S31A7_HUMAN
ID S31A7_HUMAN Reviewed; 1347 AA.
AC Q8IWB4; Q4VX67; Q5TZK4; Q9Y4Q5;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 4.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Spermatogenesis-associated protein 31A7 {ECO:0000305};
DE AltName: Full=Protein FAM75A7 {ECO:0000305};
GN Name=SPATA31A7 {ECO:0000312|HGNC:HGNC:32007};
GN Synonyms=FAM75A4 {ECO:0000312|HGNC:HGNC:32007},
GN FAM75A7 {ECO:0000312|HGNC:HGNC:32007},
GN SPATA31A4 {ECO:0000312|HGNC:HGNC:32007};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IWB4; P81534: DEFB103B; NbExp=3; IntAct=EBI-1222614, EBI-12074168;
CC Q8IWB4; A1E959: ODAM; NbExp=3; IntAct=EBI-1222614, EBI-5774125;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH40528.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL596385; CAI95396.1; -; Genomic_DNA.
DR EMBL; BX005040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040528; AAH40528.1; ALT_INIT; mRNA.
DR CCDS; CCDS75838.1; -.
DR PIR; T12532; T12532.
DR RefSeq; NP_056482.2; NM_015667.2.
DR AlphaFoldDB; Q8IWB4; -.
DR BioGRID; 117591; 5.
DR IntAct; Q8IWB4; 3.
DR STRING; 9606.ENSP00000484807; -.
DR iPTMnet; Q8IWB4; -.
DR PhosphoSitePlus; Q8IWB4; -.
DR BioMuta; SPATA31A7; -.
DR DMDM; 166215080; -.
DR jPOST; Q8IWB4; -.
DR MassIVE; Q8IWB4; -.
DR PaxDb; Q8IWB4; -.
DR PeptideAtlas; Q8IWB4; -.
DR PRIDE; Q8IWB4; -.
DR ProteomicsDB; 70834; -.
DR DNASU; 26165; -.
DR Ensembl; ENST00000619167.1; ENSP00000484807.1; ENSG00000276040.4.
DR GeneID; 26165; -.
DR KEGG; hsa:26165; -.
DR MANE-Select; ENST00000619167.2; ENSP00000484807.1; NM_015667.2; NP_056482.2.
DR UCSC; uc033ctg.2; human.
DR CTD; 26165; -.
DR DisGeNET; 26165; -.
DR GeneCards; SPATA31A7; -.
DR HGNC; HGNC:32007; SPATA31A7.
DR HPA; ENSG00000276040; Tissue enriched (testis).
DR MIM; 616584; gene.
DR neXtProt; NX_Q8IWB4; -.
DR PharmGKB; PA162387900; -.
DR VEuPathDB; HostDB:ENSG00000276040; -.
DR eggNOG; ENOG502RU0E; Eukaryota.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_005668_2_0_1; -.
DR InParanoid; Q8IWB4; -.
DR OMA; CDLMSAR; -.
DR OrthoDB; 1095565at2759; -.
DR PhylomeDB; Q8IWB4; -.
DR TreeFam; TF338531; -.
DR PathwayCommons; Q8IWB4; -.
DR SignaLink; Q8IWB4; -.
DR BioGRID-ORCS; 26165; 66 hits in 605 CRISPR screens.
DR GenomeRNAi; 26165; -.
DR Pharos; Q8IWB4; Tdark.
DR PRO; PR:Q8IWB4; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8IWB4; protein.
DR Bgee; ENSG00000276040; Expressed in right testis and 60 other tissues.
DR Genevisible; Q8IWB4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR InterPro; IPR039509; SPATA31/FAM205.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 1.
