S35A2_MOUSE
ID S35A2_MOUSE Reviewed; 390 AA.
AC Q9R0M8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=UDP-galactose translocator;
DE AltName: Full=Solute carrier family 35 member A2;
DE AltName: Full=UDP-galactose transporter;
DE Short=UDP-Gal-Tr;
DE Short=UGT;
DE Short=mUGT1;
GN Name=Slc35a2; Synonyms=Ugt1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=10578063; DOI=10.1093/oxfordjournals.jbchem.a022556;
RA Ishida N., Yoshioka S., Iida M., Sudo K., Miura N., Aoki K., Kawakita M.;
RT "Indispensability of transmembrane domains of Golgi UDP-galactose
RT transporter as revealed by analysis of genetic defects in UDP-galactose
RT transporter-deficient murine had-1 mutant cell lines and construction of
RT deletion mutants.";
RL J. Biochem. 126:1107-1117(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Transports nucleotide sugars from the cytosol into Golgi
CC vesicles where glycosyltransferases function.
CC -!- SUBUNIT: Interacts with SLC35A3; the interaction is reduced in the
CC presence of SLC35A4 (By similarity). Found in a complex with SLC35A3
CC and SLC35A4 (By similarity). {ECO:0000250|UniProtKB:P78381}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:P78381}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; AB027147; BAA86885.1; -; mRNA.
DR EMBL; BC037701; AAH37701.1; -; mRNA.
DR CCDS; CCDS52987.1; -.
DR PIR; JC7162; JC7162.
DR RefSeq; NP_001077406.1; NM_001083937.1.
DR AlphaFoldDB; Q9R0M8; -.
DR SMR; Q9R0M8; -.
DR STRING; 10090.ENSMUSP00000111327; -.
DR TCDB; 2.A.7.12.8; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q9R0M8; -.
DR PhosphoSitePlus; Q9R0M8; -.
DR SwissPalm; Q9R0M8; -.
DR MaxQB; Q9R0M8; -.
DR PaxDb; Q9R0M8; -.
DR PRIDE; Q9R0M8; -.
DR ProteomicsDB; 256879; -.
DR Antibodypedia; 25927; 65 antibodies from 16 providers.
DR DNASU; 22232; -.
DR Ensembl; ENSMUST00000115660; ENSMUSP00000111324; ENSMUSG00000031156.
DR Ensembl; ENSMUST00000155967; ENSMUSP00000146730; ENSMUSG00000031156.
DR GeneID; 22232; -.
DR KEGG; mmu:22232; -.
DR UCSC; uc009sna.1; mouse.
DR CTD; 7355; -.
DR MGI; MGI:1345297; Slc35a2.
DR VEuPathDB; HostDB:ENSMUSG00000031156; -.
DR eggNOG; KOG2234; Eukaryota.
DR GeneTree; ENSGT00950000182827; -.
DR InParanoid; Q9R0M8; -.
DR Reactome; R-MMU-727802; Transport of nucleotide sugars.
DR BioGRID-ORCS; 22232; 19 hits in 74 CRISPR screens.
DR ChiTaRS; Slc35a2; mouse.
DR PRO; PR:Q9R0M8; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9R0M8; protein.
DR Bgee; ENSMUSG00000031156; Expressed in left colon and 250 other tissues.
DR ExpressionAtlas; Q9R0M8; baseline and differential.
DR Genevisible; Q9R0M8; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IDA:MGI.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IDA:MGI.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0072334; P:UDP-galactose transmembrane transport; IDA:MGI.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..390
FT /note="UDP-galactose translocator"
FT /id="PRO_0000213354"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 40766 MW; F7CD57C5C0D401B8 CRC64;
MAAVGVGGST AAAGAGAVSS GALEPGSTTA AHRRLKYISL AVLVVQNASL ILSIRYARTL
PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF LHEAVLVQYV DTLKLAVPSL
IYTLQNNLQY VAISNLPAAT FQVTYQLKIL TTALFSVLML NRSLSRLQWA SLLLLFTGVA
IVQAQQAGGS GPRPLDQNPG AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL
FGTALGLVGL WWAEGTAVAS QGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA
TSLSIVLSTV ASIRLFGFHL DPLFALGAGL VIGAVYLYSL PRGAVKAIAS ASASGPCIHQ
QPPGQPPPPQ LSSRGDLTTE PFLPKSVLVK
