ID   S35A3_RAT               Reviewed;         326 AA.
AC   Q6AXR5;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=UDP-N-acetylglucosamine transporter;
DE   AltName: Full=Golgi UDP-GlcNAc transporter;
DE   AltName: Full=Solute carrier family 35 member A3;
GN   Name=Slc35a3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc)
CC       transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate
CC       for Golgi-resident glycosyltransferases that generate branching of
CC       diantennary oligosaccharides (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y2D2}.
CC   -!- SUBUNIT: Interacts with SLC35A2; the interaction is reduced in the
CC       presence of SLC35A4 (By similarity). Found in a complex with SLC35A2
CC       and SLC35A4 (By similarity). {ECO:0000250|UniProtKB:Q9Y2D2}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9Y2D2}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC079371; AAH79371.1; -; mRNA.
DR   RefSeq; NP_001012082.1; NM_001012082.1.
DR   AlphaFoldDB; Q6AXR5; -.
DR   SMR; Q6AXR5; -.
DR   STRING; 10116.ENSRNOP00000021676; -.
DR   PRIDE; Q6AXR5; -.
DR   Ensembl; ENSRNOT00000085122; ENSRNOP00000074264; ENSRNOG00000015502.
DR   GeneID; 310808; -.
DR   KEGG; rno:310808; -.
DR   UCSC; RGD:1308615; rat.
DR   CTD; 23443; -.
DR   RGD; 1308615; Slc35a3.
DR   eggNOG; KOG2234; Eukaryota.
DR   GeneTree; ENSGT00940000157395; -.
DR   HOGENOM; CLU_024645_1_0_1; -.
DR   InParanoid; Q6AXR5; -.
DR   OMA; AFFSVTM; -.
DR   OrthoDB; 703674at2759; -.
DR   PhylomeDB; Q6AXR5; -.
DR   TreeFam; TF315345; -.
DR   Reactome; R-RNO-727802; Transport of nucleotide sugars.
DR   PRO; PR:Q6AXR5; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000061832; Expressed in stomach and 18 other tissues.
DR   Genevisible; Q6AXR5; RN.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:1990569; P:UDP-N-acetylglucosamine transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR007271; Nuc_sug_transpt.
DR   PANTHER; PTHR10231; PTHR10231; 1.
DR   Pfam; PF04142; Nuc_sug_transp; 1.
DR   PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..326
FT                   /note="UDP-N-acetylglucosamine transporter"
FT                   /id="PRO_0000213359"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   326 AA;  36079 MW;  4C1BB88723E59C24 CRC64;
     MSANLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAEFLK IMACIFLVYK
     DSKCSVRTLN RVLHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK
     ILTTALFSVS MLGKKLGMYQ WLSLVILMAG VAFVQWPSDS QELNSKDLST GSQFVGLMAV
     LIACFSSGFA GVYFEKILKE TKQSVWIRNI QLGFFGSIFG LMGVYVYDGE LVSKNGFFQG
     YNQLTWIVVV LQALGGLVIA AVIKYADNIL KGFATSLSII LSTIISYFWL QDFVPTSVFF
     LGAILVIAAT FLYGYDPKPA GNPTKA