S26A9_XENTR
ID S26A9_XENTR Reviewed; 794 AA.
AC A4IIF2;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Solute carrier family 26 member 9;
DE AltName: Full=Anion transporter/exchanger protein 9;
GN Name=slc26a9;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DIDS- and thiosulfate- sensitive anion exchanger mediating
CC chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate
CC exchange or chloride-independent bicarbonate extrusion thus assuring
CC bicarbonate secretion. May prefer chloride anions and mediate uncoupled
CC chloride anion transport in an alternate-access mechanism where a
CC saturable binding site is alternately exposed to either one or the
CC other side of the membrane. {ECO:0000250|UniProtKB:Q8BU91}.
CC -!- ACTIVITY REGULATION: Inhibited by ammonium and thiosulfate.
CC {ECO:0000250|UniProtKB:Q8BU91}.
CC -!- SUBUNIT: May form homodimers (in vitro).
CC {ECO:0000250|UniProtKB:Q8BU91}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BU91};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; BC135993; AAI35994.1; -; mRNA.
DR RefSeq; NP_001096210.1; NM_001102740.1.
DR AlphaFoldDB; A4IIF2; -.
DR SMR; A4IIF2; -.
DR STRING; 8364.ENSXETP00000013074; -.
DR PaxDb; A4IIF2; -.
DR DNASU; 100124761; -.
DR GeneID; 100124761; -.
DR KEGG; xtr:100124761; -.
DR CTD; 115019; -.
DR Xenbase; XB-GENE-996559; slc26a9.
DR eggNOG; KOG0236; Eukaryota.
DR InParanoid; A4IIF2; -.
DR OrthoDB; 690428at2759; -.
DR Reactome; R-XTR-427601; Multifunctional anion exchangers.
DR Proteomes; UP000008143; Chromosome 2.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IEA:InterPro.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR030306; SLC26A9.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF17; PTHR11814:SF17; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..794
FT /note="Solute carrier family 26 member 9"
FT /id="PRO_0000324494"
FT TOPO_DOM 1..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 71..96
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 97..100
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 101..109
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 110..129
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 130..142
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 143..160
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 161..189
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 190..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 200..222
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 223..235
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT INTRAMEM 236..244
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 245..252
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 274..284
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 285..297
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 298..332
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 333..356
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 357..363
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 364..377
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 378..388
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 389..398
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 399..403
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 404..417
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 418..429
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 430..455
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 456..459
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 460..474
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 475..477
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TRANSMEM 478..496
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT TOPO_DOM 497..794
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BU91"
FT DOMAIN 517..739
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
SQ SEQUENCE 794 AA; 87172 MW; A37479DE42B1DD95 CRC64;
MNKVRPRYII DRPAYSVELF NEEYEKKIRS YPIGGKARKL FSCSTSKIKN FIFRLFPILS
WLPKYNIKGN LLNDALGGIS AGTIQIPQGM AFALLANLPP VNGLYSSFFP LVVYFFMGGI
PQMVPGTFAV ISIIVGNVCL KLAPESHFQN VTSNGTITNI EAMNTARMHI SATLACLTAI
IQIALSFVQF GFVAIYLSES FIRGFMTAAG LQILISVLKY IFGVSIPPYS GVLAIIYTFI
DICKELPKTN VASLIFALIS TVLLIIVKEL NMKFMHKIRF PIPMEIIIVI VATAVSGSFK
LPERYHMNVV GHIPLGFPSP TVPNVTQWDE MVGTAFSLAI VGYVINLAMG RTLGAKHGFD
VDANQEMLAL GSGNFFGSFF FIHVICCALS VTLAVDGAGG KSQIASFFVM MSVMVTILAL
GTYLNPLPKS VLGALIAVNL KNSLKQLSDP FYLWKKSKLD CLVWLVSFFS TFILGLPYGL
AVGVAFSILV VIFNTQFRNG SSLNQVTATD IYVNPKVYSK VQPIDGIKIV TYCSPLYFAN
SEIFRQKVIK KTGLDPGKVY LSKKKYLKQQ EQELKKKEQK KKRGSLFMKN KTLSLQELQE
DFDGVSPTDS NNNSTVNGTA SAISYISSNT LTSGSQTTEN VQNGFSTPAQ TQDPIIAAPP
IVNFHTVIID MSGVCFVDLM GIKALGKLCT SFQRIGVNVY LADVQAQVYD DIENGGMFAE
GSLDRKHLFI TVHDAVLYAE ANNTGIVNTD SKKKGAGDTE IYITDTQDEI SEDYPNLEEA
MFGSMFQTEI QTAL
