S35A2_BOVIN
ID S35A2_BOVIN Reviewed; 393 AA.
AC Q58DA6;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=UDP-galactose translocator;
DE AltName: Full=Solute carrier family 35 member A2;
DE AltName: Full=UDP-galactose transporter;
DE Short=UDP-Gal-Tr;
DE Short=UGT;
GN Name=SLC35A2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- FUNCTION: Transports nucleotide sugars from the cytosol into Golgi
CC vesicles where glycosyltransferases function. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SLC35A3; the interaction is reduced in the
CC presence of SLC35A4 (By similarity). Found in a complex with SLC35A3
CC and SLC35A4 (By similarity). {ECO:0000250|UniProtKB:P78381}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:P78381}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; BT021691; AAX46538.1; -; mRNA.
DR AlphaFoldDB; Q58DA6; -.
DR SMR; Q58DA6; -.
DR STRING; 9913.ENSBTAP00000003591; -.
DR PaxDb; Q58DA6; -.
DR eggNOG; KOG2234; Eukaryota.
DR InParanoid; Q58DA6; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..393
FT /note="UDP-galactose translocator"
FT /id="PRO_0000239113"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 353..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 41180 MW; 4755228F2EBBC43E CRC64;
MAAVGSGGST ATAGPGAVSA GALEPGTSSA AHRRLKYISL AVLVVQNASL ILSIRYARTL
PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF LHEAVLVQYM DTLKLAVPSL
IYTLQNNLQY IAISNLPAAT FQVTYQLKIL TTALFSVLML NRSLSRLQWA SLLLLFTGVA
IVQAQQAGGG GPRPLDQNPG VGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL
FGTALGLVGL WWAEGTAVTH RGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA
TSLSIVLSTV ASIRLFGFHV DPLFALGAGL VIGAVYLYSL PRGAAKAIAS ASAPTSGPCT
HQQPPGQPPP PQLSSHHGDL STEPFLPKSV LVK
