S35A5_BOVIN
ID S35A5_BOVIN Reviewed; 425 AA.
AC A6QPI1; Q0V8M4;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Probable UDP-sugar transporter protein SLC35A5;
DE AltName: Full=Solute carrier family 35 member A5;
GN Name=SLC35A5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6QPI1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6QPI1-2; Sequence=VSP_029149, VSP_029150;
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; BT026194; ABG67033.1; -; mRNA.
DR EMBL; BC149334; AAI49335.1; -; mRNA.
DR RefSeq; NP_001069493.2; NM_001076025.2. [A6QPI1-1]
DR RefSeq; XP_005201388.2; XM_005201331.3. [A6QPI1-1]
DR AlphaFoldDB; A6QPI1; -.
DR SMR; A6QPI1; -.
DR STRING; 9913.ENSBTAP00000011977; -.
DR PaxDb; A6QPI1; -.
DR Ensembl; ENSBTAT00000011977; ENSBTAP00000011977; ENSBTAG00000009085. [A6QPI1-1]
DR GeneID; 534488; -.
DR KEGG; bta:534488; -.
DR CTD; 55032; -.
DR VEuPathDB; HostDB:ENSBTAG00000009085; -.
DR eggNOG; KOG2234; Eukaryota.
DR GeneTree; ENSGT00950000182827; -.
DR HOGENOM; CLU_044353_0_0_1; -.
DR InParanoid; A6QPI1; -.
DR OMA; KEGCLDH; -.
DR OrthoDB; 703674at2759; -.
DR TreeFam; TF354304; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000009085; Expressed in occipital lobe and 103 other tissues.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..425
FT /note="Probable UDP-sugar transporter protein SLC35A5"
FT /id="PRO_0000309354"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 398..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 394
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BS91"
FT MOD_RES 416
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BS91"
FT MOD_RES 420
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BS91"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 121..123
FT /note="AMA -> VSK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16305752"
FT /id="VSP_029149"
FT VAR_SEQ 124..425
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16305752"
FT /id="VSP_029150"
SQ SEQUENCE 425 AA; 48142 MW; 23FF75C553F31B18 CRC64;
MESNCGHPML SVSSAMYTFL LGAIFITLSS SRILLVKYSA NEENKYDYLP TTVNVCSELV
KLVFCALVSF WVLKKEDHQN RKLRCGSWKE FFNFMKWSIP AFLYFLDNLI VFYVLSYLQP
AMAVIFSNFS IITTALLFRI VLKRHLNGIQ WASLLILFLS IVALTSGTET SQHSLAGHGF
HHDALFSPSN SCLLFRSECP RKDNCTAKEW TFSEAQWNTT ARVFSHIRLG LGHVLIIVQC
FISSMANIYN EKILKEGNQL TESIFVQNSK LYFFGVLFNG LTLGLQSGNR DQIKNCGIFY
GHNAFSVALI FVTAFQGLSV AFILKFLDNM FHVLMAQVTT VVITTVSVLV FDFRPSLEFF
LEAPSVLLSI LIYNASNPQG VENVPRKERI RDLSGTLWER SSGDGEELER LTKPKSDIES
DEDTF
