ID   S35A4_DANRE             Reviewed;         314 AA.
AC   A0JMG9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Probable UDP-sugar transporter protein SLC35A4 {ECO:0000305};
DE   AltName: Full=Solute carrier family 35 member A4 {ECO:0000250|UniProtKB:Q96G79};
GN   Name=slc35a4 {ECO:0000250|UniProtKB:Q96G79};
GN   ORFNames=zgc:153507 {ECO:0000312|EMBL:AAI25876.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the transport of CDP-ribitol (By similarity). Does
CC       not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine
CC       transport activity (By similarity). {ECO:0000250|UniProtKB:Q96G79}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out);
CC         Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069;
CC         Evidence={ECO:0000250|UniProtKB:Q96G79};
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q91ZR7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC125875; AAI25876.1; -; mRNA.
DR   AlphaFoldDB; A0JMG9; -.
DR   SMR; A0JMG9; -.
DR   STRING; 7955.ENSDARP00000084629; -.
DR   PaxDb; A0JMG9; -.
DR   ZFIN; ZDB-GENE-061103-595; slc35a4.
DR   eggNOG; KOG2234; Eukaryota.
DR   InParanoid; A0JMG9; -.
DR   PhylomeDB; A0JMG9; -.
DR   PRO; PR:A0JMG9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007271; Nuc_sug_transpt.
DR   PANTHER; PTHR10231; PTHR10231; 1.
DR   Pfam; PF04142; Nuc_sug_transp; 1.
DR   PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..314
FT                   /note="Probable UDP-sugar transporter protein SLC35A4"
FT                   /id="PRO_0000337754"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..54
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..88
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..145
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..175
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..206
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        228..242
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        264..267
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        268..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
SQ   SEQUENCE   314 AA;  34293 MW;  EF4B6820C0368A6C CRC64;
     MIAISADESP ESSSPALRLR WLFLLLLLVL IYGSHAPLLS LCKTQAQIPF SASSCVLLIE
     TSKLFISFAS LLASGSVSTL RISISMTTAS PYAVPAVLYA FNNHLVVFMQ AYMDPSSFQV
     LSNLKIASTA LLYTSCLGKR LHRRQWFAMG LLVSAGVSHS CFSYDLEGKR ETAVYITSWG
     LLLVLVYCFV SGLAAVYTER VLKSQRLPLS MQNLFLYTFG VVVNLASHLS GGEQKGFFEG
     YSAVVWVIVA GQVANGLLMS VVMKHGTGIT RLFVISSAML VNAVLSWGIL GVQLTGYFLF
     PVVLIGWAVY LYYT