S35B2_CAEEL
ID S35B2_CAEEL Reviewed; 425 AA.
AC Q8MXJ9; O16377; Q59DN2; Q59DN3; Q59DN4;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 4.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Adenosine 3'-phospho 5'-phosphosulfate transporter 1;
DE AltName: Full=PAPS transporter 1;
GN Name=pst-1; ORFNames=M03F8.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Mediates the transport of adenosine 3'-phospho 5'-
CC phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal
CC sulfuryl donor for sulfation events that take place in the Golgi (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=Q8MXJ9-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q8MXJ9-2; Sequence=VSP_014086;
CC Name=c;
CC IsoId=Q8MXJ9-3; Sequence=VSP_014086, VSP_014403;
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
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DR EMBL; FO080495; CCD64140.1; -; Genomic_DNA.
DR EMBL; FO080495; CCD64141.1; -; Genomic_DNA.
DR EMBL; FO080495; CCD64142.1; -; Genomic_DNA.
DR PIR; T31809; T31809.
DR RefSeq; NP_001024060.1; NM_001028889.2. [Q8MXJ9-3]
DR RefSeq; NP_741545.2; NM_171463.4. [Q8MXJ9-1]
DR RefSeq; NP_741546.3; NM_171464.3. [Q8MXJ9-2]
DR AlphaFoldDB; Q8MXJ9; -.
DR SMR; Q8MXJ9; -.
DR STRING; 6239.M03F8.2b; -.
DR EPD; Q8MXJ9; -.
DR PaxDb; Q8MXJ9; -.
DR PeptideAtlas; Q8MXJ9; -.
DR PRIDE; Q8MXJ9; -.
DR EnsemblMetazoa; M03F8.2a.1; M03F8.2a.1; WBGene00004206. [Q8MXJ9-1]
DR EnsemblMetazoa; M03F8.2b.1; M03F8.2b.1; WBGene00004206. [Q8MXJ9-2]
DR EnsemblMetazoa; M03F8.2c.1; M03F8.2c.1; WBGene00004206. [Q8MXJ9-3]
DR GeneID; 178980; -.
DR UCSC; M03F8.2a; c. elegans. [Q8MXJ9-1]
DR CTD; 178980; -.
DR WormBase; M03F8.2a; CE38399; WBGene00004206; pst-1. [Q8MXJ9-1]
DR WormBase; M03F8.2b; CE38400; WBGene00004206; pst-1. [Q8MXJ9-2]
DR WormBase; M03F8.2c; CE38401; WBGene00004206; pst-1. [Q8MXJ9-3]
DR eggNOG; KOG1581; Eukaryota.
DR GeneTree; ENSGT00940000157927; -.
DR InParanoid; Q8MXJ9; -.
DR OMA; CGAIGQV; -.
DR OrthoDB; 820879at2759; -.
DR PhylomeDB; Q8MXJ9; -.
DR Reactome; R-CEL-174362; Transport and synthesis of PAPS.
DR Reactome; R-CEL-727802; Transport of nucleotide sugars.
DR PRO; PR:Q8MXJ9; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00004206; Expressed in adult organism and 4 other tissues.
DR ExpressionAtlas; Q8MXJ9; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IDA:WormBase.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IDA:WormBase.
DR GO; GO:0046964; F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; IDA:WormBase.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046963; P:3'-phosphoadenosine 5'-phosphosulfate transport; IDA:WormBase.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..425
FT /note="Adenosine 3'-phospho 5'-phosphosulfate transporter
FT 1"
FT /id="PRO_0000213377"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..11
FT /note="MDRSIMPIDSP -> MDPLSWGRGWYAIQTISGSVIQYLKE (in
FT isoform b and isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_014086"
FT VAR_SEQ 377..425
FT /note="MLSIVLSTIMYGHELTFLAAIGFMIVFAAIFVDIHKKYSDKSRGPQRSW ->
FT RWLHLHHLNRFVSNFYQ (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_014403"
SQ SEQUENCE 425 AA; 48125 MW; F350E347F2DE36C4 CRC64;
MDRSIMPIDS PARDKPPDEL VWPLRLFLIL LGYSTVATPA AILIYYVRRN RHAFETPYLS
IRLLLRSFAV GNPEYQLIPT GEKQARKEND SIPQTRAQCI NVIILLLFFF SGIQVTLVAM
GVLQERIITR GYRRSDQLEV EDKFGETQFL IFCNRIVALV LSLMILAKDW TKQPPHVPPL
YVHSYTSFSN TISSWCQYEA LKYVSFPTQT ICKASKVVVT MLMGRLVRGQ RYSWFEYGCG
CTIAFGASLF LLSSSSKGAG STITYTSFSG MILMAGYLLF DAFTLNWQKA LFDTKPKVSK
YQMMFGVNFF SAILCAVSLI EQGTLWSSIK FGAEHVDFSR DVFLLSLSGA IGQIFIYSTI
ERFGPIVFAV IMTIRQMLSI VLSTIMYGHE LTFLAAIGFM IVFAAIFVDI HKKYSDKSRG
PQRSW
