S35B1_DICDI
ID S35B1_DICDI Reviewed; 392 AA.
AC Q54I86; Q54I87;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Solute carrier family 35 member B1;
GN Name=slc35b1; ORFNames=DDB_G0288929;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable sugar transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC for type I membrane proteins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL62987.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAL62988.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAFI02000126; EAL62988.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAFI02000126; EAL62987.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_636492.1; XM_631400.1.
DR RefSeq; XP_636493.1; XM_631401.1.
DR AlphaFoldDB; Q54I86; -.
DR SMR; Q54I86; -.
DR STRING; 44689.DDB0188178; -.
DR PaxDb; Q54I86; -.
DR EnsemblProtists; EAL62987; EAL62987; DDB_G0288927.
DR EnsemblProtists; EAL62988; EAL62988; DDB_G0288929.
DR GeneID; 8626875; -.
DR GeneID; 8626876; -.
DR KEGG; ddi:DDB_G0288927; -.
DR KEGG; ddi:DDB_G0288929; -.
DR dictyBase; DDB_G0288929; -.
DR eggNOG; KOG1580; Eukaryota.
DR InParanoid; Q54I86; -.
DR PhylomeDB; Q54I86; -.
DR PRO; PR:Q54I86; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0072334; P:UDP-galactose transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..392
FT /note="Solute carrier family 35 member B1"
FT /id="PRO_0000330911"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 389..392
FT /note="Di-lysine motif"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 44614 MW; 860EBC52F79A9F4D CRC64;
MSLTKKIKNE KSLKQEKQTD QLKSNLRNNN NNINNKSKPK DQNLNTLHYI KTHLKEELFF
IFCVGGIYIF YLLYGLVQEQ LNVTKFGTEK KVFGFTAFLL ALQCFFNMVS AWLVSLVNKE
QKDNTPFMKY GFVSMLLVIS TFLSNQSIRY ISYPTQVLAK SCKPIPVIFM GLLLFKKKYP
FLKYIVVIVI SLGISLFMLP KATSKKNIQF EGHDHLFGNF ILFVSLMMDG VMGPFQDNLV
RQYKPSATSM MLNTNIWNLG LFSIMAFARG EVSQAIDFIL EYPEVIKLIL AFCITSAIGQ
QFIFLTTNKF GSLNCSTITT TRKFFSILVS IFYFGHSLDN LQWAAICMVF GGLILDLYIS
YSNKKKGVVL SPIAAPVKHP TATTPLENKK SL
