S26A1_MOUSE
ID S26A1_MOUSE Reviewed; 704 AA.
AC P58735;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Sulfate anion transporter 1;
DE Short=SAT-1;
DE AltName: Full=Solute carrier family 26 member 1;
GN Name=Slc26a1; Synonyms=Sat1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP FUNCTION.
RX PubMed=12217875; DOI=10.1152/ajprenal.00079.2002;
RA Xie Q., Welch R., Mercado A., Romero M.F., Mount D.B.;
RT "Molecular characterization of the murine Slc26a6 anion exchanger:
RT functional comparison with Slc26a1.";
RL Am. J. Physiol. 283:F826-F838(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-587, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-587, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF ALA-56; THR-190 AND
RP SER-363.
RX PubMed=27210743; DOI=10.1016/j.ajhg.2016.03.026;
RA Gee H.Y., Jun I., Braun D.A., Lawson J.A., Halbritter J., Shril S.,
RA Nelson C.P., Tan W., Stein D., Wassner A.J., Ferguson M.A., Gucev Z.,
RA Sayer J.A., Milosevic D., Baum M., Tasic V., Lee M.G., Hildebrandt F.;
RT "Mutations in SLC26A1 Cause Nephrolithiasis.";
RL Am. J. Hum. Genet. 98:1228-1234(2016).
CC -!- FUNCTION: Mediates sulfate transport with high affinity
CC (PubMed:12217875, PubMed:27210743). Mediates oxalate transport
CC (PubMed:12217875). Mediates bicarbonate transport (PubMed:27210743).
CC Does not accept succinate as cosubstrate (By similarity).
CC {ECO:0000250|UniProtKB:P45380, ECO:0000269|PubMed:12217875,
CC ECO:0000269|PubMed:27210743}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27210743};
CC Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane
CC {ECO:0000250|UniProtKB:P45380}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; BC032151; AAH32151.1; -; mRNA.
DR EMBL; BC022130; AAH22130.1; -; mRNA.
DR EMBL; BC025824; AAH25824.1; -; mRNA.
DR CCDS; CCDS19517.1; -.
DR RefSeq; NP_001297621.1; NM_001310692.1.
DR RefSeq; NP_777359.3; NM_174870.4.
DR RefSeq; XP_006534974.1; XM_006534911.1.
DR RefSeq; XP_011247743.1; XM_011249441.2.
DR RefSeq; XP_017176343.1; XM_017320854.1.
DR RefSeq; XP_017176344.1; XM_017320855.1.
DR RefSeq; XP_017176345.1; XM_017320856.1.
DR AlphaFoldDB; P58735; -.
DR SMR; P58735; -.
DR BioGRID; 231138; 7.
DR STRING; 10090.ENSMUSP00000051561; -.
DR BindingDB; P58735; -.
DR ChEMBL; CHEMBL2176770; -.
DR GlyGen; P58735; 3 sites.
DR iPTMnet; P58735; -.
DR PhosphoSitePlus; P58735; -.
DR SwissPalm; P58735; -.
DR jPOST; P58735; -.
DR PaxDb; P58735; -.
DR PRIDE; P58735; -.
DR ProteomicsDB; 256871; -.
DR Antibodypedia; 8230; 106 antibodies from 27 providers.
DR DNASU; 231583; -.
DR Ensembl; ENSMUST00000051757; ENSMUSP00000051561; ENSMUSG00000046959.
DR Ensembl; ENSMUST00000163328; ENSMUSP00000131282; ENSMUSG00000046959.
DR GeneID; 231583; -.
DR KEGG; mmu:231583; -.
DR UCSC; uc008yoy.3; mouse.
DR CTD; 10861; -.
DR MGI; MGI:2385894; Slc26a1.
DR VEuPathDB; HostDB:ENSMUSG00000046959; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01050000244925; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; P58735; -.
DR PhylomeDB; P58735; -.
DR TreeFam; TF313784; -.
DR Reactome; R-MMU-174362; Transport and synthesis of PAPS.
DR Reactome; R-MMU-427601; Multifunctional anion exchangers.
DR BioGRID-ORCS; 231583; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Slc26a1; mouse.
DR PRO; PR:P58735; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P58735; protein.
DR Bgee; ENSMUSG00000046959; Expressed in right kidney and 67 other tissues.
DR ExpressionAtlas; P58735; baseline and differential.
DR Genevisible; P58735; MM.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IDA:UniProtKB.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0006821; P:chloride transport; IDA:UniProtKB.
DR GO; GO:0019532; P:oxalate transport; IDA:UniProtKB.
DR GO; GO:0008272; P:sulfate transport; IDA:UniProtKB.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR030331; SLC26A1.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF31; PTHR11814:SF31; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 1: Evidence at protein level;
KW Anion exchange; Antiport; Cell membrane; Glycoprotein; Ion channel;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..704
FT /note="Sulfate anion transporter 1"
FT /id="PRO_0000080156"
FT TRANSMEM 68..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..499
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 532..690
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT MOD_RES 13
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P45380"
FT MOD_RES 587
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 590
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P45380"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 588
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT MUTAGEN 56
FT /note="A->T: Decreased transporter activity. Does not
FT affect localization to plasma membrane."
FT /evidence="ECO:0000269|PubMed:27210743"
FT MUTAGEN 190
FT /note="T->M: Decreased transporter activity. Loss of
FT localization to plasma membrane."
FT /evidence="ECO:0000269|PubMed:27210743"
FT MUTAGEN 363
FT /note="S->L: Decreased transporter activity. Increased
FT accumulation of protein in ER."
FT /evidence="ECO:0000269|PubMed:27210743"
SQ SEQUENCE 704 AA; 75788 MW; A6FA988522A6160A CRC64;
MDASPEPQQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV QGLFPAIHWL
PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY SLYTSFFANL IYFLMGTSRH
VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ DSLGPKNNDS TLNNSATTLI IGLQDCRRDC
YAIRVATALT LMAGLYQVLM GILRLGFVST YLSQPLLDGF AMGASVTILT SQAKHMLGVQ
IPRHQGLGMV VHTWLSLLQN VGQANICDVV TSALCLGVLL AAKELSDRYR HRLKVPIPTE
LFVIVVATIV SHFGQLHTRF DSRVAGNIPT GFVAPQVPDP KIMWRVALDA MSLALVGSAF
SISLAEMFAR SHGYSVSANQ ELLAVGCCNV LPAFFHCFAT SAALSKTLVK IATGCQTQLS
SVVSAAVVLL VLLVLAPLFH DLQRCVLACI IVVSLRGALR KVKDLPQLWR LSPADALVWV
ATAATCVLVS TEAGLLAGVF FSLLSLAGRT QRPRAALLAR IGDSTFYEDA AEFEGLLPPP
EVRVFRFTGP LYYANKDFFL RSLYRLTGLD AGHSATRKDQ GPEVGVSNRS LVDGKDLGSV
SSGAGLVVPL AFGFHTVVID CAPLLFLDVA GMATLKDLRR DYRALDITLL LACCSPSVRD
TLRKGGFLGE EQGAENELLF PSVHSAVEAA CARREELLAA DSAL
