ID   S35A4_XENTR             Reviewed;         321 AA.
AC   A4IHW3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Probable UDP-sugar transporter protein SLC35A4 {ECO:0000305};
DE   AltName: Full=Solute carrier family 35 member A4 {ECO:0000250|UniProtKB:Q96G79};
GN   Name=slc35a4 {ECO:0000250|UniProtKB:Q96G79};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the transport of CDP-ribitol (By similarity). Does
CC       not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine
CC       transport activity (By similarity). {ECO:0000250|UniProtKB:Q96G79}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out);
CC         Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069;
CC         Evidence={ECO:0000250|UniProtKB:Q96G79};
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q91ZR7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC135720; AAI35721.1; -; mRNA.
DR   RefSeq; NP_001096322.1; NM_001102852.1.
DR   AlphaFoldDB; A4IHW3; -.
DR   SMR; A4IHW3; -.
DR   STRING; 8364.ENSXETP00000054304; -.
DR   PaxDb; A4IHW3; -.
DR   DNASU; 100124906; -.
DR   GeneID; 100124906; -.
DR   KEGG; xtr:100124906; -.
DR   CTD; 113829; -.
DR   Xenbase; XB-GENE-958297; slc35a4.
DR   eggNOG; KOG2234; Eukaryota.
DR   InParanoid; A4IHW3; -.
DR   OrthoDB; 754910at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007271; Nuc_sug_transpt.
DR   PANTHER; PTHR10231; PTHR10231; 1.
DR   Pfam; PF04142; Nuc_sug_transp; 1.
DR   PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..321
FT                   /note="Probable UDP-sugar transporter protein SLC35A4"
FT                   /id="PRO_0000337753"
FT   TOPO_DOM        1..22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..56
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..91
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..119
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..180
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..211
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..247
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..321
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q96G79"
SQ   SEQUENCE   321 AA;  36033 MW;  81FF9F0495C8FA43 CRC64;
     MYSVNIEPDG SNHSPSRKRL KQILWGLMLV LSVTIYGSHA PLIYLCKVNG EIPFSSSAVV
     LLIELSKFVI SLVFFLIQDW KSLKASVSWH LAAPYAVPAV LYGANNNLVV YIQHFMDPSS
     FQVLSNLKIV STAVLYSLFL RQRLSVRRWL SVFLLLAAGV FYSYGGIQDL EKVSSDTNLY
     VTLPGLLLML AYCLISGLSA VYTEMTLKTQ KIPLNMQNLY LYSFGIIINL TAHLTSSKNS
     DFFDGFSVWV WVIILSQALN GLIMSLVMKL SNNITRLFII SFSMLANGFL SFILFQLQLT
     ALFFLAVVLI GLAVYMYYGM K