S31C1_HUMAN
ID S31C1_HUMAN Reviewed; 1188 AA.
AC P0DKV0;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Putative spermatogenesis-associated protein 31C1;
DE AltName: Full=Protein FAM75C1;
GN Name=SPATA31C1; Synonyms=FAM75C1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P0DKV0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0DKV0-2; Sequence=VSP_044951, VSP_044952;
CC -!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AK310310; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL353572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001138596.1; NM_001145124.1. [P0DKV0-1]
DR AlphaFoldDB; P0DKV0; -.
DR SMR; P0DKV0; -.
DR iPTMnet; P0DKV0; -.
DR PhosphoSitePlus; P0DKV0; -.
DR BioMuta; HGNC:27846; -.
DR jPOST; P0DKV0; -.
DR MassIVE; P0DKV0; -.
DR PeptideAtlas; P0DKV0; -.
DR PRIDE; P0DKV0; -.
DR DNASU; 441452; -.
DR GeneID; 441452; -.
DR KEGG; hsa:441452; -.
DR CTD; 441452; -.
DR GeneCards; SPATA31C1; -.
DR HGNC; HGNC:27846; SPATA31C1.
DR neXtProt; NX_P0DKV0; -.
DR InParanoid; P0DKV0; -.
DR OrthoDB; 1095565at2759; -.
DR PathwayCommons; P0DKV0; -.
DR BioGRID-ORCS; 441452; 7 hits in 182 CRISPR screens.
DR GenomeRNAi; 441452; -.
DR Pharos; P0DKV0; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0DKV0; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR InterPro; IPR039509; SPATA31/FAM205.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 1.
PE 5: Uncertain;
KW Alternative splicing; Differentiation; Membrane; Reference proteome;
KW Spermatogenesis; Transmembrane; Transmembrane helix.
FT CHAIN 1..1188
FT /note="Putative spermatogenesis-associated protein 31C1"
FT /id="PRO_0000420908"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 57..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..239
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 683..688
FT /note="VSSLSL -> RPNFGV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044951"
FT VAR_SEQ 689..1188
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044952"
SQ SEQUENCE 1188 AA; 130522 MW; 3B59194E763C0E3B CRC64;
MENLPFPLKL LSASSLNTPS STPWVLDIFL TLVFALGLFF LLLPYFSYLR CDNPPSPSPR
KRKRHLVSQR HLVSQCPTGR RGRPRGRMKN HSLRACRECP RGLEETWDLL SQLQSLLGPH
LEKGDFGQLS GPDPPGEVGK RTPDGASRSS HEPMEDAAPI VSPLASPDPR TKHPQDLAST
PPPGPMTTSV SSLSASQPPE PSLLLERPSP EPPALFPHPP HTPDPLACSP PPPKGFTPPP
LRDSTLLTPS HCDSVALPLD TVPQSLSPRE DLAASVPAIS GLGGSNSQVS ALSWSQETTK
TWCIFNSSVQ QDHLSRQRDT TMSPLLFQAQ PLSHLGPESQ PFISSTPQFR PTPMAQAEAQ
AHLQSSFPVL SPAFLSPMKN TGVACPASQN KVQALSLPET QHPERPLLRK QLEGGLALPS
RVQKSQDVFS VSTPNLPQER LTSILPENFP VSPELWRQLE QYMGQRGRIQ ESLDLMQLQD
ELPGTSQAKG KPRPWQSSTS TGESSKEAQT VKFQLERDPC PHLGQILGET PQNLSRGMES
FPGKVLGATS EESERNLRKP LRSDSGSDLL RRTERNHIEN ILKAHMGRKL GQTNEGLIPV
SVRRSWLAVN QAFPVSNTHV KTSNLAAPKS RKACVNTAQV LSFLELCTQQ VLEAHIVRFW
AKHRWGLPLR VLKPIQCFQL EKVSSLSLIQ LAGPSSDTCE SGAGSKVEVA TLLGEPPMAS
LRKQVLTKPS VHMPERLQAS SPACKQFQRA PRGIPSSNDH GSLKAPTAGQ EGRWPSKPLT
YSLKGSTQQS RSLGAQSSRA GETREAVPQP TVPLGTCMRA NLQATSEDVR GFKAPGASKS
SLLPRMSVSQ DPRKLCLMEE AVSEFEPGMA TKSETQPQVS AAVVLLPDGQ ASVVPHASEN
LASQVPQGHL QSTPTGNMQA SQELCDLMSA RRSNMGHKEP RNPNCQGSCK SQSPMFPPTH
KRENSRKPNL EKHEEMFQGL RTPQLTPGRK TEDTRQNEGV QLLPSKKQPP SISHFGENIK
QFFETIFSKK ERKPAPVTAE SQKTVKNRSC VYGSSAEAER LMTAVGQIPE ENMSLCHARH
ASKVNQQRQQ FQAPVCGFPC NHRHPFYSDH SRMLSYAASS QQATLKNQSR PNRDRQIRDQ
QPLKSVRCNN EQWGLRHPQL LLPKKAVSPV SPPQHRPKTP SASSHHHH
