S26A2_RAT
ID S26A2_RAT Reviewed; 739 AA.
AC O70531;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Sulfate transporter;
DE AltName: Full=Diastrophic dysplasia protein homolog;
DE AltName: Full=Solute carrier family 26 member 2;
GN Name=Slc26a2; Synonyms=Dtdst;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Osteosarcoma;
RX PubMed=9575183; DOI=10.1074/jbc.273.20.12307;
RA Satoh H., Susaki M., Shukunami C., Iyama K., Negoro T., Hiraki Y.;
RT "Functional analysis of diastrophic dysplasia sulfate transporter. Its
RT involvement in growth regulation of chondrocytes mediated by sulfated
RT proteoglycans.";
RL J. Biol. Chem. 273:12307-12315(1998).
CC -!- FUNCTION: Sulfate transporter. May play a role in endochondral bone
CC formation. {ECO:0000269|PubMed:9575183}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9575183};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Cartilage and intestine.
CC {ECO:0000269|PubMed:9575183}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; D82883; BAA25987.1; -; mRNA.
DR RefSeq; NP_476468.1; NM_057127.1.
DR RefSeq; XP_006254849.1; XM_006254787.2.
DR RefSeq; XP_006254850.1; XM_006254788.2.
DR RefSeq; XP_017456324.1; XM_017600835.1.
DR AlphaFoldDB; O70531; -.
DR SMR; O70531; -.
DR STRING; 10116.ENSRNOP00000024374; -.
DR GlyGen; O70531; 2 sites.
DR PaxDb; O70531; -.
DR PRIDE; O70531; -.
DR Ensembl; ENSRNOT00000024374; ENSRNOP00000024374; ENSRNOG00000018082.
DR GeneID; 117267; -.
DR KEGG; rno:117267; -.
DR UCSC; RGD:620622; rat.
DR CTD; 1836; -.
DR RGD; 620622; Slc26a2.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01050000244925; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; O70531; -.
DR OMA; ALYWIPK; -.
DR OrthoDB; 690428at2759; -.
DR PhylomeDB; O70531; -.
DR TreeFam; TF313784; -.
DR Reactome; R-RNO-174362; Transport and synthesis of PAPS.
DR Reactome; R-RNO-427601; Multifunctional anion exchangers.
DR PRO; PR:O70531; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000018082; Expressed in jejunum and 18 other tissues.
DR Genevisible; O70531; RN.
DR GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0031528; C:microvillus membrane; IDA:RGD.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IDA:RGD.
DR GO; GO:0001503; P:ossification; IDA:RGD.
DR GO; GO:1902358; P:sulfate transmembrane transport; ISO:RGD.
DR GO; GO:0008272; P:sulfate transport; IDA:RGD.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR030280; SLC26A2.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF16; PTHR11814:SF16; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..739
FT /note="Sulfate transporter"
FT /id="PRO_0000080160"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 568..719
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P50443"
FT CARBOHYD 205
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 357
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 739 AA; 82028 MW; 0C539F66D478C8DA CRC64;
MSSENKEQHN LSPRDLPEEA YGFPPELPLG AQRGSSTDLR QFEPSDRRRA FRRIHMELHE
KPDTNIRQLV MRKLQKSCQC NATKIRNRIF DFFPVLRWLP KYDLKKNILG DMMSGLIVGI
LLVPQSIAYS LLAGQEPIYG LYTSFFASII YFLFGTSRHI SVGIFGILCL MIGEVVDREL
HKACPDIDTT SSSIAMFSNG CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ
VGFVSVYLSD ALLSGFVTGA SFTILTSQAK YLLGLSLPRS NGVGSVITTW IHIFRNIHKT
NICDLITSLL CLLVLVPTKE LNEYFKSKLP APIPTELIVV VAATLASHFG KLNENYNSSI
AGQIPTGFMP PQAPDWSLIP NVAVDAIAIS IIGFAITVSL SEMFAKKHGY TVKANQEMYA
IGFCNIIPSF FHCITTSAAL AKTLVKESTG CQTQLSAIVT SLVLLLVLLL IAPLFYSLQK
CVLGVITIVN LRGALLKFRD LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF
CVILRTQMPK ISLLGLEEES EIFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY
KKTLNPVLVK AAWKKAAKRK LKEETVTFHG DPDEVSMQLS HDPLELHTVV IDCSAIQFLD
TAGIHTLKEV RRDYEAIGIQ VLLAQCNPSV RDSLAKGEYC KKEEENLLFY SLSEAVAFAE
ESQKEKGVCV VNGLSLSGD
