ID   S35B1_XENLA             Reviewed;         320 AA.
AC   Q6GQ70; Q7ZYU1; Q8JFZ0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Solute carrier family 35 member B1;
DE   AltName: Full=Endoplasmic reticulum nucleotide sugar transporter 1;
GN   Name=slc35b1; Synonyms=ernst1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND GENE FAMILY.
RX   PubMed=12770764; DOI=10.1016/s0300-9084(03)00046-4;
RA   Martinez-Duncker I., Mollicone R., Codogno P., Oriol R.;
RT   "The nucleotide-sugar transporter family: a phylogenetic approach.";
RL   Biochimie 85:245-260(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte, and Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable sugar transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC       for type I membrane proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH41278.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ506039; CAD44563.1; -; mRNA.
DR   EMBL; BC041278; AAH41278.1; ALT_INIT; mRNA.
DR   EMBL; BC072878; AAH72878.1; -; mRNA.
DR   EMBL; BC077624; AAH77624.1; -; mRNA.
DR   RefSeq; NP_001082304.1; NM_001088835.1.
DR   RefSeq; NP_001082421.1; NM_001088952.1.
DR   AlphaFoldDB; Q6GQ70; -.
DR   SMR; Q6GQ70; -.
DR   DNASU; 398458; -.
DR   GeneID; 398458; -.
DR   KEGG; xla:398458; -.
DR   CTD; 398458; -.
DR   Xenbase; XB-GENE-972783; slc35b1.L.
DR   OrthoDB; 1220063at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 398458; Expressed in liver and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..320
FT                   /note="Solute carrier family 35 member B1"
FT                   /id="PRO_0000213371"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           316..320
FT                   /note="Di-lysine motif"
FT   CONFLICT        190
FT                   /note="Y -> H (in Ref. 1; CAD44563)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        205
FT                   /note="S -> N (in Ref. 1; CAD44563)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        208
FT                   /note="L -> M (in Ref. 1; CAD44563)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        220
FT                   /note="L -> F (in Ref. 1; CAD44563)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        226
FT                   /note="D -> E (in Ref. 1; CAD44563)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        242
FT                   /note="V -> L (in Ref. 1; CAD44563)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        299
FT                   /note="L -> I (in Ref. 1; CAD44563)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   320 AA;  35352 MW;  BBF77FFD3259601D CRC64;
     MSSAPASGGL RLLVCFLGVF VCYFYYGILQ ETITRRTYGE GEKQEKFRFA LSLVFVQCIV
     NALFAKLLIQ CFDSGKTDRT QSWLYSACSL SYLGAMVSSN SALQFVNYPT QVLGKSCKPI
     PVMLLGVTLL RKKYPLTKYL CVLLIVFGVA LFMYKPKTGS GDGDHTVGYG ELLLLLSLTL
     DGLTGVSQDY MRAHFQTGSN HMMLSINLWS SLFLGAGIVL TGELWDFLSF TERYPSIVYN
     IVLFSLTSAL GQTFIFMTVV YFGPLTCSII TTTRKFFTIL ASVILFSNPI SSIQWVGTLL
     VFLGLGLDAT YGKGSKKPSH