S31C2_HUMAN
ID S31C2_HUMAN Reviewed; 1134 AA.
AC B4DYI2;
DT 09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Putative spermatogenesis-associated protein 31C2;
DE AltName: Full=Protein FAM75C2;
GN Name=SPATA31C2; Synonyms=FAM75C2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AK302448; BAG63744.1; -; mRNA.
DR EMBL; AL353726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001159609.1; NM_001166137.1.
DR AlphaFoldDB; B4DYI2; -.
DR iPTMnet; B4DYI2; -.
DR PhosphoSitePlus; B4DYI2; -.
DR BioMuta; HGNC:24508; -.
DR EPD; B4DYI2; -.
DR MassIVE; B4DYI2; -.
DR PeptideAtlas; B4DYI2; -.
DR PRIDE; B4DYI2; -.
DR DNASU; 645961; -.
DR Ensembl; ENST00000675441.1; ENSP00000509164.1; ENSG00000177910.9.
DR GeneID; 645961; -.
DR KEGG; hsa:645961; -.
DR CTD; 645961; -.
DR GeneCards; SPATA31C2; -.
DR HGNC; HGNC:24508; SPATA31C2.
DR neXtProt; NX_B4DYI2; -.
DR GeneTree; ENSGT00950000183043; -.
DR OrthoDB; 1095565at2759; -.
DR PathwayCommons; B4DYI2; -.
DR BioGRID-ORCS; 645961; 9 hits in 181 CRISPR screens.
DR GenomeRNAi; 645961; -.
DR Pharos; B4DYI2; Tdark.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; B4DYI2; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR InterPro; IPR039509; SPATA31/FAM205.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 1.
PE 5: Uncertain;
KW Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1134
FT /note="Putative spermatogenesis-associated protein 31C2"
FT /id="PRO_0000420571"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 54..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..84
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..233
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..972
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1134 AA; 124429 MW; A9095F986A5D1175 CRC64;
MENLPFPLKL LSASSLNTPS STPWVLDIFL TLVFALGFFF LLLPYFSYLR CDNPPSPSPK
KRKRHLVSQR PAGRRGRPRG RMKNHSLRAC RECPRGLEET WDLLSQLQSL LGPHLEKGDF
GQLSGPDPPG EVGKRTPDGA SRSSHEPTED AAPIVSPLAS PDPRTKHPQD LASTPPPGPM
TTSVSSLSAS QPPEPSLLLE HPSPEPPALF PHPPRTPDPL ACSPPPPKGF TPPPLRDSTL
LTPSHCDSVA LPLDTVPQSL SPREDLAASV PGISGLGGSN SQVSALSWSQ ETTKTWCVFN
SSVQQDHLSR QRDTTMSPLL FQAQPLSHLE PESQPFISST PQFWPTPMAQ AEAQAHLQSS
FPVLSPAFLS PMKNTGVACP ASQNKVQALS LPETQHPERP LLKKQLEGGL ALPSRVQKSQ
DVFSVSTPNL PQERLTSILP ENFPVSPELW RQLEQHMGQR GRIQESLDLM QLQDELPGTS
QAKGKPRPWQ SSTSTGESSK EAQTVKFQLE RDPCPHLGQI LGETPQNLSR GMESFPGKVL
GATSEESERN LRKPLRSDSG SDLLRRTERN HIENILKAHM SRKLGQTNEG LIPVSVRRSW
LAVNQAFPVS NTHVKTSNLA APKSRKACVN TAQVLSFLEP CTQQVLGAHI VRFWAKHRWG
LPLRVLKPIQ CFQLEKVSSL SLIQLAGPSS DTCESGAGSK VEVATFLGEP PMASLRKQVL
TKPSVHMPER LQASSPACKQ FQRAPRGIPS SNDHGSLKAP TAGQEGRWPS KPLTYSLTGS
TQQSRSLGAQ SSRAGETREA VPQPTVPLGT CMRANLQATS EDVRGFKAPG ASKSSLLPRM
SVSQDPRKLC LMEEAVSEFE PGKATKSETQ PQVSATVVLL PDGQASVVPH ASENLASQVP
QGHLQSMPTG NMQASQELCD LMSARRSNMG HKEPRNPNCQ GSCKSQSPMF PPTHKRENSR
KPNLEKHEEM FQGLRTPQLT PGRKTEDTRQ NEGVQLLPSK KQPPSISHFG ENIKQFFQTI
FSKKERKPAP VTAESQKTVK NRSCVYGSSA EAERLMTAVG QILEENMSLC HARHASKVNQ
QRQQFQAPVC GFPCNHRHPF YSEHSRMLSY AASSQQATLK NQSRPNRDRQ IRDQ
