ID   S35A3_BOVIN             Reviewed;         326 AA.
AC   Q6YC49; A7Z022;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=UDP-N-acetylglucosamine transporter;
DE   AltName: Full=Golgi UDP-GlcNAc transporter;
DE   AltName: Full=Solute carrier family 35 member A3;
GN   Name=SLC35A3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISEASE.
RX   PubMed=16344554; DOI=10.1101/gr.3690506;
RA   Thomsen B., Horn P., Panitz F., Bendixen E., Petersen A.H., Holm L.E.,
RA   Nielsen V.H., Agerholm J.S., Arnbjerg J., Bendixen C.;
RT   "A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-
RT   acetylglucosamine transporter, causes complex vertebral malformation.";
RL   Genome Res. 16:97-105(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc)
CC       transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate
CC       for Golgi-resident glycosyltransferases that generate branching of
CC       diantennary oligosaccharides (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y2D2}.
CC   -!- SUBUNIT: Interacts with SLC35A2; the interaction is reduced in the
CC       presence of SLC35A4 (By similarity). Found in a complex with SLC35A2
CC       and SLC35A4 (By similarity). {ECO:0000250|UniProtKB:Q9Y2D2}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9Y2D2}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DISEASE: Note=Defects in SLC35A3 may be cause of complex vertebral
CC       malformation (CVM) in Holstein. {ECO:0000269|PubMed:16344554}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AY160683; AAO22138.1; -; Genomic_DNA.
DR   EMBL; BC153220; AAI53221.1; -; mRNA.
DR   RefSeq; NP_001098856.1; NM_001105386.1.
DR   RefSeq; XP_005204177.1; XM_005204120.2.
DR   RefSeq; XP_015319233.1; XM_015463747.1.
DR   AlphaFoldDB; Q6YC49; -.
DR   SMR; Q6YC49; -.
DR   STRING; 9913.ENSBTAP00000016519; -.
DR   PaxDb; Q6YC49; -.
DR   PRIDE; Q6YC49; -.
DR   Ensembl; ENSBTAT00000016519; ENSBTAP00000016519; ENSBTAG00000012454.
DR   Ensembl; ENSBTAT00000076918; ENSBTAP00000063794; ENSBTAG00000012454.
DR   GeneID; 520918; -.
DR   KEGG; bta:520918; -.
DR   CTD; 23443; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012454; -.
DR   VGNC; VGNC:49969; SLC35A3.
DR   eggNOG; KOG2234; Eukaryota.
DR   GeneTree; ENSGT00950000182827; -.
DR   HOGENOM; CLU_024645_1_0_1; -.
DR   InParanoid; Q6YC49; -.
DR   OMA; AFFSVTM; -.
DR   OrthoDB; 703674at2759; -.
DR   TreeFam; TF315345; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000012454; Expressed in spiral colon and 109 other tissues.
DR   ExpressionAtlas; Q6YC49; baseline and differential.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:1990569; P:UDP-N-acetylglucosamine transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR007271; Nuc_sug_transpt.
DR   PANTHER; PTHR10231; PTHR10231; 1.
DR   Pfam; PF04142; Nuc_sug_transp; 1.
DR   PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..326
FT                   /note="UDP-N-acetylglucosamine transporter"
FT                   /id="PRO_0000213355"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   326 AA;  36067 MW;  31F34B10BFB3DC37 CRC64;
     MSANLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAELLK IMACILLVYK
     DSKCSLRALN RILHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK
     ILTTALFSVS MLSKKLGVYQ WLSLVILMTG VAFVQWPSDS QELNSKELSA GSQFVGLMAV
     LTACFSSGFA GVYFEKILKE TKQSVWIRNI QLGFFGSIFG LMGVYVYDGE LVSKNGFFQG
     YNRLTWIVVV LQALGGLVIA AVIKYADNIL KGFATSLSII LSTLISYFWL QDFVPTSVFF
     LGAILVITAT FLYGYDPKPA GNPTKA