S35A5_DANRE
ID S35A5_DANRE Reviewed; 440 AA.
AC Q90X48; Q6PFM7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Probable UDP-sugar transporter protein SLC35A5;
DE AltName: Full=Solute carrier family 35 member A5;
GN Name=slc35a5; ORFNames=si:bZ20I5.1, zgc:66231;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57491.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590146; CAC94895.1; -; Genomic_DNA.
DR EMBL; BC057491; AAH57491.1; ALT_INIT; mRNA.
DR RefSeq; NP_956948.1; NM_200654.1.
DR AlphaFoldDB; Q90X48; -.
DR SMR; Q90X48; -.
DR STRING; 7955.ENSDARP00000000004; -.
DR PaxDb; Q90X48; -.
DR Ensembl; ENSDART00000000004; ENSDARP00000000004; ENSDARG00000000001.
DR GeneID; 368418; -.
DR KEGG; dre:368418; -.
DR CTD; 55032; -.
DR ZFIN; ZDB-GENE-030616-55; slc35a5.
DR eggNOG; KOG2234; Eukaryota.
DR GeneTree; ENSGT00950000182827; -.
DR HOGENOM; CLU_044353_0_0_1; -.
DR InParanoid; Q90X48; -.
DR OMA; KEGCLDH; -.
DR OrthoDB; 703674at2759; -.
DR PhylomeDB; Q90X48; -.
DR TreeFam; TF354304; -.
DR PRO; PR:Q90X48; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000000001; Expressed in mature ovarian follicle and 19 other tissues.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..440
FT /note="Probable UDP-sugar transporter protein SLC35A5"
FT /id="PRO_0000309358"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 15
FT /note="A -> S (in Ref. 2; AAH57491)"
FT /evidence="ECO:0000305"
FT CONFLICT 50
FT /note="S -> G (in Ref. 2; AAH57491)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="L -> F (in Ref. 2; AAH57491)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="F -> L (in Ref. 2; AAH57491)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="N -> G (in Ref. 2; AAH57491)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="M -> I (in Ref. 2; AAH57491)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 440 AA; 49544 MW; 2F848F93D99BBD71 CRC64;
MSFTMARYSS SSSSASSSSC GCCRPCSRIC SRSSAYTLAL GLGFVTLGTS RILLLKFSGN
EENKYDYLPA SVNLMAEAIK LVFCLVMSVR VIIREGRSFK DLGCSSGASF LSYLKWSVPA
FLYFLDNLII FYVIAYLQPA MAVLFSNIVI FTTAFLFRVV LKRRLSWVQW ASLIILFLSI
VSLTTGNGDQ HAMAVHGLHP AHISTPSNSC LKYTHLHQVH QSHNESYWSR ELWDSQLIHK
LNSFGLGYVL LLLQCFISAL ANIYNEKILK EGEQLVESIF IQNSKLYLFG LVFNSLTLLL
HADYRNLTLH CGILYGHNVF SVALGFVTAA LGLSVAFILK FRDNMFHVLT GQITTVVVTA
LSFFLFDFQP SMDFFMQAPV VLLSIFIYHS SKMKDPEYAL QQERLRVING EVFERSRGDG
EELERLTKAN TESESEEESF
