S26A4_MOUSE
ID S26A4_MOUSE Reviewed; 780 AA.
AC Q9R155;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Pendrin;
DE AltName: Full=Sodium-independent chloride/iodide transporter;
DE AltName: Full=Solute carrier family 26 member 4;
GN Name=Slc26a4; Synonyms=Pds;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ;
RX PubMed=10449762; DOI=10.1073/pnas.96.17.9727;
RA Everett L.A., Morsli H., Wu D.K., Green E.D.;
RT "Expression pattern of the mouse ortholog of the Pendred's syndrome gene
RT (Pds) suggests a key role for pendrin in the inner ear.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:9727-9732(1999).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=11459928; DOI=10.1073/pnas.141241098;
RA Knauf F., Yang C.L., Thomson R.B., Mentone S.A., Giebisch G., Aronson P.S.;
RT "Identification of a chloride-formate exchanger expressed on the brush
RT border membrane of renal proximal tubule cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9425-9430(2001).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:11459928}; Multi-
CC pass membrane protein {ECO:0000305|PubMed:11459928}. Cell membrane
CC {ECO:0000269|PubMed:11459928}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:11459928}. Note=Localizes to the apical brush
CC border of cells in the cortical collecting ducts of the kidney.
CC -!- TISSUE SPECIFICITY: Throughout the endolymphatic duct and sac, in
CC distinct areas of the utricle and saccule, and in the external sulcus
CC region within the cochlea. {ECO:0000269|PubMed:10449762}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; AF167411; AAD51617.1; -; mRNA.
DR CCDS; CCDS36429.1; -.
DR RefSeq; NP_035997.1; NM_011867.3.
DR RefSeq; XP_006515154.1; XM_006515091.1.
DR RefSeq; XP_006515155.1; XM_006515092.3.
DR RefSeq; XP_017170557.1; XM_017315068.1.
DR AlphaFoldDB; Q9R155; -.
DR SMR; Q9R155; -.
DR STRING; 10090.ENSMUSP00000001253; -.
DR BindingDB; Q9R155; -.
DR ChEMBL; CHEMBL4523483; -.
DR TCDB; 2.A.53.2.4; the sulfate permease (sulp) family.
DR iPTMnet; Q9R155; -.
DR PhosphoSitePlus; Q9R155; -.
DR jPOST; Q9R155; -.
DR MaxQB; Q9R155; -.
DR PaxDb; Q9R155; -.
DR PRIDE; Q9R155; -.
DR ProteomicsDB; 260894; -.
DR Antibodypedia; 31372; 169 antibodies from 25 providers.
DR DNASU; 23985; -.
DR Ensembl; ENSMUST00000001253; ENSMUSP00000001253; ENSMUSG00000020651.
DR GeneID; 23985; -.
DR KEGG; mmu:23985; -.
DR UCSC; uc007nho.1; mouse.
DR CTD; 5172; -.
DR MGI; MGI:1346029; Slc26a4.
DR VEuPathDB; HostDB:ENSMUSG00000020651; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01050000244807; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; Q9R155; -.
DR OMA; KMEQCGF; -.
DR OrthoDB; 690428at2759; -.
DR PhylomeDB; Q9R155; -.
DR TreeFam; TF313784; -.
DR Reactome; R-MMU-427601; Multifunctional anion exchangers.
DR BioGRID-ORCS; 23985; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Slc26a4; mouse.
DR PRO; PR:Q9R155; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9R155; protein.
DR Bgee; ENSMUSG00000020651; Expressed in ciliary body and 49 other tissues.
DR Genevisible; Q9R155; MM.
DR GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
DR GO; GO:0031526; C:brush border membrane; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0008509; F:anion transmembrane transporter activity; ISS:MGI.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; ISO:MGI.
DR GO; GO:0015111; F:iodide transmembrane transporter activity; ISO:MGI.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; ISS:MGI.
DR GO; GO:0015698; P:inorganic anion transport; ISO:MGI.
DR GO; GO:0006885; P:regulation of pH; IMP:UniProtKB.
DR GO; GO:0032880; P:regulation of protein localization; IMP:UniProtKB.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR030285; Pendrin.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF33; PTHR11814:SF33; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Chloride; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..780
FT /note="Pendrin"
FT /id="PRO_0000080165"
FT TOPO_DOM 1..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..263
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 366..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..421
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..448
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 470..486
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 508..780
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 535..729
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
SQ SEQUENCE 780 AA; 85687 MW; 4988BB48F057BF38 CRC64;
MAARGGRSEP PQLAEYSCSY TVSRPVYSEL AFQQQRERRL PERRTLRDSL ARSCSCSRKR
AFGVVKTLLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL QGMAYALLAA VPVQFGLYSA
FFPILTYFVF GTSRHISVGP FPVVSLMVGS VVLSMAPDDH FLVPSGNGSA LNSTTLDTGT
RDAARVLLAS TLTLLVGIIQ LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL
NVSTKNYNGI LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHRIPVPI
PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPSGFLPPVL PSVGLFSDML AASFSIAVVA
YAIAVSVGKV YATKHDYVID GNQEFIAFGI SNVFSGFFSC FVATTALSRT AVQESTGGKT
QVAGLISAVI VMVAIVALGR LLEPLQKSVL AAVVIANLKG MFMQVCDVPR LWKQNKTDAV
IWVFTCIMSI ILGLDLGLLA GLLFALLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE
EPEGVKILRF SSPIFYGNVD GFKKCINSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT
KNGIISDIGS SNNAFEPDED VEEPEELNIP TKEIEIQVDW NSELPVKVNV PKVPIHSLVL
DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL EKMEQCGFFD DNIRKDRFFL
TVHDAILHLQ NQVKSREGQD SLLETVARIR DCKDPLDLME AEMNAEELDV QDEAMRRLAS
