S26A2_HORSE
ID S26A2_HORSE Reviewed; 736 AA.
AC Q65AC2; Q4W444;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Sulfate transporter;
DE AltName: Full=Solute carrier family 26 member 2;
GN Name=SLC26A2;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=15307247; DOI=10.1159/000080191;
RA Brenig B., Beck J., Hall A.J., Broad T.E., Chowdhary B.P., Piumi F.;
RT "Assignment of the equine solute carrier 26A2 gene (SLC26A2) to equine
RT chromosome 14q15-->q21 (ECA14q15-->q21) by in situ hybridization and
RT radiation hybrid panel mapping.";
RL Cytogenet. Genome Res. 107:139-139(2004).
CC -!- FUNCTION: Sulfate transporter. May play a role in endochondral bone
CC formation. {ECO:0000250|UniProtKB:P50443}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50443};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG27693.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ698508; CAG27404.1; -; mRNA.
DR EMBL; AJ698728; CAG27563.1; -; Genomic_DNA.
DR EMBL; AJ698944; CAG27693.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_001075403.1; NM_001081934.2.
DR RefSeq; XP_005599193.1; XM_005599136.2.
DR RefSeq; XP_005599194.1; XM_005599137.2.
DR AlphaFoldDB; Q65AC2; -.
DR SMR; Q65AC2; -.
DR STRING; 9796.ENSECAP00000020821; -.
DR PaxDb; Q65AC2; -.
DR Ensembl; ENSECAT00000025038; ENSECAP00000020821; ENSECAG00000023363.
DR GeneID; 100034141; -.
DR KEGG; ecb:100034141; -.
DR CTD; 1836; -.
DR VGNC; VGNC:55509; SLC26A2.
DR GeneTree; ENSGT01050000244925; -.
DR InParanoid; Q65AC2; -.
DR OrthoDB; 690428at2759; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000023363; Expressed in articular cartilage of joint and 23 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0001503; P:ossification; IEA:InterPro.
DR GO; GO:1902358; P:sulfate transmembrane transport; ISS:UniProtKB.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR030280; SLC26A2.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF16; PTHR11814:SF16; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..736
FT /note="Sulfate transporter"
FT /id="PRO_5000072638"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 526..546
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 570..721
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P50443"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P50443"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 736 AA; 81489 MW; CB81CA27F63B940F CRC64;
MSSESKEPHV LSPKDSFEGN DRYSPPSRIH LELEKKSSTD FKQFEASEPC RPYPRIHMEP
QEKSNTNFKQ FVIKKLQKSC QCSPTKAKNM IFGFLPVLQW LPKYDLKKNI LGDVMSGLIV
GILLVPQSIA YSLLAGQEPI YGLYTSFFAS LIYFLLGTSR HISVGIFGVL CLMIGEVVDR
ELLKAGYDTV HIAPSLGMVS NGSTSLNQTS DRICDRSCYA IKVGSTVTFL AGIYQVAMGF
FQVGFVSVYL SDALLSGFVT GASFTILTSQ AKYLLGLSLP RSSGVGSLIT TWIHIFRNIH
KTNVCDLITS LLCLLVLLPT KELNEHFKSK LKAPIPTELV VVVAATLASH FGKLHEKYNT
SIAGHIPTGF MPPKAPDWNL IPSVAVDAIA ISIIGFAITV SLSEMFAKKH GYTVKANQEM
YAIGFCNIIP SFFHCFTTSA ALAKTLVKES TGCQSQLSGV MTALVLLLVL LVIAPLFYSL
QKSVLGVITI VNLRGALRKF RDLPKMWRVS RMDTVIWFVT MLSSALISTE LGLLIGVCFS
MFCVILRTQK PKVSLLGLVE ETEIFESMSA YKNLQARPGI KIFRFVAPLY YINKECFKSA
LYKKTLNPVL VKAAQKKAAK RKIKKQPVTL SGIQNEISVQ LSHDPLELRT IVIDCSAIQF
LDTAGIHTLK EVRRDYEAIG IQVLLAQCNP SVRDSLARGE YCKDEEENLL FYSVYEAMAF
AEESQNQKGI CIPNGL