PE 1: Evidence at protein level;
KW Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1347
FT /note="Spermatogenesis-associated protein 31A7"
FT /id="PRO_0000280245"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 55..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1313..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..78
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..226
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 41
FT /note="L -> V (in Ref. 1; CAI95396)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="C -> S (in Ref. 2; AAH40528)"
FT /evidence="ECO:0000305"
FT CONFLICT 88
FT /note="P -> R (in Ref. 1; CAI95396)"
FT /evidence="ECO:0000305"
FT CONFLICT 297
FT /note="V -> A (in Ref. 2; AAH40528)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="Y -> S (in Ref. 1; CAI95396)"
FT /evidence="ECO:0000305"
FT CONFLICT 472
FT /note="L -> P (in Ref. 2; AAH40528)"
FT /evidence="ECO:0000305"
FT CONFLICT 625
FT /note="Q -> R (in Ref. 2; AAH40528)"
FT /evidence="ECO:0000305"
FT CONFLICT 749
FT /note="C -> R (in Ref. 1; CAI95396)"
FT /evidence="ECO:0000305"
FT CONFLICT 1199
FT /note="V -> A (in Ref. 2; AAH40528)"
FT /evidence="ECO:0000305"
FT CONFLICT 1219
FT /note="E -> K (in Ref. 1; CAI95396)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1347 AA; 148734 MW; BE571EC6050FF9A9 CRC64;
MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFR CDDPPSPSPG
KRKCPVGRRR RPRGRMKNHS LRAGRECPRG LEETSDLLSQ LQSLLGPHLD KGDFGQLSGP
DPPGEVGERA PDGASQSSHE PMEDAAPILS PLASPDPQAK HPQDLASTPS PGPMTTSVSS
LSASQPPEPS LPLEHPSPEP PALFPHPPHT PDPLACSLPP PKGFTAPPLR DSTLITPSHC
DSVAFPLGTV PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD
HLSRHPPETC QMEAGSLFLL SSDGQNVVGI QVTETAKVNI WEEKENVGSF TNRMTPEKHL
NYLRNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKLSD PRLWQESFWK NYSQLFWGLP
SLHSESLVAN AWVTDRSYTL QSPPFLFNEM SNVCPIQRET TMSPLLFQAQ PLSHLGPECQ
PFISSTPQFR PTPMAQAEAQ AHLQSSFPVL SPAFPSLIQN TGVACPASQN KVQALSLPET
QHPEWPLLRR QLEGRLALPS RVQKSQDVFS VSTPNLPQES LTSILPENFP VSPELRRQLE
QHIKKWIIQH WGNLGRIQES LDLMQLRDES PGTSQAKGKP SPWQSSMSTG ESSKEAQKVK
FQLERDPCPH LGQILGETPQ NLSRDMKSFP RKVLGVTSEE LERNLRKPLR SDSGSDLLRC
TERTHIENIL KAHMGRNLGQ TNEGLIPVCV RRSWLAVNQA LPVSNTHVKT SNLAAPKSGK
ACVNTAQVLS FLEPCTQQGL GAHIVRFWAK HRWGLPLRVL KPIQCFKLEK VSSLSLTQLA
GPSSATCESG AGSEVEVDMF LRKPPMASLR KQVLTKASDH MPESLLASSP AWKQFQRAPR
GIPSWNDHEP LKPPPAGQEG RWPSKPLTYS LTGSIQQSRS LGAQSSKAGE TREAVPQCRV
PLETCMLANL QATSEDVHGF EAPGTSKSSL HPRVSVSQDP RKLCLMEEVV NEFEPGMATK
SETQPQVCAA VVLLPDGQAS VVPHASENLV SQVPQGHLQS MPTGNMRASQ ELHDLMAARR
SKLVHEEPRN PNCQGSCKSQ RPMFPPIHKS EKSRKPNLEK HEERLEGLRT PQLTPVRKTE
DTHQDEGVQL LPSKKQPPSV SPFGENIKQI FQWIFSKKKS KPAPVTAESQ KTVKNRSRVY
SSSAEAQGLM TAVGQMLDEK MSLCHARHAS KVNQHKQKFQ APVCGFPCNH RHLFYSEHGR
ILSYAASSQQ ATLKSQGCPN RDRQIRNQQP LKSVRCNNEQ WGLRHPQILH PKKAVSPVSP
PQHWPKTSGA SSHHHHCPRH CLLWEGI
