ID   S26A2_BUBBU             Reviewed;         733 AA.
AC   Q69DJ1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Sulfate transporter;
DE   AltName: Full=Solute carrier family 26 member 2;
GN   Name=SLC26A2;
OS   Bubalus bubalis (Domestic water buffalo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bubalus.
OX   NCBI_TaxID=89462;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kierstein G., Iannuzzi L., Silva A., Schneider M.P., Brenig B.;
RT   "Assignment of solute carrier family 26 (sulfate transporter), member 2
RT   (SLC26a2) to river buffalo (Bubalus bubalis) chromosome 9q26 by
RT   fluorescence in situ hybridization and R-banding.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sulfate transporter. May play a role in endochondral bone
CC       formation. {ECO:0000250|UniProtKB:P50443}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50443};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000305}.
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DR   EMBL; AY350740; AAR06603.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q69DJ1; -.
DR   SMR; Q69DJ1; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015116; F:sulfate transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0001503; P:ossification; IEA:InterPro.
DR   GO; GO:1902358; P:sulfate transmembrane transport; ISS:UniProtKB.
DR   Gene3D; 3.30.750.24; -; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR030280; SLC26A2.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   PANTHER; PTHR11814; PTHR11814; 1.
DR   PANTHER; PTHR11814:SF16; PTHR11814:SF16; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SSF52091; 1.
DR   TIGRFAMs; TIGR00815; sulP; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..733
FT                   /note="Sulfate transporter"
FT                   /id="PRO_0000380691"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        453..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        519..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          563..714
FT                   /note="STAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         12
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P50443"
FT   MOD_RES         16
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P50443"
FT   CARBOHYD        194
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   733 AA;  81419 MW;  7EE7599B8AD8C178 CRC64;
     MSLKNEEQND LSPKDSVKGN DQYRAPSGIH LEREEESRND FWQFEPSNLF RHPRIHLEPQ
     EKSDNNFKKF VIKKLEKSCQ CSSTKAKNTI FGFLPVLQWL PKYDLKKNIL GDVMSGLIVG
     ILLVPQSIAY SLLAGQEPIY GLYTSFFASL IYFILGTSRH ISVGIFGILC LMIGEVVDRE
     LYIAGYDAVH AASNESSLVN QMPDKTCDRS CYAIIVGSTV TFVAGVYQVA MGFFQVGFVS
     VYLSDALLGG FVTGASFTIL TSQVKYLLGL SLPRSAGVGS LITTWIHVFR NIHKTNICDL
     ITSLLCLLVL LPTKELNERF KSKLKAPIPV ELFVVVAATL ASHFGKLNEK YGTSIAGHIP
     TGFMPPEAPD WNLIPRVAID AIAIAIIGFA ITVSLSEMFA KKHGYTVKAN QEMYAIGFCN
     IIPSFFHCFT TSAALAKTLV KESTGCQTQV SGVMTALVLL LVLLVIAPLF FSLQKSVLGV
     ITIVNLRGAL CKFKDLPQMW RISRMDTVIW FVTMLSSALI STEIGLLTGV CFSMFCVILR
     TQKPKASLLG LVEDSEVFES MSAYKNLQAK SGIKIFRFVA PLYYVNKEYF KSVLYKKTLN
     PVLVKAAQRK AAKRKIKRET VTPSGIQDEV SVQLSHDPLE FHTIVIDCSA IQFLDTAGIH
     TLKEVRRDYE AIGIQVLLAQ CNPSVRTPGR GEYCKKDEEN LLFYSVYEAM TFAEDSQNQK
     ETYVPNGPNF SSD