S35A4_PONAB
ID S35A4_PONAB Reviewed; 324 AA.
AC Q5RA79;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Probable UDP-sugar transporter protein SLC35A4 {ECO:0000305};
DE AltName: Full=Solute carrier family 35 member A4 {ECO:0000250|UniProtKB:Q96G79};
GN Name=SLC35A4 {ECO:0000250|UniProtKB:Q96G79};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the transport of CDP-ribitol (By similarity). Does
CC not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine
CC transport activity (By similarity). {ECO:0000250|UniProtKB:Q96G79}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out);
CC Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069;
CC Evidence={ECO:0000250|UniProtKB:Q96G79};
CC -!- SUBUNIT: Found in a complex with SLC35A2 and SLC35A3.
CC {ECO:0000250|UniProtKB:Q96G79}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q91ZR7}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; CR859140; CAH91331.1; -; mRNA.
DR RefSeq; NP_001125786.1; NM_001132314.2.
DR AlphaFoldDB; Q5RA79; -.
DR SMR; Q5RA79; -.
DR STRING; 9601.ENSPPYP00000017731; -.
DR GeneID; 100172714; -.
DR KEGG; pon:100172714; -.
DR CTD; 113829; -.
DR eggNOG; KOG2234; Eukaryota.
DR HOGENOM; CLU_024645_5_1_1; -.
DR InParanoid; Q5RA79; -.
DR OMA; SSCVVMI; -.
DR OrthoDB; 754910at2759; -.
DR TreeFam; TF315345; -.
DR Proteomes; UP000001595; Chromosome 5.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..324
FT /note="Probable UDP-sugar transporter protein SLC35A4"
FT /id="PRO_0000337751"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..52
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..142
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..180
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..214
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..275
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 276..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
SQ SEQUENCE 324 AA; 34676 MW; 4EE36F09AA44C2A8 CRC64;
MSVEDGGMPG LSRPRQARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP SSAVLLTELT
KLLLCAFSLL VGWQAWPQGA PPWRQAAPFA LSALLYGANN NLVIYLQRYM DPSTYQVLSN
LKIGSTAVLY CLCLRHRLSV RQGLALLLLM AAGACYAAGG LQVPGNTLPR PPPAAAASPM
PLHITPLGLL LLILYCLISG LSSVYTELLM KRQQLPLALQ NLFLYTFGVL LNLGLHAGGG
PGPGLLEGFS GWAALVVLSQ ALNGLLMSVV MKHGSSITRL FVVSCSLVVN AVLSAVLLRL
QLTAAFFLAT LLIGLAMRLY YGSR
