S26A2_BOVIN
ID S26A2_BOVIN Reviewed; 734 AA.
AC Q9BEG8;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Sulfate transporter;
DE AltName: Full=Solute carrier family 26 member 2;
GN Name=SLC26A2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-520.
RX PubMed=14597181; DOI=10.1016/s0378-1119(03)00806-0;
RA Brenig B., Baumgartner B.G., Kriegesmann B., Habermann F., Fries R.,
RA Swalve H.H.;
RT "Molecular cloning, mapping, and functional analysis of the bovine sulfate
RT transporter SLC26a2 gene.";
RL Gene 319:161-166(2003).
CC -!- FUNCTION: Sulfate transporter. May play a role in endochondral bone
CC formation. {ECO:0000250|UniProtKB:P50443}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50443};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; AJ223615; CAB69640.1; -; Genomic_DNA.
DR RefSeq; NP_001035615.1; NM_001040525.1.
DR AlphaFoldDB; Q9BEG8; -.
DR SMR; Q9BEG8; -.
DR STRING; 9913.ENSBTAP00000019462; -.
DR PaxDb; Q9BEG8; -.
DR GeneID; 513953; -.
DR KEGG; bta:513953; -.
DR CTD; 1836; -.
DR eggNOG; KOG0236; Eukaryota.
DR InParanoid; Q9BEG8; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0001503; P:ossification; IEA:InterPro.
DR GO; GO:1902358; P:sulfate transmembrane transport; ISS:UniProtKB.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR030280; SLC26A2.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF16; PTHR11814:SF16; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..734
FT /note="Sulfate transporter"
FT /id="PRO_0000380690"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 519..539
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 563..714
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P50443"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P50443"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 520
FT /note="I -> S (3-fold reduction in the uptake of sulfate by
FT fibroblasts)"
FT /evidence="ECO:0000269|PubMed:14597181"
SQ SEQUENCE 734 AA; 81540 MW; D5224A27EA5D691E CRC64;
MSLKNEDQND LSPKDSVKGN DQYRAPSGIH LEPEEESRND FWQFEPSNLF RHPRIHLEPQ
EKSDNNFKKF VIKKLEKSCQ CSSTKAKNTI FGFLPVLQWL PKYDLKKNIL GDVMSGLIVG
ILLVPQSIAY SLLAGQEPIY GLYTSFFASL IYFILGTSRH ISVGIFGILC LMIGEVVDRE
LYIAGYDTVH AASNESSLVN QISDKTCDRS CYAIIVGSTV TFVAGVYQVA MGFFQVGFVS
VYLSDALLGG FVTGASFTIL TSQVKYLLGL SLPRSAGVGS LITTWLHVFR NIRKTNICDL
ITSLLCLLVL LPTKELNERF KSKLKAPIPV ELFVIVAATL ASHFGKLNEK YGTSIAGHIP
TGFMPPKAPD WNLIPRVAVD AIAIAIIGFA ITVSLSEMFA KKHGYTVKAN QEMYAIGFCN
IIPSFFHCFT TSAALAKTLV KESTGCQTQV SGVMTALVLL LVLLVIAPLF FSLQKSVLGV
ITIVNLRGAL CKFKDLPQMW RISRMDTVIW FVTMLSSALI STEIGLLTGV CFSMFCVILR
TQKPKASLLG LVEDSEVFES MSAYKNLQAK SGIKIFRFVA PLYYVNKEYF KSVLYKKTLN
PVLVKAAQRK AAKRKIKRET VTPSGIQDEV SVQLSHDPLE FHTIVIDCSA IQFLDTAGIH
TLKEVRRDYE AVGIQVLLAQ CNPSVRDSLA RGEYCKKDEE NLLFYSIYEA MTFAEDSQNQ
KERHIPNGPN FSSD
