ID   S35A4_BOVIN             Reviewed;         324 AA.
AC   Q05B73;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Probable UDP-sugar transporter protein SLC35A4 {ECO:0000305};
DE   AltName: Full=Solute carrier family 35 member A4 {ECO:0000250|UniProtKB:Q96G79};
GN   Name=SLC35A4 {ECO:0000250|UniProtKB:Q96G79};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon, Fetal muscle, and Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the transport of CDP-ribitol (By similarity). Does
CC       not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine
CC       transport activity (By similarity). {ECO:0000250|UniProtKB:Q96G79}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out);
CC         Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069;
CC         Evidence={ECO:0000250|UniProtKB:Q96G79};
CC   -!- SUBUNIT: Found in a complex with SLC35A2 and SLC35A3.
CC       {ECO:0000250|UniProtKB:Q96G79}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q91ZR7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC122672; AAI22673.1; -; mRNA.
DR   EMBL; BC150113; AAI50114.1; -; mRNA.
DR   EMBL; BC151579; AAI51580.1; -; mRNA.
DR   RefSeq; NP_001073080.1; NM_001079612.1.
DR   RefSeq; XP_005209526.1; XM_005209469.2.
DR   AlphaFoldDB; Q05B73; -.
DR   SMR; Q05B73; -.
DR   PaxDb; Q05B73; -.
DR   PRIDE; Q05B73; -.
DR   GeneID; 539354; -.
DR   KEGG; bta:539354; -.
DR   CTD; 113829; -.
DR   eggNOG; KOG2234; Eukaryota.
DR   HOGENOM; CLU_024645_5_1_1; -.
DR   InParanoid; Q05B73; -.
DR   OrthoDB; 754910at2759; -.
DR   TreeFam; TF315345; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007271; Nuc_sug_transpt.
DR   PANTHER; PTHR10231; PTHR10231; 1.
DR   Pfam; PF04142; Nuc_sug_transp; 1.
DR   PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..324
FT                   /note="Probable UDP-sugar transporter protein SLC35A4"
FT                   /id="PRO_0000337747"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..52
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..141
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..180
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..214
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        236..248
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        249..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        272..275
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        276..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..324
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
SQ   SEQUENCE   324 AA;  34540 MW;  DA1F51489C8F245E CRC64;
     MSVEDGGVPG LGRPRKARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP SSAVLLTELT
     KLLLCALSLL VGWQAWPQGT PPWRQAAPFA LSALLYGANN NLVIYLQRYM DPSTYQVLSN
     LKIGSTALFY CLCLRHRLSA RQGLALLLLM AAGACYAAGG LQDPGTTLPG PPSAAATSPM
     PLHITPLGLL LLILYCLISG LSSVYTELLM KRQRLPLALQ NLFLYSFGVL LNLGLHAGGG
     PGPGLLEGFS GWMALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAALLRL
     QLTAAFFLAT LLIGLAVRLY YGSR