S31A1_HUMAN
ID S31A1_HUMAN Reviewed; 1347 AA.
AC Q5TZJ5; Q5RGS2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Spermatogenesis-associated protein 31A1 {ECO:0000305};
DE AltName: Full=Protein FAM75A1 {ECO:0000305};
GN Name=SPATA31A1 {ECO:0000312|HGNC:HGNC:23394};
GN Synonyms=C9orf36 {ECO:0000312|HGNC:HGNC:23394},
GN FAM75A1 {ECO:0000312|HGNC:HGNC:23394},
GN FAM75A2 {ECO:0000312|HGNC:HGNC:23394},
GN SPATA31A2 {ECO:0000312|HGNC:HGNC:23394};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
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DR EMBL; BX005214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX664726; CAI17100.1; -; Genomic_DNA.
DR CCDS; CCDS43808.2; -.
DR AlphaFoldDB; Q5TZJ5; -.
DR BioGRID; 571847; 1.
DR STRING; 9606.ENSP00000366875; -.
DR iPTMnet; Q5TZJ5; -.
DR PhosphoSitePlus; Q5TZJ5; -.
DR BioMuta; SPATA31A1; -.
DR DMDM; 74746693; -.
DR jPOST; Q5TZJ5; -.
DR MassIVE; Q5TZJ5; -.
DR PaxDb; Q5TZJ5; -.
DR PeptideAtlas; Q5TZJ5; -.
DR PRIDE; Q5TZJ5; -.
DR Antibodypedia; 76540; 7 antibodies from 4 providers.
DR Ensembl; ENST00000377647.6; ENSP00000366875.5; ENSG00000204849.10.
DR MANE-Select; ENST00000377647.6; ENSP00000366875.5; NM_001085452.4; NP_001078921.3.
DR UCSC; uc004abm.4; human.
DR GeneCards; SPATA31A1; -.
DR HGNC; HGNC:23394; SPATA31A1.
DR HPA; ENSG00000204849; Tissue enriched (testis).
DR neXtProt; NX_Q5TZJ5; -.
DR PharmGKB; PA162387841; -.
DR VEuPathDB; HostDB:ENSG00000204849; -.
DR eggNOG; ENOG502RU0E; Eukaryota.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_005668_2_0_1; -.
DR InParanoid; Q5TZJ5; -.
DR OMA; QSESCER; -.
DR PhylomeDB; Q5TZJ5; -.
DR TreeFam; TF338531; -.
DR Pharos; Q5TZJ5; Tdark.
DR PRO; PR:Q5TZJ5; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5TZJ5; protein.
DR Bgee; ENSG00000204849; Expressed in left testis and 8 other tissues.
DR Genevisible; Q5TZJ5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR InterPro; IPR039509; SPATA31/FAM205.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 1.
PE 3: Inferred from homology;
KW Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1347
FT /note="Spermatogenesis-associated protein 31A1"
FT /id="PRO_0000313017"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 55..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..78
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..226
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 88
FT /note="P -> R (in Ref. 1; CAI17100)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="L -> F (in Ref. 1; CAI17100)"
FT /evidence="ECO:0000305"
FT CONFLICT 1063
FT /note="A -> T (in Ref. 1; CAI17100)"
FT /evidence="ECO:0000305"
FT CONFLICT 1099
FT /note="N -> S (in Ref. 1; CAI17100)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1347 AA; 148561 MW; 3643C5C3EDA06FC7 CRC64;
MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFR CDDPPSPSPG
KRKCPVGRRR RPRGRMKNHS LRAGRECPRG LQETSDLLSQ LQSLLGPHLD KGDFGQLSGP
DPPGEVGERA PDGASQSSHE PMEDAAPILS PLASPDPQAK HPQDLASTPS PGPMTTSVSS
LSASQPPEPS LPLEHPSPEP PALFPHPPHT PDPLACSPPP PKGFTAPPLR DSTLITPSHC
DSVALPLGTV PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD
HLSRHPPETY QMEAGSLFLL SSDGQNAVGI QVTETAKVNI WEEKENVGSF TDRMTPEKHL
NSLRNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKLSD PRLWQESFWK NYSQLFWGLP
SLHSESLVAN AWVTDRSYTL QSPPFLFNEM SNVCPIQRET TMSPLLFQAQ PPSHLGPECQ
PFISSTPQFR PTPMAQAEAQ AHLQSSFPVL SPAFPSLIKN TGVACPASQN KVQALSLPET
QHPEWPLLRR QLEGRLALPS RVQKSQDVFS VSTPNLPQES LTSILPENFP VSPELRRQLE
QHIKKWIIQH WGNLGRIQES LDLMQLRDES PGTSQAKGKP SPWQSSMSTG ESSKEAQKVK
FQLERDPCPH LGQILGETPQ NLSRDMKSFP RKVLGVTSEE SERNLRKPLR SDSGSDLLRC
TERTHIENIL KAHMGRNLGQ TNEGLIPVRV RRSWLAVNQA LPVSNTHVKT SNLAAPKSGK
ACVNTAQVLS FLEPCTQQGL GAHIVRFWAK HRWGLPLRVL KPIQCFKLEK VSSLSLTQLA
GPSSATCESG AGSEVEVDMF LRKPPMASLR KQVLTKASDH MPESLLASSP AWKQFQRAPR
GIPSWNDHGP LKPPPAGQEG RWPSKPLTYS LTGSTQQSRS LGAQSSKAGE TREAVPQCRV
PLETCMLANL QATSEDMHGF EAPGTSKSSL HPRVSVSQDP RKLCLMEEVV NEFEPGMATK
SETQPQVCAA VVLLPDGQAS VVPHASENLV SQVPQGHLQS MPAGNMRASQ ELHDLMAARR
SKLVHEEPRN PNCQGSCKNQ RPMFPPIHKS EKSRKPNLEK HEERLEGLRT PQLTPVRKTE
DTHQDEGVQL LPSKKQPPSV SHFGGNIKQF FQWIFSKKKS KPAPVTAESQ KTVKNRSCVY
SSSAEAQGLM TAVGQMLDEK MSLCHARHAS KVNQHKQKFQ APVCGFPCNH RHLFYSEHGR
ILSYAASSQQ ATLKSQGCPN RDRQIRNQQP LKSVRCNNEQ WGLRHPQILH PKKAVSPVSP
LQHWPKTSGA SSHHHHCPRH CLLWEGI
