ID   S26A7_RABIT             Reviewed;         128 AA.
AC   Q8HY59;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Anion exchange transporter;
DE   AltName: Full=Solute carrier family 26 member 7;
DE   Flags: Fragment;
GN   Name=SLC26A7 {ECO:0000312|EMBL:AAN86026.1};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAN86026.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Gastric parietal cell {ECO:0000269|PubMed:12736153};
RX   PubMed=12736153; DOI=10.1152/ajpgi.00454.2002;
RA   Petrovic S., Ju X., Barone S., Seidler U., Alper S.L., Lohi H., Kere J.,
RA   Soleimani M.;
RT   "Identification of a basolateral Cl-/HCO3- exchanger specific to gastric
RT   parietal cells.";
RL   Am. J. Physiol. 284:G1093-G1103(2003).
CC   -!- FUNCTION: Acts as a sodium-independent DIDS-sensitive anion exchanger
CC       mediating bicarbonate, chloride, sulfate and oxalate transport. May
CC       play a role in the maintenance of the electrolyte and acid-base
CC       homeostasis in the kidney, by acting as a distal excretory segment-
CC       specific anion exchanger. Plays a major role in gastric acid secretion
CC       (By similarity). {ECO:0000250|UniProtKB:Q8TE54}.
CC   -!- SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250|UniProtKB:Q8TE54}. Note=Expressed in
CC       the cytoplasm in recycling endosomes of medullary collecting duct cells
CC       and in acid-secreting gastric parietal cells. Targeted to the
CC       basolateral membrane in hypertonicity and potassium depletion (By
CC       similarity). {ECO:0000250|UniProtKB:Q8TE54}.
CC   -!- TISSUE SPECIFICITY: Expressed in gastric epithelium, predominantly in
CC       the gastric parietal cells but also at lower levels in mucosal cells.
CC       {ECO:0000269|PubMed:12736153}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000255}.
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DR   EMBL; AY166770; AAN86026.1; -; mRNA.
DR   AlphaFoldDB; Q8HY59; -.
DR   SMR; Q8HY59; -.
DR   STRING; 9986.ENSOCUP00000010792; -.
DR   eggNOG; KOG0236; Eukaryota.
DR   InParanoid; Q8HY59; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0001696; P:gastric acid secretion; IEA:InterPro.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR030329; SLC26A7.
DR   PANTHER; PTHR11814; PTHR11814; 1.
DR   PANTHER; PTHR11814:SF75; PTHR11814:SF75; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
PE   2: Evidence at transcript level;
KW   Anion exchange; Endosome; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           <1..>128
FT                   /note="Anion exchange transporter"
FT                   /id="PRO_0000320684"
FT   TOPO_DOM        <1..14
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..66
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..>128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:AAN86026.1"
FT   NON_TER         128
FT                   /evidence="ECO:0000312|EMBL:AAN86026.1"
SQ   SEQUENCE   128 AA;  13808 MW;  8F76218F6CE08D9D CRC64;
     LFSFKELNEQ FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PRGIPPPRAP
     PMNILSAVIT EAFGVALVGY AASLALAQGS AKKFKYSVDD NQEFLAHGLS NVISSFLFCI
     PSAAAMGR