ID   S35B2_DICDI             Reviewed;         359 AA.
AC   Q55DM5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Adenosine 3'-phospho 5'-phosphosulfate transporter 1;
DE   AltName: Full=PAPS transporter 1;
DE   AltName: Full=Solute carrier family 35 member B2;
GN   Name=slc35b2; Synonyms=papst1; ORFNames=DDB_G0269602;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Mediates the transport of adenosine 3'-phospho 5'-
CC       phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal
CC       sulfuryl donor for sulfation events that take place in the Golgi (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72151.1; -; Genomic_DNA.
DR   RefSeq; XP_646106.1; XM_641014.1.
DR   AlphaFoldDB; Q55DM5; -.
DR   SMR; Q55DM5; -.
DR   EnsemblProtists; EAL72151; EAL72151; DDB_G0269602.
DR   GeneID; 8617056; -.
DR   KEGG; ddi:DDB_G0269602; -.
DR   dictyBase; DDB_G0269602; slc35b2.
DR   InParanoid; Q55DM5; -.
DR   OMA; IMTTRQM; -.
DR   PhylomeDB; Q55DM5; -.
DR   Reactome; R-DDI-174362; Transport and synthesis of PAPS.
DR   Reactome; R-DDI-727802; Transport of nucleotide sugars.
DR   PRO; PR:Q55DM5; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0046964; F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..359
FT                   /note="Adenosine 3'-phospho 5'-phosphosulfate transporter
FT                   1"
FT                   /id="PRO_0000330912"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          332..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   359 AA;  39555 MW;  96004356EC8D70CD CRC64;
     MGSGIEVNDS STTNSNNNEK VQLSYNMKLA LATGGIMGSF LLYGILQERL MVVPYKNADG
     SEEYFTDSTF LVLSNRVFAA LMAIVIVLKR GESLKNVAPL HKYVGVALSN FCATWCQYEA
     LKYVNFPTQT LGKCGKMLPV MLVGTFISGK KYGLKDYSIA LTITTGCMIF FLTGKISNNE
     SSNTSYGIIL MALYMFFDSF TSTFQEKMFK GYTMSTYDQM IYVNGCSSII SVFILILNGR
     LFPAIEFIST HNGVFFDSTM LSASAGLGQM VIYYTIKEFG ALVFSTIMVT RQMVSIILST
     LIYLHPLSNT QWIGALLVFG TLYYKSIEDS KKKHGGHSHG GSNAATTTTP SNNSNNTEK