S31A5_HUMAN
ID S31A5_HUMAN Reviewed; 1347 AA.
AC Q5VU36;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Spermatogenesis-associated protein 31A5;
DE AltName: Full=Protein FAM75A5;
GN Name=SPATA31A5; Synonyms=FAM75A5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
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DR EMBL; AL590491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS47970.1; -.
DR RefSeq; NP_001107013.1; NM_001113541.1.
DR AlphaFoldDB; Q5VU36; -.
DR SMR; Q5VU36; -.
DR iPTMnet; Q5VU36; -.
DR PhosphoSitePlus; Q5VU36; -.
DR BioMuta; SPATA31A5; -.
DR DMDM; 74747037; -.
DR jPOST; Q5VU36; -.
DR MassIVE; Q5VU36; -.
DR PaxDb; Q5VU36; -.
DR PeptideAtlas; Q5VU36; -.
DR PRIDE; Q5VU36; -.
DR ProteomicsDB; 65373; -.
DR DNASU; 727905; -.
DR Ensembl; ENST00000437823.5; ENSP00000485628.1; ENSG00000276581.3.
DR GeneID; 727905; -.
DR KEGG; hsa:727905; -.
DR MANE-Select; ENST00000437823.5; ENSP00000485628.1; NM_001113541.3; NP_001107013.1.
DR UCSC; uc004abu.6; human.
DR CTD; 727905; -.
DR GeneCards; SPATA31A5; -.
DR HGNC; HGNC:32005; SPATA31A5.
DR HPA; ENSG00000276581; Tissue enriched (testis).
DR neXtProt; NX_Q5VU36; -.
DR PharmGKB; PA162387890; -.
DR VEuPathDB; HostDB:ENSG00000276581; -.
DR eggNOG; ENOG502RU0E; Eukaryota.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_005668_2_0_1; -.
DR InParanoid; Q5VU36; -.
DR OMA; CINTSQK; -.
DR OrthoDB; 1095565at2759; -.
DR PhylomeDB; Q5VU36; -.
DR TreeFam; TF338531; -.
DR PathwayCommons; Q5VU36; -.
DR BioGRID-ORCS; 727905; 29 hits in 615 CRISPR screens.
DR GenomeRNAi; 727905; -.
DR Pharos; Q5VU36; Tdark.
DR PRO; PR:Q5VU36; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5VU36; protein.
DR Bgee; ENSG00000276581; Expressed in left testis and 1 other tissue.
DR Genevisible; Q5VU36; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR InterPro; IPR039509; SPATA31/FAM205.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 1.
PE 3: Inferred from homology;
KW Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1347
FT /note="Spermatogenesis-associated protein 31A5"
FT /id="PRO_0000313020"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 55..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1313..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..78
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..226
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1347 AA; 148687 MW; 4C6AEE05722DFAFD CRC64;
MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFR CDDPPSPSPG
KRKCPVGRRR RPRGRMKNHS LRAGRECRRG LEETSDLLSQ LQSLLGPHLD KGDFGQLSGP
DPPGEVGERA PDGASQSSHE PMEDAAPILS PLASPDPQAK HPQDLASTPS PGPMTTSVSS
LSASQPPEPS LPLEHPSPEP PALFPHPPHT PDPLACSLPP PKGFTAPPLR DSTLITPSHC
DSVAFPLGTV PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD
HLSRHPPETC QMEAGSLFLL SSDGQNVVGI QVTETAKVNI WEEKENVGSF TNRMTPEKHL
NSLRNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKLSD PRLWQESFWK NYSQLFWGLP
SLHSESLVAN AWVTDRSYTL QSPPFLFNEM SNVCPIQRET TMSPLLFQAQ PLSHLGPECQ
PFISSTPQFR PTPMAQAEAQ AHLQSSFPVL SPAFPSLIQN TGVACPASQN KVQALSLPET
QHPEWPLLRR QLEGRLALPS RVQKSQDVFS VSTPNLPQES LTSILPENFP VSPELRRQLE
QHIKKWIIQH WGNLGRIQES LDLMQLRDES PGTSQAKGKP SPWQSSMSTG EGSKEAQKVK
FQLERDPCPH LGQILGETPQ NLSRDMKSFP RKVLGVTSEE LERNLRKPLR SDSGSDLLRC
TERTHIENIL KAHMGRNLGQ TNEGLIPVCV RRSWLAVNQA LPVSNTHVKT SNLAAPKSGK
ACVNTAQVLS FLEPCTQQGL GAHIVRFWAK HRWGLPLRVL KPIQCFKLEK VSSLSLTQLA
GPSSATCESG AGSEVEVDMF LRKPPMASLR KQVLTKASDH MPESLLASSP AWKQFQRAPR
GIPSWNDHEP LKPPPAGQEG RWPSKPLTYS LTGSIQQSRS LGAQSSKAGE TREAVPQCRV
PLETCMLANL QATSEDVHGF EAPGTSKSSL HPRVSVSQDP RKLCLMEEVV NEFEPGMATK
SETQPQVCAA VVLLPDGQAS VVPHASENLV SQVPQGHLQS MPTGNMRASQ ELHDLMAARR
SKLVHEEPRN PNCQGSCKSQ RPMFPPIHKS EKSRKPNLEK HEERLEGLRT PQLTPVRKTE
DTHQDEGVQL LPSKKQPPSV SPFGENIKQI FQWIFSKKKS KPAPVTAESQ KTVKNRSRVY
SSSAEAQGLM TAVGQMLDEK MSLCHARHAS KVNQHKQKFQ APVCGFPCNH RHLFYSEHGR
ILSYAASSQQ ATLKSQGCPN RDRQIRNQQP LKSVRCNNEQ WGLRHPQILH PKKAVSPVSP
PQHWPKTSGA SSHHHHCPRH CLLWEGI
