S35B1_RAT
ID S35B1_RAT Reviewed; 322 AA.
AC Q6V7K3; P70639;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Solute carrier family 35 member B1;
DE AltName: Full=ATP/ADP exchanger ER {ECO:0000250|UniProtKB:P78383};
DE Short=AXER {ECO:0000250|UniProtKB:P78383};
DE AltName: Full=Endoplasmic reticulum ATP/ADP translocase {ECO:0000250|UniProtKB:P78383};
DE AltName: Full=UDP-galactose transporter-related protein 1 {ECO:0000250|UniProtKB:P78383};
DE Short=UGTrel1 {ECO:0000250|UniProtKB:P78383};
GN Name=Slc35b1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9010752; DOI=10.1093/oxfordjournals.jbchem.a021523;
RA Ishida N., Miura N., Yoshioka S., Kawakita M.;
RT "Molecular cloning and characterization of a novel isoform of the human
RT UDP-galactose transporter, and of related complementary DNAs belonging to
RT the nucleotide-sugar transporter gene family.";
RL J. Biochem. 120:1074-1078(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RA Rydlova H., Perez-Marquez J.;
RT "Rattus norvegicus galactose transporter cDNA.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: ATP:ADP antiporter that catalyzes the exchange of ATP and ADP
CC across the endoplasmic reticulum (ER) membrane. Imports ATP from the
CC cytosol to the ER lumen and exports ADP in the opposite direction (By
CC similarity). Regulates ER energy metabolism and protein biogenesis.
CC Appears to be part of a calcium-dependent ER to cytosol low energy
CC response axis, where calcium efflux from ER to the cytosol triggers ATP
CC import into the ER lumen to maintain sufficient ATP supply. Provides
CC ATP to ER chaperone HSPA5 that drives protein folding and trafficking
CC in the ER (By similarity). Can transport UTP or UDP in exchange for
CC ATP, but the physiological relevance of this process remains to be
CC established (By similarity). {ECO:0000250|UniProtKB:P78383}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP(in) + ATP(out) = ADP(out) + ATP(in); Xref=Rhea:RHEA:34999,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000250|UniProtKB:P78383};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:35001;
CC Evidence={ECO:0000250|UniProtKB:P78383};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P78383}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC for type I membrane proteins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
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DR EMBL; D87991; BAA13527.1; -; mRNA.
DR EMBL; AY349135; AAQ79836.1; -; mRNA.
DR EMBL; BC085347; AAH85347.1; -; mRNA.
DR RefSeq; NP_954512.1; NM_199081.1.
DR AlphaFoldDB; Q6V7K3; -.
DR SMR; Q6V7K3; -.
DR STRING; 10116.ENSRNOP00000006179; -.
DR PaxDb; Q6V7K3; -.
DR PRIDE; Q6V7K3; -.
DR GeneID; 287642; -.
DR KEGG; rno:287642; -.
DR UCSC; RGD:727783; rat.
DR CTD; 10237; -.
DR RGD; 727783; Slc35b1.
DR eggNOG; KOG1580; Eukaryota.
DR HOGENOM; CLU_036019_1_0_1; -.
DR InParanoid; Q6V7K3; -.
DR OrthoDB; 1220063at2759; -.
DR PhylomeDB; Q6V7K3; -.
DR TreeFam; TF105967; -.
DR PRO; PR:Q6V7K3; -.
DR Proteomes; UP000002494; Unplaced.
DR Genevisible; Q6V7K3; RN.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:RGD.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0005471; F:ATP:ADP antiporter activity; ISO:RGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0072334; P:UDP-galactose transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 2: Evidence at transcript level;
KW Antiport; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..322
FT /note="Solute carrier family 35 member B1"
FT /id="PRO_0000213368"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 318..322
FT /note="Di-lysine motif"
SQ SEQUENCE 322 AA; 35817 MW; 0541F88DF0ABE06B CRC64;
MAASRSLVPD RLRLPLCFLG VFVCYFYYGI LQEKITRGKY GEGPKQETFT FALTLVFIQC
VINAMFAKIL IQFFDTARVD RTRTWLYAAC SVSYVGAMVS SNSALQFVNY PTQVLGKSCK
PIPVMLLGVT LLKKKYPLAK YLCVLLIVAG VALFMYKPKK VVGIEEHTVG FGELLLLLSL
TLDGLTGVSQ DHMRAHYQTG SNHMMLNINL WSTVLLGAGI LFTGELWEFL SFAERYPTII
YNILLFGLTS ALGQSFIFMT VVYFGPLTCS IITTTRKFFT ILASVILFAN PISSMQWVGT
VLVFLGLGLD AKFGKGTKKT SH
