S26A2_SHEEP
ID S26A2_SHEEP Reviewed; 734 AA.
AC Q9GJY3;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Sulfate transporter;
DE AltName: Full=Solute carrier family 26 member 2;
GN Name=SLC26A2;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Kriegesmann B., Baumgartner B.G., Deppe A., Brenig B.;
RT "Sequence of the ovine sulfate transporter gene.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sulfate transporter. May play a role in endochondral bone
CC formation. {ECO:0000250|UniProtKB:P50443}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50443};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; Y18558; CAC20729.1; -; Genomic_DNA.
DR RefSeq; NP_001153228.1; NM_001159756.1.
DR RefSeq; XP_012032939.1; XM_012177549.1.
DR RefSeq; XP_012032941.1; XM_012177551.2.
DR RefSeq; XP_012032942.1; XM_012177552.2.
DR RefSeq; XP_012032943.1; XM_012177553.2.
DR RefSeq; XP_012032944.1; XM_012177554.1.
DR RefSeq; XP_012032945.1; XM_012177555.1.
DR RefSeq; XP_012032946.1; XM_012177556.2.
DR RefSeq; XP_012032948.1; XM_012177558.2.
DR RefSeq; XP_012032949.1; XM_012177559.2.
DR RefSeq; XP_012032950.1; XM_012177560.2.
DR RefSeq; XP_014950958.1; XM_015095472.1.
DR RefSeq; XP_014950959.1; XM_015095473.1.
DR AlphaFoldDB; Q9GJY3; -.
DR SMR; Q9GJY3; -.
DR STRING; 9940.ENSOARP00000006575; -.
DR Ensembl; ENSOART00000006678; ENSOARP00000006575; ENSOARG00000006140.
DR Ensembl; ENSOART00020017243; ENSOARP00020014236; ENSOARG00020011309.
DR GeneID; 100294558; -.
DR KEGG; oas:100294558; -.
DR CTD; 1836; -.
DR eggNOG; KOG0236; Eukaryota.
DR HOGENOM; CLU_003182_9_4_1; -.
DR OMA; ALYWIPK; -.
DR OrthoDB; 690428at2759; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000006140; Expressed in adult mammalian kidney and 55 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0001503; P:ossification; IEA:InterPro.
DR GO; GO:1902358; P:sulfate transmembrane transport; ISS:UniProtKB.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR030280; SLC26A2.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF16; PTHR11814:SF16; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..734
FT /note="Sulfate transporter"
FT /id="PRO_0000380692"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 519..539
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 563..714
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P50443"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P50443"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 734 AA; 81440 MW; 35EABDFB4F2F3B36 CRC64;
MSLKNGEQND LSPKDSVKGN DQYRSPSGIH VEHEEESRND FWQFESSNLF RHPRIHLEPQ
EKSDNNLKKF VIKKLEKSCQ CSSTKAKNTI FGFLPVLQWL PKYDLKKNIL GDMMSGLIVG
ILLVPQSIAY SLLAGQEPIY GLYTSFFASL IYFILGTSRH ISVGIFGILC LMIGEVVDRE
LYIAGYDTVH AASNESSLVN QMSNQTCDRS CYAITVGSTV TFVAGVYQVA MGFFQVGFVS
VYLSDALLGG FVTGASFTIL TSQVKYLLGL SLPRSGGVGS LITTWIHIFR NIHKTNICDL
ITSLLCLLVL LPTKELNERF KSKLKAPIPV ELFVVVAATL ASHFGKLSEK YGTSIAGHIP
TGFMPPKAPD WNLIPRVAVD AIAIAIIGFA ITVSLSEMFA KKHGYTVKAN QEMYAIGFCN
IIPSFFHSFT TSAALAKTLV KESTGCQTQV SGVMTALVLL LVLLVIAPLF FSLQKSVLGV
ITIVNLRGAL CKFKDLPQMW RISRMDTVIW FVTMLSSALI STEIGLLTGV CFSMFCVILR
TQKPKASLLG LVEDSEVFES MSAYKNLQAK SGIKIFRFVA PLYYVNKEYF KSVLYKKTLN
PVLVKAAQRK AAKKKIKRET VTLSGIQDEV SVQLSYDPLE FHTIVIDCSA IQFLDTAGIH
TLKEVRRDYE AIGIQVLLAQ CNPSVRDSLA RGEYCKKDEE NLLFYSVYEA MTFAEDSQNQ
KERYVPNGPS FSSD
