S31D1_HUMAN
ID S31D1_HUMAN Reviewed; 1576 AA.
AC Q6ZQQ2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Spermatogenesis-associated protein 31D1;
DE AltName: Full=Protein FAM75D1;
GN Name=SPATA31D1; Synonyms=FAM75D1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
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DR EMBL; AK128831; BAC87631.1; -; mRNA.
DR EMBL; CH471089; EAW62640.1; -; Genomic_DNA.
DR CCDS; CCDS47986.1; -.
DR RefSeq; NP_001001670.1; NM_001001670.2.
DR AlphaFoldDB; Q6ZQQ2; -.
DR IntAct; Q6ZQQ2; 2.
DR STRING; 9606.ENSP00000341988; -.
DR iPTMnet; Q6ZQQ2; -.
DR PhosphoSitePlus; Q6ZQQ2; -.
DR BioMuta; SPATA31D1; -.
DR DMDM; 74710945; -.
DR MassIVE; Q6ZQQ2; -.
DR PaxDb; Q6ZQQ2; -.
DR PeptideAtlas; Q6ZQQ2; -.
DR PRIDE; Q6ZQQ2; -.
DR ProteomicsDB; 68084; -.
DR Antibodypedia; 64398; 4 antibodies from 4 providers.
DR DNASU; 389763; -.
DR Ensembl; ENST00000344803.3; ENSP00000341988.2; ENSG00000214929.4.
DR GeneID; 389763; -.
DR KEGG; hsa:389763; -.
DR MANE-Select; ENST00000344803.3; ENSP00000341988.2; NM_001001670.3; NP_001001670.1.
DR UCSC; uc004amn.3; human.
DR CTD; 389763; -.
DR GeneCards; SPATA31D1; -.
DR HGNC; HGNC:37283; SPATA31D1.
DR HPA; ENSG00000214929; Tissue enriched (testis).
DR neXtProt; NX_Q6ZQQ2; -.
DR OpenTargets; ENSG00000214929; -.
DR VEuPathDB; HostDB:ENSG00000214929; -.
DR eggNOG; ENOG502SH7F; Eukaryota.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_005668_2_0_1; -.
DR InParanoid; Q6ZQQ2; -.
DR OMA; KHFQGGK; -.
DR OrthoDB; 76827at2759; -.
DR PhylomeDB; Q6ZQQ2; -.
DR TreeFam; TF338531; -.
DR PathwayCommons; Q6ZQQ2; -.
DR SignaLink; Q6ZQQ2; -.
DR BioGRID-ORCS; 389763; 7 hits in 1061 CRISPR screens.
DR GenomeRNAi; 389763; -.
DR Pharos; Q6ZQQ2; Tdark.
DR PRO; PR:Q6ZQQ2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6ZQQ2; protein.
DR Bgee; ENSG00000214929; Expressed in sperm and 17 other tissues.
DR Genevisible; Q6ZQQ2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR InterPro; IPR039509; SPATA31/FAM205.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 1.
PE 2: Evidence at transcript level;
KW Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1576
FT /note="Spermatogenesis-associated protein 31D1"
FT /id="PRO_0000332290"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 170..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..567
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1576 AA; 175618 MW; F76895284B4BA438 CRC64;
MENILCFLNS YTETGLSPDS HWLDIDPNFI CLSGLGLFIL YLFYVVLTLY SSPTEKNNDI
QKHQGRAKRR RKGGTFKGFP DWKSFQREEE EERKLLSLLK SFGPPVSCSP RGQHHDTNHF
RRLLCPDPVC RVCKRATADI QQLLSWESLK DAAPSVSPLA SSASATESSF TLASTPSATP
PEDLILSPRP KASPPPPLIL SPDLITTLAD LFSPSPLRDP LPPQPVSPLD SKFPIDHSPP
QQLPFPLLPP HHIERVESSL QPEASLSLNT IFSFGSTLCQ DISQAMNPID SCARHHGPPI
PSALPPEDCT VTQSKSSLTI LKTFPEMLSL GGSGGSSTSA PTIKGIDHSH LASSEFTWWQ
PHAKDSFSSN FVPSDFMEEL LTLHSSEAFL GGHSVANLIE PVNISFLSHD ILALLERQVK
KRGDFLMWKE NGKKPGSFPK QLRPNYQLNS SRNMLTSIAV KHDLAESFPF WASKGKLEWQ
HIHQQPPHSK CFEDHLEQKY VQLFWGLPSL HSESLHPTVL VQRGHSSMFV FFNGITNTSI
SHESPVLPPP QPLSLPSTQP LPLPQTLPQG QSPHLTQVKS LAQPQSPFRA LLPSPLFLIR
ICGVCFHRPQ NEARSLLPSE INHLEWNVLQ KVQESLWGLP SVVQKSQEDF CPPAPNPELV
RKSFKVHVPI SIIPGDFPLS SEVRKKLEQH IRRRLIQRRW GLPRRIHESL SLLRPQSKIS
ELSVSERIHG PLNISLVEGQ RCNVLKKSAS SFPRSFHERS SNMLSMENVG NYQGYSQETV
PKDHLLHGPE TSSDKDLRSN SERDLETHMM HLSGNDSGVR LGQKQLENAL TVRLSKKFEE
INEGRMPGTV HSSWHSVKQT MSLPEKSHSQ IKHRNLVTLV SEDHCVDTSQ EISFLSSNKQ
KMLEAHIKTF RMRMLWGLPL KVLESIEIFK SKADLSTSFS HFDLPSSATF ISQGDSKDGV
SKSRSRSTFQ GEKLGTTSSV PILDRPHPVS SPVVQEGQGT LRRQFSDTDH DLIETDSKDG
ASTSLRRGTT DFQSEKLDST SSFPILGHSY LVTSPVNQEK QGTLRREFSD TDNDLTESVR
TTEDGRQTFL PPPHSIVDEV SQKQTVLASR CSAELPIMQA GAGCESWDKR KSSFHNVDRL
QGSRKTFPVT NALQSQTRNN LTTSKSGSCS LTNVKASTSN ETEIFPPRIS VPQDPKSSYL
KNQMLSQLKL VQRKHSQPQS HFTDMSFALD NLSSKDLLTN SQGISSGDMG TSQVVHVHLE
DSGIRVAQKQ EPRVPTCVLQ KCQVTNFPPA VNRVSPVRPK GGELDGGDAG LGTSQRRRKS
LPVHNKTSGE VLGSKSSPTL KTQPPPENLF RKWMKTSLQW FNKPSISYEE QESSWEKGSS
LSSCVQNIGR VIRAAFTGTT EAQKIRKDTR EFLEEKLGHR HGIDITCPQE PLSFPVGLGK
AQHNPEVHVR AEPVQGCPCN YRAPSCKVTR TKSCSQQAIF VGQNYPTRIR QIIDKDRQPQ
KVEAFKGKIL CQSHPQSMPH RKPVPHPNPT CRRQVSLVCP AVPTSAKSPV FSDVPFLTGQ
KMLPKHLQGG KFPPTK
