S29A3_BOVIN
ID S29A3_BOVIN Reviewed; 474 AA.
AC A1A4N1;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Equilibrative nucleoside transporter 3;
DE AltName: Full=Solute carrier family 29 member 3;
GN Name=SLC29A3; Synonyms=ENT3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates both influx and efflux of nucleosides across the
CC membrane (equilibrative transporter). Mediates transport of adenine,
CC adenosine and uridine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Late
CC endosome membrane. Lysosome membrane. Note=Intracellular localization
CC shows a partial overlap with late endosomes/lysosomes. Not detected at
CC the cell surface (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000305}.
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DR EMBL; BC126741; AAI26742.1; -; mRNA.
DR RefSeq; NP_001073692.1; NM_001080223.1.
DR AlphaFoldDB; A1A4N1; -.
DR SMR; A1A4N1; -.
DR STRING; 9913.ENSBTAP00000054103; -.
DR PaxDb; A1A4N1; -.
DR PRIDE; A1A4N1; -.
DR GeneID; 504503; -.
DR KEGG; bta:504503; -.
DR CTD; 55315; -.
DR eggNOG; KOG1479; Eukaryota.
DR InParanoid; A1A4N1; -.
DR OrthoDB; 559763at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR030193; ENT3.
DR InterPro; IPR002259; Eqnu_transpt.
DR PANTHER; PTHR10332; PTHR10332; 1.
DR PANTHER; PTHR10332:SF17; PTHR10332:SF17; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR PIRSF; PIRSF016379; ENT; 1.
DR PRINTS; PR01130; DERENTRNSPRT.
PE 2: Evidence at transcript level;
KW Endosome; Glycoprotein; Lysosome; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..474
FT /note="Equilibrative nucleoside transporter 3"
FT /id="PRO_0000376934"
FT TOPO_DOM 1..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..161
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..339
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 358..376
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..414
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 436..453
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 272..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99P65"
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BZD2"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 474 AA; 51646 MW; 1EE54B5461084DBB CRC64;
MAIISEDDFR HTSNSTYRTA SSSLRADQEA LLEKLLDRPP PSLQRPEDRF NGTYIIFFSL
GIGGLLPWNF FVTAQEYWIF KLSNCSSPAA GEEPKDSDIL NYFESYLAVA STVPSVLCLA
LNFLLVNRVP IRVRVLASLT VMLAIFIVMT VLVKVDTSSW THSFFTITIT CMAILSGTST
IFNSSVFGMT GSFPMRNSQA LISGGAMGGT LSAVASLVDL AVASDVTDST LAFFLTADIF
LALCIGLYLL LPRLDYARYY MKPVWPTVFS GEEQLPQDSP SPTSVAPGSS DPQTPPLGPI
LKKTTGLGFC IIYLFFITSL IFPAICTNIE SLSKGSGSPW STKFFVPLTT FLLYNFADLC
GRQVTAWIQV PGPRSKALPG LALLRTCFVP LFVFCNYQPR GHLHTVLFQS DVYPVLFTSL
LGLSNGYLST LALIYGPKIV PRELAEATGV VMTFYMGLGL VLGSACSALL VHLI
