S26A7_PONAB
ID S26A7_PONAB Reviewed; 656 AA.
AC Q5RAL2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Anion exchange transporter;
DE AltName: Full=Solute carrier family 26 member 7;
GN Name=SLC26A7 {ECO:0000250|UniProtKB:Q8TE54};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1] {ECO:0000312|EMBL:CAH91198.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000312|EMBL:CAH91198.1};
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a sodium-independent DIDS-sensitive anion exchanger
CC mediating bicarbonate, chloride, sulfate and oxalate transport. May
CC play a role in the maintenance of the electrolyte and acid-base
CC homeostasis in the kidney, by acting as a distal excretory segment-
CC specific anion exchanger, specifically chloride. Plays a major role in
CC gastric acid secretion (By similarity). {ECO:0000250|UniProtKB:Q8TE54}.
CC -!- SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250|UniProtKB:Q8TE54}. Note=Expressed in
CC the cytoplasm in recycling endosomes of medullary collecting duct cells
CC and in acid-secreting gastric parietal cells. Targeted to the
CC basolateral membrane in hypertonicity and potassium depletion (By
CC similarity). {ECO:0000250|UniProtKB:Q8TE54}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000255}.
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DR EMBL; CR859003; CAH91198.1; -; mRNA.
DR AlphaFoldDB; Q5RAL2; -.
DR SMR; Q5RAL2; -.
DR STRING; 9601.ENSPPYP00000021021; -.
DR eggNOG; KOG0236; Eukaryota.
DR InParanoid; Q5RAL2; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0001696; P:gastric acid secretion; IEA:InterPro.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR030329; SLC26A7.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF75; PTHR11814:SF75; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Anion exchange; Endosome; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..656
FT /note="Anion exchange transporter"
FT /id="PRO_0000320683"
FT TOPO_DOM 1..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..146
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..254
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..343
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..383
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..448
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 470..656
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 492..641
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 641..656
FT /note="Membrane targeting"
FT /evidence="ECO:0000250|UniProtKB:Q8TE54"
SQ SEQUENCE 656 AA; 72223 MW; 8FCAD18D5EC08616 CRC64;
MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD TVSGIMLAVQ
QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGRHVA TGTFALTSLI SANAVERIVP
QNMQNLTTQS NTSVLGLSDF EMQRIRVAAA VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS
AMTTGAATHV VTSQVKYLLG MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV
LVLVKELNEQ FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP
PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS NIVSSFFFCI
PSAAAMGRTA GLYSTGAKTQ VACLISCIFI LIVIYAIGPL LYWLPMCVLA SIIVVGLKGM
LIQFRDLKKY WNVHKIDWGI WVSTYVFTIC FAANVGLLFG VVCTIAVVIG RFPRTMTVSI
KNMKEMEFKV KTEMDSETLQ QVKIISINNP LVFLNAKKFY TDLMNIIQKE NACNQPLDDI
SKCEQNTLLN SLSNGNCNEE TSQSCPNEKC SLILDCSGFT FFDYSGVSML VEVYMDSKGR
SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL SDHSEV
