S35A4_PIG
ID S35A4_PIG Reviewed; 324 AA.
AC Q8MIA3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Probable UDP-sugar transporter protein SLC35A4 {ECO:0000305};
DE AltName: Full=Nucleotide sugar transporter {ECO:0000303|PubMed:12770764};
DE AltName: Full=Solute carrier family 35 member A4 {ECO:0000250|UniProtKB:Q96G79};
GN Name=SLC35A4 {ECO:0000250|UniProtKB:Q96G79};
GN Synonyms=NST {ECO:0000303|PubMed:12770764};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12770764; DOI=10.1016/s0300-9084(03)00046-4;
RA Martinez-Duncker I., Mollicone R., Codogno P., Oriol R.;
RT "The nucleotide-sugar transporter family: a phylogenetic approach.";
RL Biochimie 85:245-260(2003).
CC -!- FUNCTION: Mediates the transport of CDP-ribitol (By similarity). Does
CC not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine
CC transport activity (By similarity). {ECO:0000250|UniProtKB:Q96G79}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out);
CC Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069;
CC Evidence={ECO:0000250|UniProtKB:Q96G79};
CC -!- SUBUNIT: Found in a complex with SLC35A2 and SLC35A3.
CC {ECO:0000250|UniProtKB:Q96G79}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q91ZR7}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; AJ489473; CAD33795.1; -; mRNA.
DR RefSeq; NP_999116.1; NM_213951.1.
DR RefSeq; XP_005661784.1; XM_005661727.2.
DR RefSeq; XP_013850654.1; XM_013995200.1.
DR RefSeq; XP_013850655.1; XM_013995201.1.
DR RefSeq; XP_013850656.1; XM_013995202.1.
DR AlphaFoldDB; Q8MIA3; -.
DR SMR; Q8MIA3; -.
DR STRING; 9823.ENSSSCP00000015284; -.
DR PaxDb; Q8MIA3; -.
DR PRIDE; Q8MIA3; -.
DR Ensembl; ENSSSCT00000015697; ENSSSCP00000015284; ENSSSCG00000014367.
DR Ensembl; ENSSSCT00000070371; ENSSSCP00000070453; ENSSSCG00000014367.
DR Ensembl; ENSSSCT00015007439; ENSSSCP00015002975; ENSSSCG00015005601.
DR Ensembl; ENSSSCT00015007447; ENSSSCP00015002978; ENSSSCG00015005601.
DR Ensembl; ENSSSCT00025070453; ENSSSCP00025030421; ENSSSCG00025051557.
DR Ensembl; ENSSSCT00025070523; ENSSSCP00025030452; ENSSSCG00025051557.
DR Ensembl; ENSSSCT00030043863; ENSSSCP00030019806; ENSSSCG00030031676.
DR Ensembl; ENSSSCT00035105570; ENSSSCP00035045362; ENSSSCG00035077499.
DR Ensembl; ENSSSCT00035105604; ENSSSCP00035045382; ENSSSCG00035077499.
DR Ensembl; ENSSSCT00040089884; ENSSSCP00040039506; ENSSSCG00040065848.
DR Ensembl; ENSSSCT00040089957; ENSSSCP00040039538; ENSSSCG00040065848.
DR Ensembl; ENSSSCT00045027798; ENSSSCP00045019228; ENSSSCG00045016352.
DR Ensembl; ENSSSCT00050107635; ENSSSCP00050047630; ENSSSCG00050078140.
DR Ensembl; ENSSSCT00050107658; ENSSSCP00050047642; ENSSSCG00050078140.
DR Ensembl; ENSSSCT00055006005; ENSSSCP00055004701; ENSSSCG00055003112.
DR Ensembl; ENSSSCT00060053433; ENSSSCP00060022764; ENSSSCG00060039495.
DR Ensembl; ENSSSCT00060053438; ENSSSCP00060022767; ENSSSCG00060039495.
DR Ensembl; ENSSSCT00065066624; ENSSSCP00065028891; ENSSSCG00065048701.
DR GeneID; 396994; -.
DR KEGG; ssc:396994; -.
DR CTD; 113829; -.
DR VGNC; VGNC:93069; SLC35A4.
DR eggNOG; KOG2234; Eukaryota.
DR GeneTree; ENSGT00950000182827; -.
DR HOGENOM; CLU_024645_5_1_1; -.
DR InParanoid; Q8MIA3; -.
DR OMA; SSCVVMI; -.
DR OrthoDB; 754910at2759; -.
DR TreeFam; TF315345; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000014367; Expressed in testis and 41 other tissues.
DR Genevisible; Q8MIA3; SS.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..324
FT /note="Probable UDP-sugar transporter protein SLC35A4"
FT /id="PRO_0000337750"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..52
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..140
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..177
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..214
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 249..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..279
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
SQ SEQUENCE 324 AA; 34225 MW; B0A5C45ECBAC76E1 CRC64;
MSVEDGGLPG LGGPGQARWT LMLLLSTATY GAHAPLLALC HVDGRVPFRP SSAVLLTELT
KLLLCALSLL VGWQAWPPRT PPWRQAAPFA LSALLYGANN NLVIHLQHYM DPSTYQVLSN
LKIGSTALFY CLCLRRRLSA RQGLALLLLM AAGACYAAGG LRDPGSPLPE SPSTAASGPV
PLHVTAPGLL LLLLYCLISG LSSVYTELLL KRQRLPLALQ NLFLYTFGVL LNLGLHAGGG
PGPGLLEGFS GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAALLRL
QLTAAFFLAA LLIGLAVHLY YGSR
