S31A6_HUMAN
ID S31A6_HUMAN Reviewed; 1343 AA.
AC Q5VVP1;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Spermatogenesis-associated protein 31A6;
DE AltName: Full=Protein FAM75A6;
GN Name=SPATA31A6; Synonyms=FAM75A6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
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DR EMBL; AL445584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS75837.1; -.
DR RefSeq; NP_001138668.1; NM_001145196.1.
DR AlphaFoldDB; Q5VVP1; -.
DR STRING; 9606.ENSP00000329825; -.
DR iPTMnet; Q5VVP1; -.
DR PhosphoSitePlus; Q5VVP1; -.
DR BioMuta; SPATA31A6; -.
DR DMDM; 74747270; -.
DR jPOST; Q5VVP1; -.
DR MassIVE; Q5VVP1; -.
DR PaxDb; Q5VVP1; -.
DR PeptideAtlas; Q5VVP1; -.
DR PRIDE; Q5VVP1; -.
DR DNASU; 389730; -.
DR Ensembl; ENST00000332857.7; ENSP00000329825.6; ENSG00000185775.10.
DR GeneID; 389730; -.
DR KEGG; hsa:389730; -.
DR MANE-Select; ENST00000332857.7; ENSP00000329825.6; NM_001145196.1; NP_001138668.1.
DR UCSC; uc033csq.2; human.
DR CTD; 389730; -.
DR GeneCards; SPATA31A6; -.
DR HGNC; HGNC:32006; SPATA31A6.
DR HPA; ENSG00000185775; Tissue enriched (testis).
DR neXtProt; NX_Q5VVP1; -.
DR OpenTargets; ENSG00000185775; -.
DR PharmGKB; PA164719932; -.
DR VEuPathDB; HostDB:ENSG00000185775; -.
DR eggNOG; ENOG502RU0E; Eukaryota.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_005668_2_0_1; -.
DR InParanoid; Q5VVP1; -.
DR OMA; IQHPEWP; -.
DR OrthoDB; 1095565at2759; -.
DR PhylomeDB; Q5VVP1; -.
DR TreeFam; TF338531; -.
DR BioGRID-ORCS; 389730; 305 hits in 1052 CRISPR screens.
DR GenomeRNAi; 389730; -.
DR Pharos; Q5VVP1; Tdark.
DR PRO; PR:Q5VVP1; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5VVP1; protein.
DR Bgee; ENSG00000185775; Expressed in left testis and 6 other tissues.
DR Genevisible; Q5VVP1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR InterPro; IPR039509; SPATA31/FAM205.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 1.
PE 3: Inferred from homology;
KW Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1343
FT /note="Spermatogenesis-associated protein 31A6"
FT /id="PRO_0000297668"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 55..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1309..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..78
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..226
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1343 AA; 147818 MW; C7859D919C26D347 CRC64;
MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFH CDDPPSPSPG
KRKCPVGRRR RPRGRMKNHS LRAGRECPRG LEETSDLLSQ LQSLLGPHLD KGDFGQLSGP
DPPGEVGERA PDGASQSSHE PMEDAAPILS PLASPDPQAK HPQDLASTPS PGPMTTSVSS
LSASQPPEPS LPLEHPSPEP PALFPHPPHT PDPLACSPPP PKGFTAPPLR DSTLITPSHC
DSVALPLGTV PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD
PLSRHPPETC QMEAGSLFLL SSDGQNVVGI QVTETAKVNI WEEKENVGSF TNQMTPEKHL
NSLGNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKCSD PRLLQESFWK NYSQLFWGLP
SLHSESLVAN AWVTDRSYTL QSPPFLFNEM SNVCPIQRET TMSPLLFQAQ PLSHRQPFIS
STPQFLPTPM AQAEAQAHLQ SSFPVLSPAF PSLIKNTGVA CPASQNKVQA LSLPETQHPE
WPLLRKQLEG RLALPSRVQK SQDVFSVSTP NLPQESLTSI LPENFPVSPE LRRQLEQHIK
KWIIQHWGNL GRIQESLDLM QLRDESPGTS QAKGKPSPWQ SSTSTGESSK EAQKVKFQLE
RDLCPHLGQI LGETPQNLSR DMKSFPRKVL GVTSEESERN LRKPLRSDSG SDLLRCTERT
HIENILKAHM GRNLGQTNEG LIPVRVRRSW LAVNQALPVS NTHVKTSNLA APKSGKACVN
TAQVLSFLEP CTQQGLGAHI VRFWAKHRWG LPLRVLKPIQ CFKLEKVSSL SLTQLAGPSS
ATCESGAGSE VEVDMFLRKP PMASLRKQVL TKASDHMPES LLASSPAWKQ FQRAPRGIPS
WNDHGPLKPP PAGQEGRWPS KPLTYSLTGS TQQSRSLGAQ SSKAGETREA VPQCRVPLET
CMLANLQATS EDVHGFEAPG TSKSSLHPRV SVSQDPRKLC LMEEVVSEFE PGMATKSETQ
PQVCAAVVLL PDGQASVVPH ASENLVSQVP QGHLQSMPTG NMRASQELHD LMAARRSKLV
QEEPRNPNCQ GSCKSQRPMF PPIHKSEKSR KPNLEKHEER LEGLRTPQLT PVRKTEDTHQ
DEGVQLLPSK KQPPSVSHFG ENIKQFFQWI FSKKKSKPAP VTAESQKTVK NRSCVYSSSA
EAQGLMTAVG QMLDKKMSLC HAHHASKVNQ HKQKFQAPVC GFPCNHRHLF YSEHGRILSY
AASSQQATLK SQGCPNRDRQ IRNQQPLKSV RCNNEQWGLR HPQILHPKKA VSPVSPPQHW
PKTSGASSHH HHCPRHCLLW EGI
