673.1; -; mRNA.
DR EMBL; AK315132; BAG37584.1; -; mRNA.
DR EMBL; AK075248; BAC11496.1; -; mRNA.
DR EMBL; BC035900; AAH35900.2; -; mRNA.
DR EMBL; BC047451; AAH47451.1; -; mRNA.
DR EMBL; AF331524; AAM92902.1; -; mRNA.
DR CCDS; CCDS11771.2; -.
DR RefSeq; NP_001159819.1; NM_001166347.1.
DR RefSeq; NP_001159820.1; NM_001166348.1.
DR RefSeq; NP_001159821.1; NM_001166349.1.
DR RefSeq; NP_775897.3; NM_173626.3.
DR AlphaFoldDB; Q86WA9; -.
DR SMR; Q86WA9; -.
DR BioGRID; 129771; 11.
DR IntAct; Q86WA9; 2.
DR MINT; Q86WA9; -.
DR STRING; 9606.ENSP00000355384; -.
DR TCDB; 2.A.53.1.10; the sulfate permease (sulp) family.
DR iPTMnet; Q86WA9; -.
DR PhosphoSitePlus; Q86WA9; -.
DR SwissPalm; Q86WA9; -.
DR BioMuta; SLC26A11; -.
DR DMDM; 182705284; -.
DR EPD; Q86WA9; -.
DR jPOST; Q86WA9; -.
DR MassIVE; Q86WA9; -.
DR MaxQB; Q86WA9; -.
DR PaxDb; Q86WA9; -.
DR PeptideAtlas; Q86WA9; -.
DR PRIDE; Q86WA9; -.
DR ProteomicsDB; 70139; -.
DR Antibodypedia; 32732; 35 antibodies from 10 providers.
DR DNASU; 284129; -.
DR Ensembl; ENST00000361193.8; ENSP00000355384.3; ENSG00000181045.15.
DR Ensembl; ENST00000411502.7; ENSP00000403998.3; ENSG00000181045.15.
DR Ensembl; ENST00000546047.6; ENSP00000440724.2; ENSG00000181045.15.
DR Ensembl; ENST00000572725.5; ENSP00000459470.1; ENSG00000181045.15.
DR GeneID; 284129; -.
DR KEGG; hsa:284129; -.
DR MANE-Select; ENST00000361193.8; ENSP00000355384.3; NM_001166347.2; NP_001159819.1.
DR UCSC; uc002jyb.3; human.
DR CTD; 284129; -.
DR DisGeNET; 284129; -.
DR GeneCards; SLC26A11; -.
DR HGNC; HGNC:14471; SLC26A11.
DR HPA; ENSG00000181045; Low tissue specificity.
DR MalaCards; SLC26A11; -.
DR MIM; 610117; gene.
DR neXtProt; NX_Q86WA9; -.
DR OpenTargets; ENSG00000181045; -.
DR PharmGKB; PA37888; -.
DR VEuPathDB; HostDB:ENSG00000181045; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01050000244925; -.
DR HOGENOM; CLU_003182_12_2_1; -.
DR InParanoid; Q86WA9; -.
DR OMA; VTNKFPI; -.
DR OrthoDB; 289441at2759; -.
DR PhylomeDB; Q86WA9; -.
DR TreeFam; TF323537; -.
DR PathwayCommons; Q86WA9; -.
DR Reactome; R-HSA-427601; Multifunctional anion exchangers.
DR SignaLink; Q86WA9; -.
DR BioGRID-ORCS; 284129; 11 hits in 1057 CRISPR screens.
DR ChiTaRS; SLC26A11; human.
DR GenomeRNAi; 284129; -.
DR Pharos; Q86WA9; Tdark.
DR PRO; PR:Q86WA9; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q86WA9; protein.
DR Bgee; ENSG00000181045; Expressed in pancreatic ductal cell and 171 other tissues.
DR ExpressionAtlas; Q86WA9; baseline and differential.
DR Genevisible; Q86WA9; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0008509; F:anion transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; TAS:Reactome.
DR GO; GO:0008272; P:sulfate transport; IDA:UniProtKB.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 1: Evidence at protein level;
KW Anion exchange; Cell membrane; Ion transport; Lysosome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..606
FT /note="Sodium-independent sulfate anion transporter"
FT /id="PRO_0000320686"
FT TOPO_DOM 1..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..341
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..374
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..398
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..441
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 463..606
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 470..584
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT VARIANT 122
FT /note="Y -> C (in dbSNP:rs765188926)"
FT /evidence="ECO:0000269|PubMed:22521418"
FT /id="VAR_068239"
FT CONFLICT 14
FT /note="S -> Y (in Ref. 1; CAD66450)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="L -> M (in Ref. 1; CAD66450)"
FT /evidence="ECO:0000305"
FT CONFLICT 324
FT /note="V -> M (in Ref. 6; AAM92902)"
FT /evidence="ECO:0000305"
FT CONFLICT 328
FT /note="F -> S (in Ref. 2; AAO26673)"
FT /evidence="ECO:0000305"
FT CONFLICT 332
FT /note="N -> D (in Ref. 1; CAD66450)"
FT /evidence="ECO:0000305"
FT CONFLICT 415
FT /note="V -> A (in Ref. 2; AAO26673)"
FT /evidence="ECO:0000305"
FT CONFLICT 569
FT /note="Y -> H (in Ref. 2; AAO26673)"
FT /evidence="ECO:0000305"
FT CONFLICT 579
FT /note="H -> R (in Ref. 4; BAC11496)"
FT /evidence="ECO:0000305"
FT CONFLICT 583
FT /note="E -> K (in Ref. 5; AAH35900)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 65299 MW; A0D974B49F16450D CRC64;
MPSSVTALGQ ARSSGPGMAP SACCCSPAAL QRRLPILAWL PSYSLQWLKM DFVAGLSVGL
TAIPQALAYA EVAGLPPQYG LYSAFMGCFV YFFLGTSRDV TLGPTAIMSL LVSFYTFHEP
AYAVLLAFLS GCIQLAMGVL RLGFLLDFIS YPVIKGFTSA AAVTIGFGQI KNLLGLQNIP
RPFFLQVYHT FLRIAETRVG DAVLGLVCML LLLVLKLMRD HVPPVHPEMP PGVRLSRGLV
WAATTARNAL VVSFAALVAY SFEVTGYQPF ILTGETAEGL PPVRIPPFSV TTANGTISFT
EMVQDMGAGL AVVPLMGLLE SIAVAKAFAS QNNYRIDANQ ELLAIGLTNM LGSLVSSYPV
TGSFGRTAVN AQSGVCTPAG GLVTGVLVLL SLDYLTSLFY YIPKSALAAV IIMAVAPLFD
TKIFRTLWRV KRLDLLPLCV TFLLCFWEVQ YGILAGALVS LLMLLHSAAR PETKVSEGPV
LVLQPASGLS FPAMEALREE ILSRALEVSP PRCLVLECTH VCSIDYTVVL GLGELLQDFQ
KQGVALAFVG LQVPVLRVLL SADLKGFQYF STLEEAEKHL RQEPGTQPYN IREDSILDQK
VALLKA
