S35A4_RAT
ID S35A4_RAT Reviewed; 324 AA.
AC Q91ZR7; Q5RKL6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Probable UDP-sugar transporter protein SLC35A4 {ECO:0000305};
DE AltName: Full=Complex leucine repeat protein {ECO:0000303|PubMed:12124754};
DE AltName: Full=Solute carrier family 35 member A4 {ECO:0000312|RGD:628792};
GN Name=Slc35a4 {ECO:0000312|RGD:628792};
GN Synonyms=Clrp {ECO:0000303|PubMed:12124754};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=12124754; DOI=10.1002/neu.10076;
RA Perez-Marquez J., Reguillo B., Paniagua R.;
RT "Cloning of the cDNA and mRNA expression of CLRP, a complex leucine repeat
RT protein of the Golgi apparatus expressed by specific neurons of the rat
RT brain.";
RL J. Neurobiol. 52:166-173(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates the transport of CDP-ribitol (By similarity). Does
CC not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine
CC transport activity (By similarity). {ECO:0000250|UniProtKB:Q96G79}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out);
CC Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069;
CC Evidence={ECO:0000250|UniProtKB:Q96G79};
CC -!- SUBUNIT: Found in a complex with SLC35A2 and SLC35A3.
CC {ECO:0000250|UniProtKB:Q96G79}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:12124754}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in the kidney, lung, testis, and
CC prostate. Expressed in the brain by sets of neurons, such as the
CC pyramidal cells of the cortex, the Purkinje cells of the cerebellum,
CC and the motoneurons of the brainstem. {ECO:0000269|PubMed:12124754}.
CC -!- DEVELOPMENTAL STAGE: Expressed at E15. Expression is maintained until
CC postnatal day 10 and decreases in adults.
CC {ECO:0000269|PubMed:12124754}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; AF406814; AAK96221.1; -; mRNA.
DR EMBL; BC085695; AAH85695.1; -; mRNA.
DR EMBL; BC086986; AAH86986.1; -; mRNA.
DR RefSeq; NP_671481.2; NM_147140.2.
DR RefSeq; XP_006254590.1; XM_006254528.2.
DR RefSeq; XP_006254591.1; XM_006254529.3.
DR RefSeq; XP_008770241.1; XM_008772019.2.
DR AlphaFoldDB; Q91ZR7; -.
DR SMR; Q91ZR7; -.
DR STRING; 10116.ENSRNOP00000003878; -.
DR PaxDb; Q91ZR7; -.
DR PRIDE; Q91ZR7; -.
DR Ensembl; ENSRNOT00000003878; ENSRNOP00000003878; ENSRNOG00000002908.
DR Ensembl; ENSRNOT00000100525; ENSRNOP00000096880; ENSRNOG00000002908.
DR Ensembl; ENSRNOT00000109501; ENSRNOP00000079324; ENSRNOG00000002908.
DR GeneID; 257647; -.
DR KEGG; rno:257647; -.
DR UCSC; RGD:628792; rat.
DR CTD; 113829; -.
DR RGD; 628792; Slc35a4.
DR eggNOG; KOG2234; Eukaryota.
DR GeneTree; ENSGT00950000182827; -.
DR HOGENOM; CLU_024645_5_1_1; -.
DR InParanoid; Q91ZR7; -.
DR OMA; SSCVVMI; -.
DR OrthoDB; 754910at2759; -.
DR PhylomeDB; Q91ZR7; -.
DR TreeFam; TF315345; -.
DR PRO; PR:Q91ZR7; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000002908; Expressed in skeletal muscle tissue and 19 other tissues.
DR Genevisible; Q91ZR7; RN.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0032056; P:positive regulation of translation in response to stress; ISO:RGD.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..324
FT /note="Probable UDP-sugar transporter protein SLC35A4"
FT /id="PRO_0000337752"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..52
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..142
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..180
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..214
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 249..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..279
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96G79"
FT CONFLICT 130
FT /note="Y -> C (in Ref. 1; AAK96221)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="R -> C (in Ref. 1; AAK96221)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="Q -> H (in Ref. 1; AAK96221)"
FT /evidence="ECO:0000305"
FT CONFLICT 275
FT /note="S -> I (in Ref. 1; AAK96221)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 324 AA; 34705 MW; F66D814CD7CB77C6 CRC64;
MSVEDGGMPG LARPKQARWT LMLFLSTAMY GAHAPFLALC HVDGRVPFRP SSAVLLTELT
KLLLCAFSLL VGWQTWPQGT PPWRQAAPFA LSALLYGANN NLVIYLQRYM DPSTYQVLSN
LKIGSTALLY CLCLGHRLSA RQGLALLLLM AAGACYASGG FQEPGNTLPG PRSAAGARPM
PLHITPLGLL LLILYCLISG LSSVYTELIM KRQRLPLALQ NLFLYTFGVI LNLGLYAGSG
PGPGFLEGFS GWAVLVVLNQ AVNGLLMSAV MKHGSSITRL FIVSCSLVVN AVLSAVLLQL
QLTATFFLAA LLIGLAVCLY YGSP
