S35A2_CANLF
ID S35A2_CANLF Reviewed; 397 AA.
AC Q8WMS0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=UDP-galactose translocator;
DE AltName: Full=Solute carrier family 35 member A2;
DE AltName: Full=UDP-galactose transporter;
DE Short=UDP-Gal-Tr;
DE Short=UGT;
GN Name=SLC35A2; Synonyms=UGT;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Olczak M., Guillen E., Hirschberg C.B.;
RT "Golgi ORF of UDP-galactose transporter from dog.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transports nucleotide sugars from the cytosol into Golgi
CC vesicles where glycosyltransferases function. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SLC35A3; the interaction is reduced in the
CC presence of SLC35A4 (By similarity). Found in a complex with SLC35A3
CC and SLC35A4 (By similarity). {ECO:0000250|UniProtKB:P78381}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:P78381}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; AY064406; AAL62489.2; -; mRNA.
DR RefSeq; NP_001003059.2; NM_001003059.2.
DR AlphaFoldDB; Q8WMS0; -.
DR SMR; Q8WMS0; -.
DR STRING; 9615.ENSCAFP00000060247; -.
DR PaxDb; Q8WMS0; -.
DR GeneID; 403595; -.
DR KEGG; cfa:403595; -.
DR CTD; 7355; -.
DR eggNOG; KOG2234; Eukaryota.
DR InParanoid; Q8WMS0; -.
DR OrthoDB; 703674at2759; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..397
FT /note="UDP-galactose translocator"
FT /id="PRO_0000289574"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 397 AA; 41468 MW; 02261B026E907429 CRC64;
MAAVGSGGSN AAAGPGAVSA GSLEPGTASA AHRRLKYISL AVLVVQNASL ILSIRYARTL
PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLALF LHEAVLVQYV DTLKLAVPSL
IYTLQNNLQY VAISNMPAAT FQVTYQLKIL TTALFSVLML NRSLSRLQWA SLLLLFTGVA
IVQAQQAGGG GPRPLDQNPG AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL
FGTALGLVGL WWAEGTAVAR RGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA
TSLSIVLSTV ASIRLFGFHV DPLFALGAGL VIGAVYLYSL PRGTAKAIAS TSASASASTS
GPCTHQQPPG QPPPPKLSSH RADLSTEPFL PKSVLVK
