ID   S35A3_CANLF             Reviewed;         326 AA.
AC   O77592;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=UDP-N-acetylglucosamine transporter;
DE   AltName: Full=Golgi UDP-GlcNAc transporter;
DE   AltName: Full=Solute carrier family 35 member A3;
GN   Name=SLC35A3;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9653110; DOI=10.1073/pnas.95.14.7888;
RA   Guillen E., Abeijon C., Hirschberg C.B.;
RT   "Mammalian Golgi apparatus UDP-N-acetylglucosamine transporter: molecular
RT   cloning by phenotypic correction of a yeast mutant.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:7888-7892(1998).
CC   -!- FUNCTION: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc)
CC       transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate
CC       for Golgi-resident glycosyltransferases that generate branching of
CC       diantennary oligosaccharides (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y2D2}.
CC   -!- SUBUNIT: Interacts with SLC35A2; the interaction is reduced in the
CC       presence of SLC35A4 (By similarity). Found in a complex with SLC35A2
CC       and SLC35A4 (By similarity). {ECO:0000250|UniProtKB:Q9Y2D2}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9Y2D2}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF057365; AAC39260.1; -; mRNA.
DR   RefSeq; NP_001003385.1; NM_001003385.1.
DR   AlphaFoldDB; O77592; -.
DR   SMR; O77592; -.
DR   STRING; 9612.ENSCAFP00000029677; -.
DR   PaxDb; O77592; -.
DR   Ensembl; ENSCAFT00030030636; ENSCAFP00030026721; ENSCAFG00030016487.
DR   Ensembl; ENSCAFT00845024146; ENSCAFP00845018964; ENSCAFG00845013522.
DR   GeneID; 442991; -.
DR   KEGG; cfa:442991; -.
DR   CTD; 23443; -.
DR   VEuPathDB; HostDB:ENSCAFG00845013522; -.
DR   eggNOG; KOG2234; Eukaryota.
DR   GeneTree; ENSGT00950000182827; -.
DR   HOGENOM; CLU_024645_1_0_1; -.
DR   InParanoid; O77592; -.
DR   OrthoDB; 703674at2759; -.
DR   Reactome; R-CFA-727802; Transport of nucleotide sugars.
DR   Proteomes; UP000002254; Chromosome 6.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:CACAO.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:1990569; P:UDP-N-acetylglucosamine transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR007271; Nuc_sug_transpt.
DR   PANTHER; PTHR10231; PTHR10231; 1.
DR   Pfam; PF04142; Nuc_sug_transp; 1.
DR   PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..326
FT                   /note="UDP-N-acetylglucosamine transporter"
FT                   /id="PRO_0000213356"
FT   TRANSMEM        8..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   326 AA;  36156 MW;  1F18B52B3EBEB77D CRC64;
     MSTNLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAELLK IMACILLVYK
     DSKCSLRALN RILHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK
     ILTTALFSVS MLSKKLGVYQ WLSLVILMTG VAFVQWPSDS QELDSKELSA GSQFVGLMAV
     LTACFSSGFA GVYFEKILKE TKQSVWIRNI QLGFFGSIFG LMGVYIYDGE LVSKNGFFQG
     YNRLTWIVVI LQALGGLVIA AVIKYADNIL KGFATSLSII LSTLISYFWL QDFVPTSVFF
     LGAILVITAT FLYGYDPKPT GNPTKA